ZN740_MOUSE
ID ZN740_MOUSE Reviewed; 180 AA.
AC Q6NZQ6; Q3UMS3; Q8JZR3;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Zinc finger protein 740;
GN Name=Znf740; Synonyms=Zfp740;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Brain, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q6NZQ6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6NZQ6-2; Sequence=VSP_020757;
CC Name=3;
CC IsoId=Q6NZQ6-3; Sequence=VSP_020756, VSP_020758;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK144707; BAE26025.1; -; mRNA.
DR EMBL; BC030410; AAH30410.1; -; mRNA.
DR EMBL; BC066011; AAH66011.1; -; mRNA.
DR CCDS; CCDS70672.1; -. [Q6NZQ6-1]
DR CCDS; CCDS79416.1; -. [Q6NZQ6-2]
DR RefSeq; NP_001276620.1; NM_001289691.1. [Q6NZQ6-2]
DR RefSeq; NP_001276624.1; NM_001289695.1. [Q6NZQ6-1]
DR RefSeq; XP_006521399.1; XM_006521336.2. [Q6NZQ6-2]
DR RefSeq; XP_011244021.1; XM_011245719.1.
DR RefSeq; XP_017172230.1; XM_017316741.1. [Q6NZQ6-1]
DR AlphaFoldDB; Q6NZQ6; -.
DR SMR; Q6NZQ6; -.
DR STRING; 10090.ENSMUSP00000113770; -.
DR iPTMnet; Q6NZQ6; -.
DR PhosphoSitePlus; Q6NZQ6; -.
DR EPD; Q6NZQ6; -.
DR jPOST; Q6NZQ6; -.
DR MaxQB; Q6NZQ6; -.
DR PaxDb; Q6NZQ6; -.
DR PeptideAtlas; Q6NZQ6; -.
DR PRIDE; Q6NZQ6; -.
DR ProteomicsDB; 302143; -. [Q6NZQ6-1]
DR ProteomicsDB; 302144; -. [Q6NZQ6-2]
DR ProteomicsDB; 302145; -. [Q6NZQ6-3]
DR Antibodypedia; 48331; 60 antibodies from 15 providers.
DR DNASU; 68744; -.
DR Ensembl; ENSMUST00000118729; ENSMUSP00000112985; ENSMUSG00000046897. [Q6NZQ6-2]
DR Ensembl; ENSMUST00000119800; ENSMUSP00000113770; ENSMUSG00000046897. [Q6NZQ6-1]
DR GeneID; 68744; -.
DR KEGG; mmu:68744; -.
DR UCSC; uc007xuw.2; mouse. [Q6NZQ6-2]
DR UCSC; uc007xuz.2; mouse. [Q6NZQ6-1]
DR UCSC; uc007xva.2; mouse. [Q6NZQ6-3]
DR CTD; 68744; -.
DR MGI; MGI:1915994; Zfp740.
DR VEuPathDB; HostDB:ENSMUSG00000046897; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000159609; -.
DR HOGENOM; CLU_093195_0_0_1; -.
DR InParanoid; Q6NZQ6; -.
DR OMA; QCERCLQ; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q6NZQ6; -.
DR Reactome; R-MMU-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 68744; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Zfp740; mouse.
DR PRO; PR:Q6NZQ6; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q6NZQ6; protein.
DR Bgee; ENSMUSG00000046897; Expressed in ventricular zone and 253 other tissues.
DR ExpressionAtlas; Q6NZQ6; baseline and differential.
DR Genevisible; Q6NZQ6; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 1.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Isopeptide bond; Metal-binding; Nucleus;
KW Phosphoprotein; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1..180
FT /note="Zinc finger protein 740"
FT /id="PRO_0000251402"
FT ZN_FING 88..110
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 116..138
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 144..166
FT /note="C2H2-type 3; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..62
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 19
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319"
FT CROSSLNK 9
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q8NDX6"
FT VAR_SEQ 1..63
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_020756"
FT VAR_SEQ 29..40
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_020757"
FT VAR_SEQ 64..70
FT /note="SKKTVKK -> MPDCCPQ (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_020758"
FT CONFLICT 8
FT /note="S -> T (in Ref. 1; BAE26025)"
FT /evidence="ECO:0000305"
FT CONFLICT 154
FT /note="S -> P (in Ref. 1; BAE26025)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 180 AA; 20892 MW; DE801DFFC2C98BCE CRC64;
MMLSQIASKQ AENGERAGSP DVLRCSSQMD CKPRFDLSSK GHRKDSDKSR NRKEDDSLAE
ASHSKKTVKK VVVVEQNGSF QVKIPKNFIC EHCFGAFRSS YHLKRHVLIH TGEKPFECDV
CDMRFIQKYH LERHKRVHSG EKPYQCERCH QCFSRTDRLL RHKRMCQGCQ SKTSEGQFSL
