ZN708_HUMAN
ID ZN708_HUMAN Reviewed; 563 AA.
AC P17019; Q6ZMR0;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 23-FEB-2022, sequence version 6.
DT 03-AUG-2022, entry version 186.
DE RecName: Full=Zinc finger protein 708 {ECO:0000305};
DE AltName: Full=Zinc finger protein 15;
DE AltName: Full=Zinc finger protein 15-like 1;
DE AltName: Full=Zinc finger protein KOX8;
GN Name=ZNF708 {ECO:0000312|HGNC:HGNC:12945}; Synonyms=KOX8, ZNF15, ZNF15L1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS VAL-71 AND GLN-130.
RC TISSUE=Cerebellum, and Hippocampus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 476-531.
RC TISSUE=Lymphoid tissue;
RX PubMed=2288909;
RA Thiesen H.-J.;
RT "Multiple genes encoding zinc finger domains are expressed in human T
RT cells.";
RL New Biol. 2:363-374(1990).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-544, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK131527; BAD18665.1; -; mRNA.
DR EMBL; AC022432; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; X52339; CAA36565.1; -; mRNA.
DR CCDS; CCDS32980.1; -.
DR PIR; I37976; I37976.
DR RefSeq; NP_001284489.1; NM_001297560.1.
DR RefSeq; NP_001284490.1; NM_001297561.1.
DR AlphaFoldDB; P17019; -.
DR BioGRID; 113394; 19.
DR IntAct; P17019; 2.
DR STRING; 9606.ENSP00000349401; -.
DR iPTMnet; P17019; -.
DR PhosphoSitePlus; P17019; -.
DR BioMuta; ZNF708; -.
DR DMDM; 527504092; -.
DR EPD; P17019; -.
DR jPOST; P17019; -.
DR MassIVE; P17019; -.
DR MaxQB; P17019; -.
DR PaxDb; P17019; -.
DR PeptideAtlas; P17019; -.
DR PRIDE; P17019; -.
DR ProteomicsDB; 53415; -.
DR Antibodypedia; 28681; 93 antibodies from 14 providers.
DR DNASU; 7562; -.
DR Ensembl; ENST00000356929.3; ENSP00000349401.2; ENSG00000182141.10.
DR GeneID; 7562; -.
DR KEGG; hsa:7562; -.
DR MANE-Select; ENST00000356929.3; ENSP00000349401.2; NM_021269.3; NP_067092.2.
DR UCSC; uc002npq.2; human.
DR CTD; 7562; -.
DR GeneCards; ZNF708; -.
DR HGNC; HGNC:12945; ZNF708.
DR HPA; ENSG00000182141; Tissue enhanced (brain).
DR neXtProt; NX_P17019; -.
DR OpenTargets; ENSG00000182141; -.
DR VEuPathDB; HostDB:ENSG00000182141; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000153236; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; P17019; -.
DR OrthoDB; 1318335at2759; -.
DR TreeFam; TF342117; -.
DR PathwayCommons; P17019; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; P17019; -.
DR BioGRID-ORCS; 7562; 6 hits in 1027 CRISPR screens.
DR ChiTaRS; ZNF708; human.
DR GenomeRNAi; 7562; -.
DR Pharos; P17019; Tdark.
DR PRO; PR:P17019; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; P17019; protein.
DR Bgee; ENSG00000182141; Expressed in cortical plate and 131 other tissues.
DR ExpressionAtlas; P17019; baseline and differential.
DR Genevisible; P17019; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 13.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 15.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..563
FT /note="Zinc finger protein 708"
FT /id="PRO_0000047706"
FT DOMAIN 4..75
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 140..162
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 168..190
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 196..218
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 224..246
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 252..274
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 280..302
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 308..330
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 336..358
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 364..386
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 392..414
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 420..442
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 448..470
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 476..498
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 504..526
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 532..554
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT MOD_RES 544
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21406692"
FT VARIANT 71
FT /note="A -> V (in dbSNP:rs547516)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_054795"
FT VARIANT 113
FT /note="K -> E (in dbSNP:rs1781873)"
FT /id="VAR_054796"
FT VARIANT 122
FT /note="K -> T (in dbSNP:rs1781872)"
FT /id="VAR_054797"
FT VARIANT 130
FT /note="R -> Q (in dbSNP:rs504280)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_054798"
SQ SEQUENCE 563 AA; 64779 MW; 633BFC91E6DC40CD CRC64;
MGPLTFMDVA IEFSLEEWQC LDTAQQNLYR NVMLENYRNL VFLGIAVSNL DLITCLEQGK
EPWNMKRHEM AAKPPAMCSH FAKDLRPEQY IKNSFQQVIL RRYGKCGYQK GCKSVDEHKL
HKGGHKGLNR CVTTTQSKIV QCDKYVKVFH KYSNAKRHKI RHTGKNPFKC KECGKSFCML
SQLTQHEIIH TGEKPYKCEE CGKAFKKSSN LTNHKIIHTG EKPYKCEECG KAFNQSSTLT
RHKIIHTGEK LYKCEECGKA FNRSSNLTKH KIVHTGEKPY KCEECGKAFK QSSNLTNHKK
IHTGEKPYKC GECGKAFTLS SHLTTHKRIH TGEKPYKCEE CGKAFSVFST LTKHKIIHTE
EKPYKCEECG KAFNRSSHLT NHKVIHTGEK PYKCEECGKA FTKSSTLTYH KVIHTGKKPY
KCEECGKAFS IFSILTKHKV IHTEDKPYKC EECGKTFNYS SNFTNHKKIH TGEKPYKCEE
CGKSFILSSH LTTHKIIHTG EKPYKCKECG KAFNQSSTLM KHKIIHTGEK PYKCEECGKA
FNQSPNLTKH KRIHTKEKPY KCK
