ZN729_HUMAN
ID ZN729_HUMAN Reviewed; 1252 AA.
AC A6NN14; M0QY45;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 14-MAY-2014, sequence version 4.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Zinc finger protein 729;
GN Name=ZNF729;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-100.
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AC011494; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC073539; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX956721; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS59368.1; -.
DR RefSeq; NP_001229609.1; NM_001242680.1.
DR AlphaFoldDB; A6NN14; -.
DR SMR; A6NN14; -.
DR STRING; 9606.ENSP00000469582; -.
DR iPTMnet; A6NN14; -.
DR PhosphoSitePlus; A6NN14; -.
DR BioMuta; ZNF729; -.
DR EPD; A6NN14; -.
DR jPOST; A6NN14; -.
DR MassIVE; A6NN14; -.
DR PaxDb; A6NN14; -.
DR PeptideAtlas; A6NN14; -.
DR PRIDE; A6NN14; -.
DR ProteomicsDB; 1578; -.
DR Antibodypedia; 69807; 50 antibodies from 8 providers.
DR DNASU; 100287226; -.
DR Ensembl; ENST00000601693.2; ENSP00000469582.1; ENSG00000196350.9.
DR GeneID; 100287226; -.
DR KEGG; hsa:100287226; -.
DR MANE-Select; ENST00000601693.2; ENSP00000469582.1; NM_001242680.2; NP_001229609.1.
DR UCSC; uc021urs.2; human.
DR CTD; 100287226; -.
DR DisGeNET; 100287226; -.
DR GeneCards; ZNF729; -.
DR HGNC; HGNC:32464; ZNF729.
DR HPA; ENSG00000196350; Tissue enriched (testis).
DR neXtProt; NX_A6NN14; -.
DR OpenTargets; ENSG00000196350; -.
DR VEuPathDB; HostDB:ENSG00000196350; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163381; -.
DR HOGENOM; CLU_002678_17_1_1; -.
DR InParanoid; A6NN14; -.
DR OMA; LGHFNTH; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; A6NN14; -.
DR TreeFam; TF343410; -.
DR PathwayCommons; A6NN14; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 100287226; 18 hits in 989 CRISPR screens.
DR GenomeRNAi; 100287226; -.
DR Pharos; A6NN14; Tdark.
DR PRO; PR:A6NN14; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; A6NN14; protein.
DR Bgee; ENSG00000196350; Expressed in ventricular zone and 4 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 29.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 37.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 20.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 34.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 37.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..1252
FT /note="Zinc finger protein 729"
FT /id="PRO_0000332314"
FT DOMAIN 13..84
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 180..202
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 208..230
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 236..258
FT /note="C2H2-type 3; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 264..286
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 292..314
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 320..342
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 348..370
FT /note="C2H2-type 7; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 376..398
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 404..426
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 432..454
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 460..482
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 488..510
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 516..538
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 544..566
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 572..594
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 600..622
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 628..650
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 656..678
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 684..706
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 712..734
FT /note="C2H2-type 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 740..762
FT /note="C2H2-type 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 768..790
FT /note="C2H2-type 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 796..818
FT /note="C2H2-type 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 824..846
FT /note="C2H2-type 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 852..874
FT /note="C2H2-type 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 880..902
FT /note="C2H2-type 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 908..930
FT /note="C2H2-type 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 936..958
FT /note="C2H2-type 28"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 964..986
FT /note="C2H2-type 29"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 992..1014
FT /note="C2H2-type 30"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1020..1042
FT /note="C2H2-type 31"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1048..1070
FT /note="C2H2-type 32"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1076..1098
FT /note="C2H2-type 33"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1104..1126
FT /note="C2H2-type 34"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1132..1154
FT /note="C2H2-type 35"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1160..1182
FT /note="C2H2-type 36"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1188..1210
FT /note="C2H2-type 37"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ SEQUENCE 1252 AA; 145022 MW; DA92ED8A0114DE8F CRC64;
MPGAPGSLEM GPLTFRDVTI EFSLEEWQCL DTVQQNLYRD VMLENYRNLV FLGMAVFKPD
LITCLKQGKE PWNMKRHEMV TKPPVMRSHF TQDLWPDQST KDSFQEVILR TYARCGHKNL
RLRKDCKSAN EGKMHKEGYN KLNQCRTATQ RKIFQCNKHM KVFHKYSNRN KVRHTKKKTF
KCIKCSKSFF MLSCLIRHKR IHIRQNIYKC EERGKAFKSF STLTKHKIIH TEDKPYKYKK
CGNAFKFSST FTKHKRIHTG ETPFRCEECG KAFNQSSNLT DHKRIHTGEK TYKCEECGKA
FKGSSNFNAH KVIHTAEKPY KCEDCGKTFN HFSALRKHKI IHTGKKPYKR EECGKAFSQS
STLRKHEIIH TGEKPYKCEE CGKAFKWSSK LTVHKVVHTG EKPYKCEECG KAFSQFSTLK
KHKIIHTGKK PYKCEECGKA FNSSSTLMKH KIIHTGEKPY KCEECGKAFR QSSHLTRHKA
IHTGEKPYKC EECGKAFNHF SDLRRHKIIH TGKKPYKCEE CGKAFSQSST LRNHQIIHTG
EKPYKCEECG KAFKWSSKLT VHKVIHTGEK PCKCEECGKA FKHFSALRKH KVIHTREKLY
KCEECGKAFN NSSILAKHKI IHTGKKPYKC EECGKAFRQS SHLTRHKAIH TGEKPYKCEE
CGKAFSHFSA LRRHKIIHTG KKPYKCEECG KAFSHFSALR RHKIIHTGEK PYKCEECGKA
FKWSSKLTVH KVIHTAEKPC KCEECGKSFK HFSALRKHKV IHTREKLYKC EECVKAFNSF
SALMKHKVIH TGEKPYKCEE CGKAFKWSSK LTVHKVIHTG EKPCKCEECG KAFKHFSALR
KHKVIHTGKK PYKCEECGKA FSQSSSLRKH EIIHSGEKPY KCEECGKAFK WLSKLTVHKV
IHTAEKPCKC EECGKAFKHF SALRKHKIIH TGKKPYKCEE CGKAFNDSST LMKHKIIHTG
KKPYKCAECG KAFKQSSHLT RHKAIHTGEK PYKCEECGKD FNNSSTLKKH KLIHTREKLY
KCEECVKAFN NFSALMKHKI IHTGEKPYKC EECGKAFKWS SKLTEHKVIH TGEKPCKCEE
CDKAFKHFSA LRKHKVIHTG KKPYQCDECG KAFNNSSTLT KHKIIHTGEK PYKCEECGKA
FSQSSILTKH KIIHSVEKPY KCEECGKAFN QSSHLTRHKT IHTGEKPYKC EECGKAFIQC
SYLIRHKTIH TREKPTNVKK VPKLLSNPHT LLDKTIHTGE KPYKCEECAK AF
