ID   ZN750_BOVIN             Reviewed;         703 AA.
AC   A2VDR9;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Zinc finger protein 750;
GN   Name=ZNF750;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor involved in epidermis differentiation.
CC       Required for terminal epidermal differentiation: acts downstream of
CC       p63/TP63 and activates expression of late epidermal differentiation
CC       genes. Specifically binds to the promoter of KLF4 and promotes its
CC       expression (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; BC133373; AAI33374.1; -; mRNA.
DR   RefSeq; NP_001075002.1; NM_001081533.1.
DR   AlphaFoldDB; A2VDR9; -.
DR   SMR; A2VDR9; -.
DR   STRING; 9913.ENSBTAP00000034629; -.
DR   PaxDb; A2VDR9; -.
DR   PRIDE; A2VDR9; -.
DR   Ensembl; ENSBTAT00000034744; ENSBTAP00000034629; ENSBTAG00000015406.
DR   GeneID; 535628; -.
DR   KEGG; bta:535628; -.
DR   CTD; 79755; -.
DR   VEuPathDB; HostDB:ENSBTAG00000015406; -.
DR   VGNC; VGNC:37340; ZNF750.
DR   eggNOG; ENOG502QU7X; Eukaryota.
DR   GeneTree; ENSGT00530000063870; -.
DR   HOGENOM; CLU_023455_0_0_1; -.
DR   InParanoid; A2VDR9; -.
DR   OMA; FFQQYPS; -.
DR   OrthoDB; 298573at2759; -.
DR   TreeFam; TF331381; -.
DR   Reactome; R-BTA-212436; Generic Transcription Pathway.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000015406; Expressed in esophagus and 68 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISS:UniProtKB.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:1990841; F:promoter-specific chromatin binding; ISS:UniProtKB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0008544; P:epidermis development; ISS:UniProtKB.
DR   GO; GO:0010719; P:negative regulation of epithelial to mesenchymal transition; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   InterPro; IPR039363; ZNF750.
DR   InterPro; IPR039064; ZNF750_Znf.
DR   PANTHER; PTHR14678; PTHR14678; 1.
DR   Pfam; PF15269; zf-C2H2_7; 1.
PE   2: Evidence at transcript level;
KW   Activator; Differentiation; Metal-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..703
FT                   /note="Zinc finger protein 750"
FT                   /id="PRO_0000284952"
FT   ZN_FING         25..46
FT                   /note="C2H2-type; degenerate"
FT   REGION          60..96
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          121..147
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          362..617
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          633..703
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        60..93
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        369..399
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        413..431
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        470..498
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        571..585
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   703 AA;  75167 MW;  621465798EB98152 CRC64;
     MSLLKERKPK KPHYIPRPPG KPFKYKCFQC PFTCNEKSHL FNHMKYGLCK NSITLVSEQD
     RVPKCSKPNS SDPKQTNQPD PVVKPTSSKP VPSGLSHLDA KLQHSLAKDD IKENLDLHAR
     GPHRCLGQKP TPHKEAAPPS PAPEAAVGTQ PVLEGAVRPS AFVPVGEHRL KGQELTETPE
     ALALTHAPAK ASSFHTKSAF HAPGYPWRAG SPFLTPEFPH KIPSTKGFGA TSPYVHPSIT
     EYPPHFYTEH GLATIYSPYL LAGNSPECDS PLLSVYGAQD QRHFLPHPGP IPKHLNPAPS
     TYDHYRFFQQ YHSSLPIPYG FYRPESAFSS YGLRLPPVAG ISRDQSSHLL EEAALGYQAL
     SPSKLNSSNS HKKHTELEKQ SPTPEAKEPS KDGQRDTEGT KMSPRAGSAA TGSPGRPSPT
     NFTQTSQPCA GLCGLSDAPA SSAPGRIPPP EQGLAAFKPI KKNTEHPHSQ APENRAVSPK
     SLEALSTDAP TQLGSLEAAP SSPEDGSRAA PLNLSTKPEA EPAATCSPAH GGFVEPQDAP
     LNLSVKDPCN ALTSRPSVCS PPRGAEPAAA PTPSPTQQRE PASSGDGPDP SSVEAPVPSP
     TGKAQDIRAA DSDEQKQTAA VALCQLAAYS PGNVEPAAQE PTCRPDAPTP RAPESQEAQC
     DLRPKGQKRT SPREVGKGQQ GSKKAKPSDT ARVFTLRKRT RVS