ZN736_HUMAN
ID ZN736_HUMAN Reviewed; 427 AA.
AC B4DX44;
DT 13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 2.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Zinc finger protein 736;
GN Name=ZNF736;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK301806; BAG63256.1; -; mRNA.
DR EMBL; AC073270; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS55114.1; -.
DR RefSeq; NP_001164376.1; NM_001170905.2.
DR AlphaFoldDB; B4DX44; -.
DR SMR; B4DX44; -.
DR BioGRID; 609336; 1.
DR IntAct; B4DX44; 2.
DR STRING; 9606.ENSP00000400852; -.
DR iPTMnet; B4DX44; -.
DR PhosphoSitePlus; B4DX44; -.
DR BioMuta; ZNF736; -.
DR jPOST; B4DX44; -.
DR MassIVE; B4DX44; -.
DR PaxDb; B4DX44; -.
DR PeptideAtlas; B4DX44; -.
DR PRIDE; B4DX44; -.
DR ProteomicsDB; 5408; -.
DR Antibodypedia; 67605; 73 antibodies from 14 providers.
DR DNASU; 728927; -.
DR Ensembl; ENST00000355095.8; ENSP00000347210.4; ENSG00000234444.10.
DR Ensembl; ENST00000423484.3; ENSP00000400852.1; ENSG00000234444.10.
DR GeneID; 728927; -.
DR KEGG; hsa:728927; -.
DR MANE-Select; ENST00000423484.3; ENSP00000400852.1; NM_001170905.3; NP_001164376.1.
DR UCSC; uc003tsz.5; human.
DR CTD; 728927; -.
DR GeneCards; ZNF736; -.
DR HGNC; HGNC:32467; ZNF736.
DR HPA; ENSG00000234444; Low tissue specificity.
DR neXtProt; NX_B4DX44; -.
DR OpenTargets; ENSG00000234444; -.
DR VEuPathDB; HostDB:ENSG00000234444; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000154251; -.
DR HOGENOM; CLU_002678_44_0_1; -.
DR InParanoid; B4DX44; -.
DR OMA; ITHSKTC; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; B4DX44; -.
DR TreeFam; TF342117; -.
DR PathwayCommons; B4DX44; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; B4DX44; -.
DR BioGRID-ORCS; 728927; 13 hits in 1023 CRISPR screens.
DR ChiTaRS; ZNF736; human.
DR GenomeRNAi; 728927; -.
DR Pharos; B4DX44; Tdark.
DR PRO; PR:B4DX44; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; B4DX44; protein.
DR Bgee; ENSG00000234444; Expressed in epithelial cell of pancreas and 159 other tissues.
DR ExpressionAtlas; B4DX44; baseline and differential.
DR Genevisible; B4DX44; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..427
FT /note="Zinc finger protein 736"
FT /id="PRO_0000395343"
FT DOMAIN 4..75
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 145..167
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 173..195
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 201..223
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 229..251
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 257..279
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 285..307
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 313..335
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 341..363
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 369..391
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 397..419
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CONFLICT 268
FT /note="C -> R (in Ref. 1; BAG63256)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 427 AA; 49868 MW; 6C26A8CCF635DD88 CRC64;
MGVLTFRDVA VEFSPEEWEC LDSAQQRLYR DVMLENYGNL VSLGLAIFKP DLMTCLEQRK
EPWKVKRQEA VAKHPAGSFH FTAEILPDHD IKDSFQKVIL RKYGSCDLNN LHLKKDYQSV
GNCKGQKSSY NGLHQCLSAT HSKTCQCNKC GRGFQLCSIF TEHKDIFSRE KCHKCEECGK
DCRLFSDFTR HKKIHTVERC YKCEECGKAF KKFSNLTEHK RVHTGEKPYK CEGCGKTFTC
SSTLVKHKRN HTGDRPYKCE ECGKAFKCFS DLTNHKRIHT GEKPYKCEEC NKAYRWFSDL
AKHKIIHTGD KPYTCNECGK AFKWFSALSK HKRIHTGEKP YICEECGKAF TRSSTLFNHK
RIHMEERPYK CEECSKTFKC FSDLTNHKRI HTGEKPYKCE ECGKASSWFS HLIRHKRIHT
REKLHKC
