ZN728_HUMAN
ID ZN728_HUMAN Reviewed; 622 AA.
AC P0DKX0;
DT 06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2013, sequence version 1.
DT 03-AUG-2022, entry version 65.
DE RecName: Full=Zinc finger protein 728;
GN Name=ZNF728;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
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DR EMBL; AC011502; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC074135; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS59370.1; -.
DR RefSeq; NP_001254645.1; NM_001267716.1.
DR AlphaFoldDB; P0DKX0; -.
DR SMR; P0DKX0; -.
DR iPTMnet; P0DKX0; -.
DR PhosphoSitePlus; P0DKX0; -.
DR BioMuta; ZNF728; -.
DR DMDM; 449061972; -.
DR EPD; P0DKX0; -.
DR jPOST; P0DKX0; -.
DR MassIVE; P0DKX0; -.
DR MaxQB; P0DKX0; -.
DR PaxDb; P0DKX0; -.
DR PeptideAtlas; P0DKX0; -.
DR PRIDE; P0DKX0; -.
DR DNASU; 388523; -.
DR Ensembl; ENST00000594710.2; ENSP00000471593.1; ENSG00000269067.2.
DR GeneID; 388523; -.
DR KEGG; hsa:388523; -.
DR MANE-Select; ENST00000594710.2; ENSP00000471593.1; NM_001267716.2; NP_001254645.1.
DR UCSC; uc002nqz.3; human.
DR CTD; 388523; -.
DR GeneCards; ZNF728; -.
DR HGNC; HGNC:32463; ZNF728.
DR HPA; ENSG00000269067; Tissue enhanced (testis).
DR neXtProt; NX_P0DKX0; -.
DR OpenTargets; ENSG00000269067; -.
DR VEuPathDB; HostDB:ENSG00000269067; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000153236; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; P0DKX0; -.
DR OMA; KWSSNLM; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; P0DKX0; -.
DR PathwayCommons; P0DKX0; -.
DR BioGRID-ORCS; 388523; 69 hits in 1022 CRISPR screens.
DR GenomeRNAi; 388523; -.
DR Pharos; P0DKX0; Tdark.
DR PRO; PR:P0DKX0; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; P0DKX0; protein.
DR Bgee; ENSG00000269067; Expressed in testis and 96 other tissues.
DR ExpressionAtlas; P0DKX0; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 11.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 9.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
PE 4: Predicted;
KW Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..622
FT /note="Zinc finger protein 728"
FT /id="PRO_0000421023"
FT DOMAIN 4..75
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 228..250
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 256..278
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 284..306
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 312..334
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 340..362
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 368..390
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 396..418
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 424..446
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 452..474
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 480..502
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 508..530
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 536..558
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 564..586
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 592..614
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ SEQUENCE 622 AA; 71801 MW; 3C6857B813210100 CRC64;
MGSLTFRDVA IQFSLEEWQC LDTAQQNLYR NVMLENYRNL VFLGIAAPKP DLIIFLEQGK
EPWNMKRHEL VKEPPVICSH FAQDLWPEQG REDSFQKVIL RRYEKCGHEN LQLKIGCTNV
DECKVHKKGY NKLNQSLTTT QSKVFQCGKY ANIFHKCSNS KRHKIRHTGK KLLKCKEYVR
SFCMLSHLSQ HKRIYTRENS YKSEEHGKAF NWSSALTYKR IHTGEKPCKC EECGKAFSKF
SILTKHKVIH TGEKHYKCEE CGKAFTRSSS LIEHKRSHAG EKPYKCEECG KAFSKASTLT
AHKTIHAGEK PYKCEECGKA FNRSSNLMEH KRIHTGEKPC KCEECGKAFG NFSTLTKHKV
IHTGEKPYKC EECGKAFSWP SSLTEHKRIH AGDKPYKCEE CGKTFKWSST LTKHKIIHTG
EKPYKCEECG KAFTTFSSLT KHKVIHTGEK HYKCEECGKV FSWSSSLTTH KAIHAGEKLY
KCEECGKAFK WSSNLMEHKR IHTGEKPYKC EECGKAFSKV ANLTKHKVIH TGEKQYKCEE
CGKAFIWSSR LSEHKRIHTG EKPYKCEECG KAFSWVSVLN KHKKIHAGKK FYKCEECGKD
FNQSSHLTTH KRIHTGGKTL QM
