ZN723_HUMAN
ID ZN723_HUMAN Reviewed; 513 AA.
AC P0DPD5;
DT 31-JAN-2018, integrated into UniProtKB/Swiss-Prot.
DT 31-JAN-2018, sequence version 1.
DT 03-AUG-2022, entry version 24.
DE RecName: Full=Zinc finger protein 723 {ECO:0000305};
GN Name=ZNF723 {ECO:0000312|HGNC:HGNC:32286};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AC008626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC022145; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS86735.1; -.
DR AlphaFoldDB; P0DPD5; -.
DR SMR; P0DPD5; -.
DR iPTMnet; P0DPD5; -.
DR PhosphoSitePlus; P0DPD5; -.
DR jPOST; P0DPD5; -.
DR MassIVE; P0DPD5; -.
DR PeptideAtlas; P0DPD5; -.
DR PRIDE; P0DPD5; -.
DR Ensembl; ENST00000600766.3; ENSP00000494306.1; ENSG00000268696.3.
DR MANE-Select; ENST00000600766.3; ENSP00000494306.1; NM_001349726.2; NP_001336655.1.
DR GeneCards; ZNF723; -.
DR HGNC; HGNC:32286; ZNF723.
DR HPA; ENSG00000268696; Tissue enriched (testis).
DR neXtProt; NX_P0DPD5; -.
DR OpenTargets; ENSG00000268696; -.
DR VEuPathDB; HostDB:ENSG00000268696; -.
DR GeneTree; ENSGT01050000244908; -.
DR OMA; AFKIRTH; -.
DR Pharos; P0DPD5; Tdark.
DR PRO; PR:P0DPD5; -.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000268696; Expressed in testis and 16 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 11.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..513
FT /note="Zinc finger protein 723"
FT /id="PRO_0000442922"
FT DOMAIN 4..75
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 173..195
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 201..223
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 229..251
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 257..279
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 285..307
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 313..335
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 341..363
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 369..391
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 397..419
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 425..447
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 453..475
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 481..503
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ SEQUENCE 513 AA; 59152 MW; 3C291F2FB42CFDE8 CRC64;
MGPLTFTDVA IKFSLEEWQF LDTAQQNLYR DVMLENYRNL VFLGVGVSKP DLITCLEQGK
EPWNMKRHKM VAKPPVVCSH FAQDLWPEQG IKDSFQKVIL RSYGKYGHDN LQLRKGCESV
DECKMHKGGY DELKQCLTTT PSKIFQCDKY VKVFHKFSSS NSQKIRHTGN NSFKCKECGK
SFCMLSHLTK HERNHTRVNC YKCEECGKAF SVPSKLNNHK RIHTGEKPYK CEECGKAFNV
SSSLNNHKRI HTGEKPYKCE ECGKTFNMFS SLNNHKRIHT GEKPYKCKEC GKAFNVFSSL
NNHKRIHTGE KPYKCEECGK AFNQPSHLAT HKRIHTGEKL YKCEECGKAF SQSSHITTHK
RIHTGEKPYK CEECGKAFKV SVHLTTHKRI HTGEKPYKCE ECGKAFNQSS ALTTHKIIHT
GERPYKCKQC GKGFSQSSTL TKHKIIHTKE KPYKCEECGK AFNQYSTLNK HKIIHAREKP
YKCEECGKAF NKSSILNRHK IIHTKEKSQT LKM
