ZN710_MOUSE
ID ZN710_MOUSE Reviewed; 666 AA.
AC Q3U288; Q3U341; Q3U396; Q6P9R3; Q8BJH0; Q8BTL6; Q8BZ48;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Zinc finger protein 710;
GN Name=Znf710; Synonyms=Zfp710;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC STRAIN=C57BL/6J, and NOD; TISSUE=Bone, Dendritic cell, and Spinal ganglion;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q3U288-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3U288-2; Sequence=VSP_018152;
CC Name=3;
CC IsoId=Q3U288-3; Sequence=VSP_026943;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH58640.3; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAH60641.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC40892.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK036711; BAC29546.1; -; mRNA.
DR EMBL; AK083979; BAC39083.1; -; mRNA.
DR EMBL; AK089457; BAC40892.1; ALT_INIT; mRNA.
DR EMBL; AK154871; BAE32892.1; -; mRNA.
DR EMBL; AK154953; BAE32948.1; -; mRNA.
DR EMBL; AK155416; BAE33254.1; -; mRNA.
DR EMBL; BC058640; AAH58640.3; ALT_INIT; mRNA.
DR EMBL; BC060641; AAH60641.1; ALT_INIT; mRNA.
DR CCDS; CCDS52279.1; -. [Q3U288-3]
DR CCDS; CCDS52280.1; -. [Q3U288-1]
DR RefSeq; NP_001139471.1; NM_001145999.1. [Q3U288-1]
DR RefSeq; NP_001139472.1; NM_001146000.1. [Q3U288-3]
DR RefSeq; NP_780642.3; NM_175433.5. [Q3U288-1]
DR RefSeq; XP_006540805.1; XM_006540742.3. [Q3U288-1]
DR RefSeq; XP_006540806.1; XM_006540743.3. [Q3U288-1]
DR RefSeq; XP_006540807.1; XM_006540744.3. [Q3U288-1]
DR AlphaFoldDB; Q3U288; -.
DR SMR; Q3U288; -.
DR BioGRID; 229060; 33.
DR STRING; 10090.ENSMUSP00000050577; -.
DR iPTMnet; Q3U288; -.
DR PhosphoSitePlus; Q3U288; -.
DR MaxQB; Q3U288; -.
DR PaxDb; Q3U288; -.
DR PeptideAtlas; Q3U288; -.
DR PRIDE; Q3U288; -.
DR ProteomicsDB; 275032; -. [Q3U288-1]
DR ProteomicsDB; 275033; -. [Q3U288-2]
DR ProteomicsDB; 275034; -. [Q3U288-3]
DR DNASU; 209225; -.
DR Ensembl; ENSMUST00000049680; ENSMUSP00000050577; ENSMUSG00000048897. [Q3U288-1]
DR Ensembl; ENSMUST00000164056; ENSMUSP00000132361; ENSMUSG00000048897. [Q3U288-1]
DR Ensembl; ENSMUST00000166250; ENSMUSP00000129357; ENSMUSG00000048897. [Q3U288-3]
DR Ensembl; ENSMUST00000206039; ENSMUSP00000146148; ENSMUSG00000048897. [Q3U288-2]
DR GeneID; 209225; -.
DR KEGG; mmu:209225; -.
DR UCSC; uc009hzi.2; mouse. [Q3U288-3]
DR UCSC; uc009hzj.2; mouse. [Q3U288-1]
DR UCSC; uc009hzk.2; mouse. [Q3U288-2]
DR CTD; 209225; -.
DR MGI; MGI:1921747; Zfp710.
DR VEuPathDB; HostDB:ENSMUSG00000048897; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000155498; -.
DR HOGENOM; CLU_002678_54_1_1; -.
DR InParanoid; Q3U288; -.
DR OMA; MEDYEEN; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q3U288; -.
DR TreeFam; TF331510; -.
DR Reactome; R-MMU-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 209225; 5 hits in 75 CRISPR screens.
DR ChiTaRS; Zfp710; mouse.
DR PRO; PR:Q3U288; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q3U288; protein.
DR Bgee; ENSMUSG00000048897; Expressed in granulocyte and 204 other tissues.
DR ExpressionAtlas; Q3U288; baseline and differential.
DR Genevisible; Q3U288; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 10.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Isopeptide bond; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1..666
FT /note="Zinc finger protein 710"
FT /id="PRO_0000233709"
FT ZN_FING 297..319
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 325..347
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 353..375
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 381..403
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 409..431
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 437..459
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 465..487
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 493..515
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 521..543
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 549..571
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 577..600
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 113..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 110
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q8N1W2"
FT CROSSLNK 113
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q8N1W2"
FT CROSSLNK 379
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q8N1W2"
FT VAR_SEQ 611..666
FT /note="DPMMELAGPDPSELDNHQEMEDFEENAYTYSSVDSSAEASTLTEQAMKEMAY
FT YNVL -> GGWAVRSGQSRIDSSMAHSGVSSPIRGVGGLAKAETSMRWAQVWREGEPGE
FT PLWQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_018152"
FT VAR_SEQ 611..666
FT /note="DPMMELAGPDPSELDNHQEMEDFEENAYTYSSVDSSAEASTLTEQAMKEMAY
FT YNVL -> GMLSTAARAAGCSYASSSSTQSAILCGVQGQPETP (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_026943"
FT CONFLICT 5
FT /note="M -> L (in Ref. 1; BAE32948)"
FT /evidence="ECO:0000305"
FT CONFLICT 259
FT /note="D -> E (in Ref. 1; BAE32948)"
FT /evidence="ECO:0000305"
FT CONFLICT 409
FT /note="H -> R (in Ref. 1; BAC39083)"
FT /evidence="ECO:0000305"
FT CONFLICT 620
FT /note="D -> G (in Ref. 1; BAE32948)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 666 AA; 75052 MW; 726110C48EAD2054 CRC64;
MEGFMDSGTQ TDAVVVLSLA QAAVLGLVSE NELFGATISA EAFYPDLGPE LTGTAMGEPG
PPGPDIYQLA CNGRALEEPP EEEVLEVEAA FEKHTRRKTR PPVRLVPKVK FEKAEEEEEQ
EVYEVSVPGD DKDPGPAEAP AEVASSGCEA LVQSSAVKMI DLSAFSRKPR TLRHLPRTPR
PELDMAPFDP PFPDPARDGF PEPSMALPGP ETLPTECSFE PPHLAPLSNP EPPNMTSTTE
LVKPEQGFVW QESSEFEADT AGSTVERHKK AQLDRLDINV QIDDSYLVEA GDRQKRWQCR
MCEKSYTSKY NLVTHILGHN GIKPHSCPHC SKLFKQPSHL QTHLLTHQGT RPHKCQVCHK
AFTQTSHLKR HMLLHSEVKP YSCHFCGRGF AYPSELKAHE VKHESGRCHV CVECGLDFST
LTQLKRHLAS HQGPTLYQCL ECDKSFHYRS QLQNHMLKHQ NVRPFVCTEC GMEFSQIHHL
KQHSLTHKGV KEFKCEVCGR EFTLQANMKR HMLIHTSVRP YQCHICFKTF VQKQTLKTHM
IVHSPVKPFK CKVCGKSFNR MYNLLGHMHL HAGSKPFKCP YCSSKFNLKG NLSRHMKVKH
GVMDISLDSQ DPMMELAGPD PSELDNHQEM EDFEENAYTY SSVDSSAEAS TLTEQAMKEM
AYYNVL
