ZN747_HUMAN
ID ZN747_HUMAN Reviewed; 330 AA.
AC Q9BV97; A8K827; B7WNU3; B7Z5R0; Q59FB4; Q96NW0;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-FEB-2022, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Zinc finger protein 747 {ECO:0000312|HGNC:HGNC:28350};
GN Name=ZNF747 {ECO:0000312|HGNC:HGNC:28350};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC TISSUE=Cervix, and Neuroblastoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RA Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.,
RA Ohara O., Nagase T., Kikuno R.F.;
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9BV97; Q92624: APPBP2; NbExp=3; IntAct=EBI-4395497, EBI-743771;
CC Q9BV97; Q0VD86: INCA1; NbExp=3; IntAct=EBI-4395497, EBI-6509505;
CC Q9BV97; Q9UMX1: SUFU; NbExp=5; IntAct=EBI-4395497, EBI-740595;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=3;
CC IsoId=Q9BV97-3; Sequence=Displayed;
CC Name=1;
CC IsoId=Q9BV97-1; Sequence=VSP_061285;
CC Name=2;
CC IsoId=Q9BV97-2; Sequence=VSP_061286;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB70760.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC Sequence=BAD92783.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK054567; BAB70760.1; ALT_SEQ; mRNA.
DR EMBL; AK292192; BAF84881.1; -; mRNA.
DR EMBL; AK299308; BAH12996.1; -; mRNA.
DR EMBL; AB209546; BAD92783.1; ALT_INIT; mRNA.
DR EMBL; AC002310; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471192; EAW52239.1; -; Genomic_DNA.
DR EMBL; BC001361; AAH01361.1; -; mRNA.
DR CCDS; CCDS10682.1; -. [Q9BV97-1]
DR CCDS; CCDS76855.1; -. [Q9BV97-2]
DR CCDS; CCDS76856.1; -. [Q9BV97-3]
DR RefSeq; NP_001291947.1; NM_001305018.1.
DR RefSeq; NP_001291948.1; NM_001305019.1.
DR RefSeq; NP_001291949.1; NM_001305020.1. [Q9BV97-2]
DR RefSeq; NP_076420.1; NM_023931.3. [Q9BV97-1]
DR AlphaFoldDB; Q9BV97; -.
DR SMR; Q9BV97; -.
DR BioGRID; 122437; 42.
DR IntAct; Q9BV97; 5.
DR MINT; Q9BV97; -.
DR STRING; 9606.ENSP00000455659; -.
DR BioMuta; ZNF747; -.
DR DMDM; 74733300; -.
DR MassIVE; Q9BV97; -.
DR PaxDb; Q9BV97; -.
DR PeptideAtlas; Q9BV97; -.
DR PRIDE; Q9BV97; -.
DR ProteomicsDB; 6711; -.
DR ProteomicsDB; 79186; -. [Q9BV97-1]
DR ProteomicsDB; 79187; -. [Q9BV97-2]
DR Antibodypedia; 27341; 79 antibodies from 16 providers.
DR DNASU; 65988; -.
DR Ensembl; ENST00000252799.3; ENSP00000252799.3; ENSG00000169955.8. [Q9BV97-1]
DR Ensembl; ENST00000395094.3; ENSP00000378528.3; ENSG00000169955.8. [Q9BV97-2]
DR Ensembl; ENST00000568028.1; ENSP00000457274.1; ENSG00000169955.8. [Q9BV97-3]
DR GeneID; 65988; -.
DR KEGG; hsa:65988; -.
DR UCSC; uc002dyn.4; human. [Q9BV97-3]
DR UCSC; uc059tfh.1; human.
DR CTD; 65988; -.
DR GeneCards; ENSG00000261459; -.
DR GeneCards; ZNF747; -.
DR HGNC; HGNC:28350; ZNF747.
DR HPA; ENSG00000169955; Low tissue specificity.
DR neXtProt; NX_Q9BV97; -.
DR OpenTargets; ENSG00000169955; -.
DR PharmGKB; PA144596521; -.
DR VEuPathDB; HostDB:ENSG00000169955; -.
DR VEuPathDB; HostDB:ENSG00000261459; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000160032; -.
DR HOGENOM; CLU_002678_13_2_1; -.
DR InParanoid; Q9BV97; -.
DR OMA; VYSHRGE; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9BV97; -.
DR TreeFam; TF337922; -.
DR TreeFam; TF341914; -.
DR PathwayCommons; Q9BV97; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q9BV97; -.
DR BioGRID-ORCS; 65988; 16 hits in 1083 CRISPR screens.
DR GenomeRNAi; 65988; -.
DR Pharos; Q9BV97; Tdark.
DR PRO; PR:Q9BV97; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q9BV97; protein.
DR Bgee; ENSG00000169955; Expressed in olfactory bulb and 171 other tissues.
DR ExpressionAtlas; Q9BV97; baseline and differential.
DR Genevisible; Q9BV97; HS.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 1: Evidence at protein level;
KW Alternative splicing; Metal-binding; Reference proteome; Repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..330
FT /note="Zinc finger protein 747"
FT /id="PRO_0000293691"
FT DOMAIN 37..108
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 181..203
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 209..231
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 237..259
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 265..287
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 99..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..130
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 78..329
FT /note="VGGSKPALISWVEEKAELWDPAAQDPEVAKCPTEADPDSRNKEEERQREGTG
FT ALEKPDPVAAGSPGLKAPQAPFAGLEQLSKARRRSRPRFFAHPPVPRADQRHGCYVCGK
FT SFAWRSTLVEHIYSHRGEKPFHCADCGKGFGHASSLSKHRAIHRGERPHRCPECGRAFM
FT RRTALTSHLRVHTGEKPYRCPQCGRCFGLKTGMAKHQWVHRPGGEGRRGRRPGGLSVTL
FT TPVRGDLDPPVGFQLYPEIFQEC -> ESPTCLPGPCASTGPAAPLGAACGVGGPGAGQ
FT AASSQRGVCVLLPQESEAASRRSSPGWRRRPNCGIRLPRIRRWRSVRQKRTQQIPETRK
FT RKDKGKGREPWRSPTLWPPGLL (in isoform 1)"
FT /id="VSP_061285"
FT VAR_SEQ 78..329
FT /note="VGGSKPALISWVEEKAELWDPAAQDPEVAKCPTEADPDSRNKEEERQREGTG
FT ALEKPDPVAAGSPGLKAPQAPFAGLEQLSKARRRSRPRFFAHPPVPRADQRHGCYVCGK
FT SFAWRSTLVEHIYSHRGEKPFHCADCGKGFGHASSLSKHRAIHRGERPHRCPECGRAFM
FT RRTALTSHLRVHTGEKPYRCPQCGRCFGLKTGMAKHQWVHRPGGEGRRGRRPGGLSVTL
FT TPVRGDLDPPVGFQLYPEIFQEC -> ESPTCLPGPCASTGPAAPLGAACGVGGPGAGQ
FT AASSQRGVCVLLPQESEAASRRSSPGWRRRPNCGIRLPRIRRWRSVRQKRTQIPETRKR
FT KDKGKGREPWRSPTLWPPGLL (in isoform 2)"
FT /id="VSP_061286"
FT CONFLICT 27
FT /note="A -> V (in Ref. 1; BAB70760)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 330 AA; 36399 MW; AD9C9CF3844E08AD CRC64;
MTDPSLGLTV PMAPPLAPLP PRDPNGAGSE WRKPGAVSFA DVAVYFSREE WGCLRPAQRA
LYRDVMRETY GHLGALGVGG SKPALISWVE EKAELWDPAA QDPEVAKCPT EADPDSRNKE
EERQREGTGA LEKPDPVAAG SPGLKAPQAP FAGLEQLSKA RRRSRPRFFA HPPVPRADQR
HGCYVCGKSF AWRSTLVEHI YSHRGEKPFH CADCGKGFGH ASSLSKHRAI HRGERPHRCP
ECGRAFMRRT ALTSHLRVHT GEKPYRCPQC GRCFGLKTGM AKHQWVHRPG GEGRRGRRPG
GLSVTLTPVR GDLDPPVGFQ LYPEIFQECG
