ZN738_HUMAN
ID ZN738_HUMAN Reviewed; 375 AA.
AC Q8NE65; A8K4N7;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-FEB-2022, sequence version 2.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Zinc finger protein 738 {ECO:0000312|HGNC:HGNC:32469};
GN Name=ZNF738 {ECO:0000312|HGNC:HGNC:32469};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8NE65-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NE65-2; Sequence=VSP_061287, VSP_061288;
CC -!- MISCELLANEOUS: [Isoform 1]: Gene prediction based on partial EST data.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK291002; BAF83691.1; -; mRNA.
DR EMBL; AK291193; BAF83882.1; -; mRNA.
DR EMBL; AC010615; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC022432; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS86732.1; -. [Q8NE65-2]
DR AlphaFoldDB; Q8NE65; -.
DR SMR; Q8NE65; -.
DR STRING; 9606.ENSP00000311957; -.
DR iPTMnet; Q8NE65; -.
DR PhosphoSitePlus; Q8NE65; -.
DR BioMuta; ZNF738; -.
DR DMDM; 74730211; -.
DR EPD; Q8NE65; -.
DR jPOST; Q8NE65; -.
DR MassIVE; Q8NE65; -.
DR PaxDb; Q8NE65; -.
DR PeptideAtlas; Q8NE65; -.
DR PRIDE; Q8NE65; -.
DR ProteomicsDB; 73129; -.
DR Antibodypedia; 74048; 21 antibodies from 5 providers.
DR Ensembl; ENST00000311015.7; ENSP00000311957.3; ENSG00000172687.14. [Q8NE65-2]
DR Ensembl; ENST00000683779.1; ENSP00000507366.1; ENSG00000172687.14. [Q8NE65-1]
DR MANE-Select; ENST00000683779.1; ENSP00000507366.1; NM_001355237.2; NP_001342166.1.
DR UCSC; uc002nps.5; human. [Q8NE65-1]
DR GeneCards; ZNF738; -.
DR HGNC; HGNC:32469; ZNF738.
DR HPA; ENSG00000172687; Low tissue specificity.
DR neXtProt; NX_Q8NE65; -.
DR OpenTargets; ENSG00000172687; -.
DR VEuPathDB; HostDB:ENSG00000172687; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000154251; -.
DR HOGENOM; CLU_166510_0_0_1; -.
DR InParanoid; Q8NE65; -.
DR PhylomeDB; Q8NE65; -.
DR TreeFam; TF342644; -.
DR PathwayCommons; Q8NE65; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR ChiTaRS; ZNF738; human.
DR Pharos; Q8NE65; Tdark.
DR PRO; PR:Q8NE65; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8NE65; protein.
DR Bgee; ENSG00000172687; Expressed in oocyte and 165 other tissues.
DR ExpressionAtlas; Q8NE65; baseline and differential.
DR Genevisible; Q8NE65; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; ISS:UniProtKB.
DR GO; GO:0000209; P:protein polyubiquitination; ISS:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 4.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 6.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..375
FT /note="Zinc finger protein 738"
FT /id="PRO_0000274879"
FT DOMAIN 35..106
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 176..198
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 204..226
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 232..254
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 260..282
FT /note="C2H2-type 4; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 288..310
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 316..338
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 344..366
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 106..137
FT /note="PVTYSHFAQDLWPQPGIKDSFQKVILREYGNY -> PESGVLKFPTIIILLS
FT RCFFQSVNICFIYLEP (in isoform 2)"
FT /id="VSP_061287"
FT VAR_SEQ 138..375
FT /note="Missing (in isoform 2)"
FT /id="VSP_061288"
SQ SEQUENCE 375 AA; 43875 MW; DE639B5DA9C05F43 CRC64;
MDDLRYGVYP VKGASGYPGA ERNLLEYSYF EKGPLTFRDV VIEFSQEEWQ CLDTAQQDLY
RKVMLENFRN LVFLGIDVSK PDLITCLEQG KDPWNMKRHS MVATPPVTYS HFAQDLWPQP
GIKDSFQKVI LREYGNYGHK DLQLRKGCKS VNECNVQKEG YNELKEYLTT TQSKIFQCDK
YVKVFHKFLN SNTHKTRHTG KKPFKCKKCG KSFCMLLHLG QHKIIHIREN SYQCEECGKA
FKWFSTLTRH KRIHTGDKSY KHEECGKGFN HSTTLTRHKV IHAGEKHYKC EKCGKDFKQS
SHLTKHKTIH AGEKPYKCEG CGKAFCQFSY LTKHKIIHTG EKPYKCEECG KAFNWYSHLT
RHKIIHTGEK PYKCE
