ZN737_HUMAN
ID ZN737_HUMAN Reviewed; 536 AA.
AC O75373; C9JHM3;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2012, sequence version 3.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Zinc finger protein 737;
DE AltName: Full=Zinc finger protein 102;
GN Name=ZNF737; Synonyms=ZNF102;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLU-516.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 90-154.
RX PubMed=8467795; DOI=10.1002/j.1460-2075.1993.tb05781.x;
RA Bellefroid E.J., Marine J.-C., Ried T., Lecocq P.J., Riviere M.,
RA Amemiya C.T., Poncelet D.A., Coulie P.G., de Jong P.J., Szpirer C.,
RA Ward D.C., Martial J.A.;
RT "Clustered organization of homologous KRAB zinc-finger genes with enhanced
RT expression in human T lymphoid cells.";
RL EMBO J. 12:1363-1374(1993).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AC008554; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC010636; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC015765; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AF044026; AAC25694.1; -; Genomic_DNA.
DR CCDS; CCDS54238.1; -.
DR RefSeq; NP_001152765.1; NM_001159293.1.
DR AlphaFoldDB; O75373; -.
DR SMR; O75373; -.
DR BioGRID; 877828; 1.
DR IntAct; O75373; 1.
DR MINT; O75373; -.
DR STRING; 9606.ENSP00000395733; -.
DR iPTMnet; O75373; -.
DR PhosphoSitePlus; O75373; -.
DR BioMuta; ZNF737; -.
DR EPD; O75373; -.
DR jPOST; O75373; -.
DR MassIVE; O75373; -.
DR MaxQB; O75373; -.
DR PaxDb; O75373; -.
DR PeptideAtlas; O75373; -.
DR PRIDE; O75373; -.
DR ProteomicsDB; 49947; -.
DR Antibodypedia; 67955; 67 antibodies from 12 providers.
DR DNASU; 100129842; -.
DR Ensembl; ENST00000427401.9; ENSP00000395733.3; ENSG00000237440.9.
DR GeneID; 100129842; -.
DR KEGG; hsa:100129842; -.
DR MANE-Select; ENST00000427401.9; ENSP00000395733.3; NM_001159293.2; NP_001152765.1.
DR UCSC; uc002npa.4; human.
DR CTD; 100129842; -.
DR GeneCards; ZNF737; -.
DR HGNC; HGNC:32468; ZNF737.
DR HPA; ENSG00000237440; Low tissue specificity.
DR MIM; 603984; gene.
DR neXtProt; NX_O75373; -.
DR OpenTargets; ENSG00000237440; -.
DR VEuPathDB; HostDB:ENSG00000237440; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT01050000244908; -.
DR HOGENOM; CLU_002678_44_0_1; -.
DR InParanoid; O75373; -.
DR OMA; CGSMFRT; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; O75373; -.
DR TreeFam; TF342117; -.
DR PathwayCommons; O75373; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 100129842; 11 hits in 1031 CRISPR screens.
DR GenomeRNAi; 100129842; -.
DR Pharos; O75373; Tdark.
DR PRO; PR:O75373; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; O75373; protein.
DR Bgee; ENSG00000237440; Expressed in corpus callosum and 103 other tissues.
DR ExpressionAtlas; O75373; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 11.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..536
FT /note="Zinc finger protein 737"
FT /id="PRO_0000340686"
FT DOMAIN 4..75
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 173..195
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 201..223
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 229..251
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 257..279
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 285..307
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 313..335
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 341..363
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 369..391
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 397..419
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 425..447
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 453..475
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 481..503
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 509..531
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 78
FT /note="C -> S (in dbSNP:rs7254995)"
FT /id="VAR_067460"
FT VARIANT 125
FT /note="V -> L (in dbSNP:rs9653154)"
FT /id="VAR_067461"
FT VARIANT 492
FT /note="R -> C (in dbSNP:rs10410201)"
FT /id="VAR_067462"
FT VARIANT 516
FT /note="K -> E (in dbSNP:rs10411329)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_067463"
SQ SEQUENCE 536 AA; 61931 MW; 3DC80FAE59F86C00 CRC64;
MGPLQFRDVA IEFSLEEWHC LDTAQRNLYR NVMLENYRNL VFLGIVVSKP DLITCLEQGK
KPLTMKKHEM VANPSVTCSH FARDLWPEQS IKDSFQKVTL RRYENYGHDN LQFKKGCESV
DECKVHKRGY NGLNQYLTTT QSKIFQCDKY VKVIHKFSNS NRHKIRHTGK KPFKCIECGK
AFNQSSTLTT HKKIHTGEKP FKCEECGKAF NWSSHLTTHK RIHTGEKRYK CEDCGKAFSR
FSYLTAHKII HSGEKPYKCE ECGKAFKRSS NLTTHKIIHT GEKPYKCEEC GKAFKRSSIL
TAHKIIHSGE KPYKCEECGK AFKHPSVLTT HKRIHTGEKP YKCEECGRAF KYFSSLTTHK
IIHSGEKPYK CEECGKAFNW SSHLTTHKRI HTGEKPYKCE ECGEAFKYSS SLTTHKIIHT
GQQPFKCEEC GKAFKCFSIL TTHKRIHTGE KPYKCEECGK AFNSSSHLTA HKRIHTGEKP
YKCERCGKAF KRSFILTRHK RIHTGEKPYK CEECGKGFKC PSTLTTHKVI HTGEKL
