ID   ZN727_HUMAN             Reviewed;         499 AA.
AC   A8MUV8;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 3.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Putative zinc finger protein 727;
DE   AltName: Full=Zinc finger protein 727 pseudogene;
GN   Name=ZNF727; Synonyms=ZNF727P;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
CC   -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; AC115220; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS55113.1; -.
DR   RefSeq; NP_001152994.1; NM_001159522.1.
DR   AlphaFoldDB; A8MUV8; -.
DR   SMR; A8MUV8; -.
DR   BioGRID; 138203; 2.
DR   STRING; 9606.ENSP00000485448; -.
DR   iPTMnet; A8MUV8; -.
DR   PhosphoSitePlus; A8MUV8; -.
DR   BioMuta; ZNF727; -.
DR   jPOST; A8MUV8; -.
DR   MassIVE; A8MUV8; -.
DR   PaxDb; A8MUV8; -.
DR   PeptideAtlas; A8MUV8; -.
DR   PRIDE; A8MUV8; -.
DR   ProteomicsDB; 2136; -.
DR   DNASU; 442319; -.
DR   Ensembl; ENST00000456806.3; ENSP00000485448.1; ENSG00000214652.6.
DR   GeneID; 442319; -.
DR   KEGG; hsa:442319; -.
DR   MANE-Select; ENST00000456806.3; ENSP00000485448.1; NM_001159522.3; NP_001152994.1.
DR   UCSC; uc011kdm.2; human.
DR   CTD; 442319; -.
DR   DisGeNET; 442319; -.
DR   GeneCards; ZNF727; -.
DR   HGNC; HGNC:22785; ZNF727.
DR   HPA; ENSG00000214652; Low tissue specificity.
DR   neXtProt; NX_A8MUV8; -.
DR   PharmGKB; PA162410231; -.
DR   VEuPathDB; HostDB:ENSG00000214652; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000154251; -.
DR   HOGENOM; CLU_002678_44_0_1; -.
DR   InParanoid; A8MUV8; -.
DR   OMA; HEIYAKE; -.
DR   OrthoDB; 1318335at2759; -.
DR   PhylomeDB; A8MUV8; -.
DR   TreeFam; TF342117; -.
DR   PathwayCommons; A8MUV8; -.
DR   Reactome; R-HSA-212436; Generic Transcription Pathway.
DR   SignaLink; A8MUV8; -.
DR   BioGRID-ORCS; 442319; 8 hits in 982 CRISPR screens.
DR   ChiTaRS; ZNF727; human.
DR   GenomeRNAi; 442319; -.
DR   Pharos; A8MUV8; Tdark.
DR   PRO; PR:A8MUV8; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; A8MUV8; protein.
DR   Bgee; ENSG00000214652; Expressed in oviduct epithelium and 148 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 5.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 10.
DR   SUPFAM; SSF109640; SSF109640; 1.
DR   SUPFAM; SSF57667; SSF57667; 7.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE   5: Uncertain;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..499
FT                   /note="Putative zinc finger protein 727"
FT                   /id="PRO_0000346157"
FT   DOMAIN          4..75
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         143..167
FT                   /note="C2H2-type 1; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         200..222
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         228..250
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         256..278
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         284..306
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         312..334
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         340..362
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         368..390
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         396..418
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         424..446
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         452..474
FT                   /note="C2H2-type 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ   SEQUENCE   499 AA;  57972 MW;  DA3CC3D5F0BFD7A0 CRC64;
     MRVLTFRDVA VEFSPEEWEC LDSAQQRLYR DVMLENYGNL FSLGLAIFKP DLITYLEQRK
     EPWNARRQKT VAKHPAGSLH FTAEILLEHD INDSFQKVIL RKSGSCDLNT LRLKKDYQRV
     GNCKGQKSSY NGIHQCLSAT RSKTCQYNKC GKAFGLCSIF TEHKKIFSRE KCYKCEECGK
     DCRLSDFTIQ KRIHTADRSY KCEECGKACK KFSNLTEHNR VHTGKKPYKC EECGKTFTCS
     SALTKHKRNH TGDRPYKCEE CHKAFRCCSD LTKHKRIHTG EKPYKCKECH KAFRCCSDLT
     KHKRIHTGEK PYKCNECGKA FMWISALSQH NRIHTGEKPY ICEECGKAFT YSSTLISHKR
     IHMELRPYKC EECGKTFKWF SDLTNHKRIH TGEKPYKCEE CGKSFTCSSN LIKHKRIHME
     VRPYKCEECG KTFKWFPDLT NHKRIHTGEK PYKCEECGKT FTCSSSLIKH KRSHTGDRPT
     SAKNVAKPLG GSQTLLNIR