ZN735_HUMAN
ID ZN735_HUMAN Reviewed; 412 AA.
AC P0CB33;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Putative zinc finger protein 735;
DE AltName: Full=Zinc finger protein 735 pseudogene;
GN Name=ZNF735; Synonyms=ZNF735P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; AC073270; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC104094; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS78236.1; -.
DR RefSeq; NP_001152996.1; NM_001159524.1.
DR AlphaFoldDB; P0CB33; -.
DR SMR; P0CB33; -.
DR BioGRID; 610679; 1.
DR STRING; 9606.ENSP00000485193; -.
DR iPTMnet; P0CB33; -.
DR PhosphoSitePlus; P0CB33; -.
DR BioMuta; ZNF735; -.
DR DMDM; 259710468; -.
DR jPOST; P0CB33; -.
DR MassIVE; P0CB33; -.
DR MaxQB; P0CB33; -.
DR PeptideAtlas; P0CB33; -.
DR PRIDE; P0CB33; -.
DR ProteomicsDB; 52432; -.
DR Antibodypedia; 74087; 26 antibodies from 8 providers.
DR DNASU; 730291; -.
DR Ensembl; ENST00000429565.4; ENSP00000485547.1; ENSG00000223614.5.
DR GeneID; 730291; -.
DR KEGG; hsa:730291; -.
DR MANE-Select; ENST00000429565.5; ENSP00000485547.1; NM_001159524.1; NP_001152996.1.
DR UCSC; uc011kdn.3; human.
DR CTD; 730291; -.
DR GeneCards; ZNF735; -.
DR HGNC; HGNC:32466; ZNF735.
DR HPA; ENSG00000223614; Not detected.
DR neXtProt; NX_P0CB33; -.
DR PharmGKB; PA162410268; -.
DR VEuPathDB; HostDB:ENSG00000223614; -.
DR GeneTree; ENSGT00940000153236; -.
DR HOGENOM; CLU_002678_0_10_1; -.
DR InParanoid; P0CB33; -.
DR OMA; QNMKRSE; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; P0CB33; -.
DR PathwayCommons; P0CB33; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 730291; 8 hits in 200 CRISPR screens.
DR ChiTaRS; ZNF735; human.
DR GenomeRNAi; 730291; -.
DR Pharos; P0CB33; Tdark.
DR PRO; PR:P0CB33; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; P0CB33; protein.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 6.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 5.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 5: Uncertain;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..412
FT /note="Putative zinc finger protein 735"
FT /id="PRO_0000383475"
FT DOMAIN 16..87
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 157..179
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 185..207
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 213..235
FT /note="C2H2-type 3; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 241..263
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 269..291
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 297..319
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 325..347
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 353..375
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 381..403
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ SEQUENCE 412 AA; 47565 MW; 2E53E51DC216A02F CRC64;
MAKRPGPPGS REMGLLTFRD IAIEFSLAEW QCLDHAQQNL YRDVMLENYR NLFSLGMTVS
KPDLIACLEQ NKEPQNIKRN EMAAKHPVTC SHFNQDLQPE QSIKDSLQKV IPRTYGKCGH
ENLQLKKCCK RVDECEVHKG GYNDLNQCLS NTQNKIFQTH KCVKVFSKFS NSNRHNARYT
GKKHLKCKKY GKSFCMFSHL NQHQIIHTKE KSYKCEECGK SFNHSSSGTT HKRILTGEKP
YRCEECGKAF RWPSNLTRHK RIHTGEKPYA CEECGQAFRR SSTLTNHKRI HTGERPYKCE
ECGKAFSVSS ALIYHKRIHT GEKPYTCEEC GKAFNCSSTL KTHKIIHTGE KPYTCEECGR
TFNCSSTVKA HKRIHTGEKP YKCEECDKAF KWHSSLAKHK IIHTGEKPYK CK
