ZN730_HUMAN
ID ZN730_HUMAN Reviewed; 503 AA.
AC Q6ZMV8;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Putative zinc finger protein 730;
GN Name=ZNF730;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK131472; BAD18617.1; -; mRNA.
DR CCDS; CCDS59371.1; -.
DR RefSeq; NP_001264332.1; NM_001277403.1.
DR AlphaFoldDB; Q6ZMV8; -.
DR SMR; Q6ZMV8; -.
DR STRING; 9606.ENSP00000472959; -.
DR iPTMnet; Q6ZMV8; -.
DR PhosphoSitePlus; Q6ZMV8; -.
DR BioMuta; ZNF730; -.
DR DMDM; 74758685; -.
DR EPD; Q6ZMV8; -.
DR jPOST; Q6ZMV8; -.
DR MassIVE; Q6ZMV8; -.
DR MaxQB; Q6ZMV8; -.
DR PaxDb; Q6ZMV8; -.
DR PeptideAtlas; Q6ZMV8; -.
DR PRIDE; Q6ZMV8; -.
DR ProteomicsDB; 67923; -.
DR DNASU; 100129543; -.
DR Ensembl; ENST00000597761.7; ENSP00000472959.1; ENSG00000183850.14.
DR GeneID; 100129543; -.
DR KEGG; hsa:100129543; -.
DR MANE-Select; ENST00000597761.7; ENSP00000472959.1; NM_001277403.2; NP_001264332.1.
DR UCSC; uc031rkc.2; human.
DR CTD; 100129543; -.
DR DisGeNET; 100129543; -.
DR GeneCards; ZNF730; -.
DR HGNC; HGNC:32470; ZNF730.
DR HPA; ENSG00000183850; Tissue enhanced (brain, testis).
DR neXtProt; NX_Q6ZMV8; -.
DR OpenTargets; ENSG00000183850; -.
DR VEuPathDB; HostDB:ENSG00000183850; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT01050000244908; -.
DR HOGENOM; CLU_002678_44_0_1; -.
DR InParanoid; Q6ZMV8; -.
DR OMA; PVICSHI; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q6ZMV8; -.
DR TreeFam; TF342117; -.
DR PathwayCommons; Q6ZMV8; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q6ZMV8; -.
DR BioGRID-ORCS; 100129543; 90 hits in 995 CRISPR screens.
DR ChiTaRS; ZNF730; human.
DR GenomeRNAi; 100129543; -.
DR Pharos; Q6ZMV8; Tdark.
DR PRO; PR:Q6ZMV8; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q6ZMV8; protein.
DR Bgee; ENSG00000183850; Expressed in ganglionic eminence and 93 other tissues.
DR ExpressionAtlas; Q6ZMV8; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 8.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..503
FT /note="Putative zinc finger protein 730"
FT /id="PRO_0000328986"
FT DOMAIN 4..75
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 145..167
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 173..195
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 228..250
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 256..278
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 284..306
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 312..334
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 340..362
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 368..390
FT /note="C2H2-type 8; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 396..418
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 424..446
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 452..474
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 480..502
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 365
FT /note="G -> E (in dbSNP:rs7247102)"
FT /id="VAR_057449"
SQ SEQUENCE 503 AA; 59040 MW; EE2CE28DD60B55E3 CRC64;
MGALTFRDVA IEFSLEEWQC LDTEQQNLYR NVMLDNYRNL VFLGIAVSKP DLITCLEQEK
EPWNLKTHDM VAKPPVICSH IAQDLWPEQG IKDYFQEVIL RQYKKCRHEN LLLRKGCKNV
DEFKMHKKGY NRHNQCLTTS HSKIFQCDKY VKVFHKFSNS NRHKIRHTSK KPFKCKECGK
LFCILSHLAQ HKKIHTGEKS YKCEEYGKAF NESSNCTTHK RITEKKPYKC KECGKAFNWF
SHFTTHKRIH TGEKPYQCEK CGKFFNQSTN LTTHKRIHTG EKPYKCEECG KAFNQSSNLT
EHKKIHTKEQ PYKCEKCGKA FKWSSTLTKH KRIHNGEKPY KCEECGKAFN RSSTLNRHKI
THTGGKPYKY KECGKAFNQS STLTIHKIIH TVEKFYKCEE CGKAFSRISH LTTHKRIHTG
EKPYKCEECG RAFNQSSTLT THKRIHTGEK PYECEECGKA FNRSSTLTTH KIIHSGEKIY
KCKECGKAFR RFSHLTRHKT IHT
