ZN724_HUMAN
ID ZN724_HUMAN Reviewed; 619 AA.
AC A8MTY0; B4DVU0;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2009, sequence version 3.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Zinc finger protein 724 {ECO:0000305};
GN Name=ZNF724 {ECO:0000312|HGNC:HGNC:32460};
GN Synonyms=ZNF724P {ECO:0000312|HGNC:HGNC:32460};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK301230; BAG62802.1; -; mRNA.
DR EMBL; AC092329; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS86737.1; -.
DR AlphaFoldDB; A8MTY0; -.
DR SMR; A8MTY0; -.
DR IntAct; A8MTY0; 19.
DR STRING; 9606.ENSP00000413411; -.
DR iPTMnet; A8MTY0; -.
DR PhosphoSitePlus; A8MTY0; -.
DR BioMuta; ZNF724; -.
DR EPD; A8MTY0; -.
DR jPOST; A8MTY0; -.
DR MassIVE; A8MTY0; -.
DR MaxQB; A8MTY0; -.
DR PaxDb; A8MTY0; -.
DR PeptideAtlas; A8MTY0; -.
DR PRIDE; A8MTY0; -.
DR ProteomicsDB; 2060; -.
DR Antibodypedia; 77550; 3 antibodies from 3 providers.
DR Ensembl; ENST00000418100.6; ENSP00000413411.2; ENSG00000196081.10.
DR MANE-Select; ENST00000418100.6; ENSP00000413411.2; NM_001355404.2; NP_001342333.1.
DR UCSC; uc060wjr.1; human.
DR GeneCards; ZNF724; -.
DR HGNC; HGNC:32460; ZNF724.
DR HPA; ENSG00000196081; Tissue enhanced (bone marrow, esophagus).
DR neXtProt; NX_A8MTY0; -.
DR OpenTargets; ENSG00000196081; -.
DR VEuPathDB; HostDB:ENSG00000196081; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000154251; -.
DR HOGENOM; CLU_002678_44_0_1; -.
DR InParanoid; A8MTY0; -.
DR OMA; SICSTFM; -.
DR PhylomeDB; A8MTY0; -.
DR TreeFam; TF342117; -.
DR PathwayCommons; A8MTY0; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; A8MTY0; -.
DR ChiTaRS; ZNF724; human.
DR Pharos; A8MTY0; Tdark.
DR PRO; PR:A8MTY0; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; A8MTY0; protein.
DR Bgee; ENSG00000196081; Expressed in ganglionic eminence and 100 other tissues.
DR ExpressionAtlas; A8MTY0; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 14.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 16.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 9.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 16.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..619
FT /note="Zinc finger protein 724"
FT /id="PRO_0000332283"
FT DOMAIN 4..75
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 170..192
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 198..220
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 226..248
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 254..276
FT /note="C2H2-type 4; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 282..304
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 310..332
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 338..360
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 366..388
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 394..416
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 422..444
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 450..472
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 478..500
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 506..528
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 534..556
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 562..584
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 590..612
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CONFLICT 525
FT /note="K -> R (in Ref. 1; BAG62802)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 619 AA; 71172 MW; 7E1F76A81721C9B4 CRC64;
MGPLTFMDVA IEFSVEEWQC LDTAQQNLYR NVMLENYRNL VFLGIAVSKP DLITCLEQGK
EPWNMERHEM VAKPPGMCCY FAQDLRPEQS IKASLQRIIL RKYEKCGHHN LQLKKGYKSV
DEYKVHKGSY NGFNQCLTTT QSKIFQCDKY VKDFHKFSNS NRHKTEKNPF KCKECGKSFC
VLSHLTQHKR IHTTVNSYKL EECGKAFNVS STLSQHKRIH TGQKHYKCEE CGIAFNKSSH
LNTHKIIHTG EKSYKREECG KAFNISSHLT THKIIHTGEN AYKCKECGKA FNQSSTLTRH
KIIHAGEKPY ICEHCGRAFN QSSNLTKHKR IHTGDKPYKC EECGKAFNVS STLTQHKRIH
TGEKPYKCEE CGKAFNVSST LTQHKRIHTG EKPYKCEECG KAFNTSSHLT THKRIHTGEK
PYKCEECGKA FNQFSQLTTH KIIHTGEKPY KCKECGKAFK RSSNLTEHRI IHTGEKPYKC
EECGKAFNLS SHLTTHKKIH TGEKPYKCKE CGKAFNQSST LARHKIIHAG EKPYKCEECG
KAFYQYSNLT QHKIIHTGEK PYKCEECGKA FNWSSTLTKH KVIHTGEKPY KCKECGKAFN
QCSNLTTHKK IHAVEKSDK
