ZN709_HUMAN
ID ZN709_HUMAN Reviewed; 641 AA.
AC Q8N972; A8K4E6;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Zinc finger protein 709;
GN Name=ZNF709;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK095600; BAC04584.1; -; mRNA.
DR EMBL; AK290911; BAF83600.1; -; mRNA.
DR EMBL; CH471106; EAW84275.1; -; Genomic_DNA.
DR EMBL; BC136746; AAI36747.1; -; mRNA.
DR EMBL; BC136751; AAI36752.1; -; mRNA.
DR CCDS; CCDS42504.1; -.
DR RefSeq; NP_689814.1; NM_152601.3.
DR AlphaFoldDB; Q8N972; -.
DR SMR; Q8N972; -.
DR BioGRID; 127845; 11.
DR IntAct; Q8N972; 3.
DR STRING; 9606.ENSP00000380840; -.
DR iPTMnet; Q8N972; -.
DR PhosphoSitePlus; Q8N972; -.
DR BioMuta; ZNF709; -.
DR DMDM; 74760022; -.
DR EPD; Q8N972; -.
DR jPOST; Q8N972; -.
DR MassIVE; Q8N972; -.
DR MaxQB; Q8N972; -.
DR PaxDb; Q8N972; -.
DR PeptideAtlas; Q8N972; -.
DR PRIDE; Q8N972; -.
DR ProteomicsDB; 72497; -.
DR Antibodypedia; 34984; 51 antibodies from 15 providers.
DR DNASU; 163051; -.
DR Ensembl; ENST00000397732.8; ENSP00000380840.3; ENSG00000242852.7.
DR GeneID; 163051; -.
DR KEGG; hsa:163051; -.
DR MANE-Select; ENST00000397732.8; ENSP00000380840.3; NM_152601.4; NP_689814.1.
DR UCSC; uc002mtv.5; human.
DR CTD; 163051; -.
DR GeneCards; ZNF709; -.
DR HGNC; HGNC:20629; ZNF709.
DR HPA; ENSG00000242852; Tissue enriched (testis).
DR neXtProt; NX_Q8N972; -.
DR PharmGKB; PA142670469; -.
DR VEuPathDB; HostDB:ENSG00000242852; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00950000182755; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q8N972; -.
DR OMA; WEEKNTE; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8N972; -.
DR TreeFam; TF343410; -.
DR PathwayCommons; Q8N972; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q8N972; -.
DR BioGRID-ORCS; 163051; 11 hits in 1017 CRISPR screens.
DR ChiTaRS; ZNF709; human.
DR GenomeRNAi; 163051; -.
DR Pharos; Q8N972; Tdark.
DR PRO; PR:Q8N972; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8N972; protein.
DR Bgee; ENSG00000242852; Expressed in right testis and 112 other tissues.
DR ExpressionAtlas; Q8N972; baseline and differential.
DR Genevisible; Q8N972; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 9.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 19.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 11.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 19.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 19.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..641
FT /note="Zinc finger protein 709"
FT /id="PRO_0000230312"
FT DOMAIN 4..75
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 102..124
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 140..162
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 168..190
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 196..218
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 224..246
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 252..274
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 280..302
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 308..330
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 336..358
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 364..386
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 392..414
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 420..442
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 448..470
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 476..498
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 504..526
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 532..554
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 560..582
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 588..610
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 616..638
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ SEQUENCE 641 AA; 74652 MW; 51BDA6D9D6DE0B41 CRC64;
MDSVVFEDVA VNFTQEEWAL LGPSQKKLYR DVMQETFVNL ASIGENWEEK NIEDHKNQGR
KLRSHMVERL CERKEGSQFG ETISQTPNPK PNKKTFTRVK PYECSVCGKD YMCHSSLNRH
MRSHTEHRSY EYHKYGEKSY ECKECGKRFS FRSSFRIHER THTGEKPYKC KQCGKAFSWP
SSFQIHERTH TGEKPYECKE CGKAFIYHTT FRGHMRMHTG EKPYKCKECG KTFSHPSSFR
NHERTHSGEK PYECKQCGKA FRYYQTFQIH ERTHTGEKPY QCKQCGKALS CPTSFRSHER
IHTGEKPYKC KKCGKAFSFP SSFRKHERIH TGEKPYDCKE CGKAFISLPS YRRHMIMHTG
NGPYKCKECG KAFDCPSSFQ IHERTHTGEK PYECKQCGKA FSCSSSFRMH ERTHTGEKPH
ECKQCGKAFS CSSSVRIHER THTGEKPYEC KQCGKAFSCS SSFRMHERIH TGEKPYECKQ
CGKAFSFSSS FRMHERTHTG EKPYECKQCG KAFSCSSSFR MHERTHTGEK PYECKQCGKA
FSCSSSIRIH ERTHTGEKPY ECKQCGKAFS CSSSVRMHER THTGVKPYEC KQCDKAFSCS
RSFRIHERTH TGEKPYACQQ CGKAFKCSRS FRIHERVHSG E
