ZN726_HUMAN
ID ZN726_HUMAN Reviewed; 616 AA.
AC A6NNF4; M0R0X8; Q86Y87;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-SEP-2021, sequence version 5.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Zinc finger protein 726 {ECO:0000305};
GN Name=ZNF726 {ECO:0000312|HGNC:HGNC:32462};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- INTERACTION:
CC A6NNF4-2; Q9UHV9: PFDN2; NbExp=3; IntAct=EBI-18338284, EBI-359873;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=3;
CC IsoId=A6NNF4-3; Sequence=Displayed;
CC Name=2;
CC IsoId=A6NNF4-2; Sequence=VSP_061120;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AC011503; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC046415; AAH46415.2; -; mRNA.
DR CCDS; CCDS59372.1; -. [A6NNF4-3]
DR RefSeq; NP_001230967.1; NM_001244038.1. [A6NNF4-3]
DR RefSeq; NP_001335618.1; NM_001348689.1. [A6NNF4-2]
DR AlphaFoldDB; A6NNF4; -.
DR SMR; A6NNF4; -.
DR BioGRID; 610475; 10.
DR IntAct; A6NNF4; 1.
DR STRING; 9606.ENSP00000471516; -.
DR iPTMnet; A6NNF4; -.
DR PhosphoSitePlus; A6NNF4; -.
DR BioMuta; ZNF726; -.
DR jPOST; A6NNF4; -.
DR MassIVE; A6NNF4; -.
DR PaxDb; A6NNF4; -.
DR PRIDE; A6NNF4; -.
DR ProteomicsDB; 1606; -. [A6NNF4-2]
DR Antibodypedia; 77920; 3 antibodies from 3 providers.
DR DNASU; 730087; -.
DR Ensembl; ENST00000594466.6; ENSP00000471516.1; ENSG00000213967.12. [A6NNF4-3]
DR GeneID; 730087; -.
DR KEGG; hsa:730087; -.
DR MANE-Select; ENST00000594466.6; ENSP00000471516.1; NM_001244038.2; NP_001230967.1.
DR UCSC; uc021urw.2; human. [A6NNF4-3]
DR CTD; 730087; -.
DR GeneCards; ZNF726; -.
DR HGNC; HGNC:32462; ZNF726.
DR HPA; ENSG00000213967; Low tissue specificity.
DR neXtProt; NX_A6NNF4; -.
DR OpenTargets; ENSG00000213967; -.
DR VEuPathDB; HostDB:ENSG00000213967; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000153236; -.
DR HOGENOM; CLU_002678_69_11_1; -.
DR InParanoid; A6NNF4; -.
DR OMA; CVIVHER; -.
DR OrthoDB; 1318335at2759; -.
DR PathwayCommons; A6NNF4; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; A6NNF4; -.
DR BioGRID-ORCS; 730087; 9 hits in 1092 CRISPR screens.
DR ChiTaRS; ZNF726; human.
DR GenomeRNAi; 730087; -.
DR Pharos; A6NNF4; Tdark.
DR PRO; PR:A6NNF4; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; A6NNF4; protein.
DR Bgee; ENSG00000213967; Expressed in ventricular zone and 96 other tissues.
DR ExpressionAtlas; A6NNF4; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 14.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 15.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 9.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 16.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 19.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..616
FT /note="Zinc finger protein 726"
FT /id="PRO_0000340682"
FT DOMAIN 4..75
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 173..195
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 201..223
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 229..251
FT /note="C2H2-type 3; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 257..279
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 285..307
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 313..335
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 341..363
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 369..391
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 397..419
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 425..447
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 453..475
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 481..503
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 509..531
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 537..559
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 565..587
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 593..615
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 78..616
FT /note="Missing (in isoform 2)"
FT /id="VSP_061120"
FT CONFLICT 77
FT /note="I -> R (in Ref. 2; AAH46415)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 616 AA; 71359 MW; F93DB0E02A2C04DA CRC64;
MGLLTFRDVA IEFSLEEWQC LDTAQKNLYR NVMLENYRNL AFLGIAVSKP DLIICLEKEK
EPWNMKRDEM VDEPPGICPH FAQDIWPEQG VEDSFQKVIL RRFEKCGHEN LQLRKGCKSV
DECKVHKEGY NGLNQCFTTT QGKASQCGKY LKVFYKFINL NRYKIRHTRK KPFKCKNCVK
SFCMFSHKTQ HKSIYTTEKS YKCKECGKTF NWSSTLTNHK KTHTEEKPYK CEEYGKAFNQ
SSNYTTHKVT HTGEKPYKCE ECGKAFSQSS TLTIHKRIHT GEKPCKCEEC GKAFSQPSAL
TIHKRMHIGE KPYKCEECGK AFVWSSTLTR HKRLHSGEKP YKCEECAKAF SQFGHLTTHR
IIHTGEKPYK CEECGKAFIW PSTLTKHKRI HTGEKPYKCE ECGKAFHRSS NLTKHKIIHT
GEKPYKCEEC GKAFIWSSNL TEHKKIHTRE KPYKCEECSK AFSRSSALTT HKRMHTGEKP
YKCEECGKAF SQSSTLTAHK IIHTGEKPYK CEECGKAFIL SSTLSKHKRI HTGEKPYKCE
ECGKTFNQSS NLSTHKIIHT GEKPYKCEEC GKAFNRSSNL STHKIIHTGE KPYKCDECGK
SFIWSSTLFK HKRIHT
