ZN728_MOUSE
ID ZN728_MOUSE Reviewed; 752 AA.
AC Q6P5C7;
DT 06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Zinc finger protein 728;
GN Name=Znf728; Synonyms=Zfp458;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AC159264; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC163667; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC062958; AAH62958.1; -; mRNA.
DR CCDS; CCDS36710.1; -.
DR RefSeq; NP_001001152.1; NM_001001152.2.
DR AlphaFoldDB; Q6P5C7; -.
DR SMR; Q6P5C7; -.
DR STRING; 10090.ENSMUSP00000047222; -.
DR PhosphoSitePlus; Q6P5C7; -.
DR PaxDb; Q6P5C7; -.
DR PRIDE; Q6P5C7; -.
DR DNASU; 238690; -.
DR Ensembl; ENSMUST00000045969; ENSMUSP00000047222; ENSMUSG00000055480.
DR GeneID; 238690; -.
DR KEGG; mmu:238690; -.
DR UCSC; uc007ral.1; mouse.
DR CTD; 238690; -.
DR MGI; MGI:3040691; Zfp458.
DR VEuPathDB; HostDB:ENSMUSG00000055480; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000155274; -.
DR HOGENOM; CLU_002678_17_1_1; -.
DR InParanoid; Q6P5C7; -.
DR OMA; PHESENY; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q6P5C7; -.
DR TreeFam; TF343410; -.
DR Reactome; R-MMU-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 238690; 2 hits in 70 CRISPR screens.
DR ChiTaRS; Zfp458; mouse.
DR PRO; PR:Q6P5C7; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q6P5C7; protein.
DR Bgee; ENSMUSG00000055480; Expressed in rostral migratory stream and 182 other tissues.
DR ExpressionAtlas; Q6P5C7; baseline and differential.
DR Genevisible; Q6P5C7; MM.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:MGI.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:MGI.
DR GO; GO:0070895; P:negative regulation of transposon integration; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 15.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 21.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 12.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 20.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 23.
PE 2: Evidence at transcript level;
KW Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..752
FT /note="Zinc finger protein 728"
FT /id="PRO_0000421024"
FT DOMAIN 5..76
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 81..103
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 109..131
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 137..159
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 165..187
FT /note="C2H2-type 4; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 193..215
FT /note="C2H2-type 5; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 221..243
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 249..271
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 277..299
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 305..327
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 333..355
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 361..383
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 389..411
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 417..439
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 445..467
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 473..495
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 501..523
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 529..551
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 557..579
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 585..607
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 641..663
FT /note="C2H2-type 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 669..691
FT /note="C2H2-type 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 697..719
FT /note="C2H2-type 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 725..747
FT /note="C2H2-type 23; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 611..636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 752 AA; 86422 MW; 089C07C95BE43A3A CRC64;
MEDMLSFWDV AIYFSAEEWE CLGPAQWKLY RDVMLENYSN LVFLGLASSK PYLVTFLEQI
QEPSDVKRQA AITVHPGGKC YTCKECGKGF EHKKVYQNHR RIHLRVKSYK CEECGKSFRF
PSLLSAHKRN HTGQKPYNCE ICSKAFHVPS LLSVHKRIHR VQKPYKSEDY GKTLHCPSLL
SQHKIVHTGE KPYQCEDLGK AFRYPSRLSN HKKIHTGEKP HKCEVCGKAF DYPSRLSNHK
RIHTGEKPYK CEVCGKAFHD PSKLSQHKII HTGEKPYKCE VCGKTFHYPS ILSKHKIIHT
KENLCKCDIC GKAFHYPLLL SQHKIVHTGE KPYKCEDCGK AFYYPSRLSR HKKIHTGEKP
YKCEVCGKAF YYLSILSKHM IVHTEENPYK CEVCGKAFDY PSRLSNHKKI HTEDKPHKCE
VCGNAFCFSS SLRKHKIIHT GEKPYKCDIC GKAFGSPSRL SKHNKIHTED KPYKCEVCGK
AFHFPSLLLV HKRIHTGEKP YKCEVCGKAF YCLSTLSVHK RIHTGEYAYK CEVCGKAFHC
LSTLSVHKRI HTQEKPYKCE VCGQAFHASS KLSHHKRIHS GEKPHKCEIC GKSFYYPSRL
SKHKVIHTGE KPYHSQASGK TLDYPSRHSK PKTIKTGEKP NKCEICGKAF SFPSLLSIHK
RIHIGEKPYN CEVCGKAFRN PSRLSNHKKI HTGEKPYKCE ICGKAFDYPS LLSKHKIIHT
GEKPYHSEVC GKAFSYSSRI SKDKKICTGE KP
