ZN750_DANRE
ID ZN750_DANRE Reviewed; 607 AA.
AC Q568E2; F1R5I0;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2012, sequence version 2.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=Zinc finger protein 750;
GN Name=znf750; ORFNames=zgc:110351;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription factor involved in epidermis differentiation.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; BX248236; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC092893; AAH92893.1; -; mRNA.
DR RefSeq; NP_001017786.1; NM_001017786.1.
DR RefSeq; XP_017209672.1; XM_017354183.1.
DR AlphaFoldDB; Q568E2; -.
DR STRING; 7955.ENSDARP00000058642; -.
DR PaxDb; Q568E2; -.
DR Ensembl; ENSDART00000160717; ENSDARP00000131237; ENSDARG00000102267.
DR GeneID; 550483; -.
DR KEGG; dre:550483; -.
DR CTD; 79755; -.
DR ZFIN; ZDB-GENE-050417-313; znf750.
DR eggNOG; ENOG502QU7X; Eukaryota.
DR GeneTree; ENSGT00530000063870; -.
DR HOGENOM; CLU_041875_0_0_1; -.
DR InParanoid; Q568E2; -.
DR OMA; FFQQYPS; -.
DR OrthoDB; 298573at2759; -.
DR TreeFam; TF331381; -.
DR Reactome; R-DRE-212436; Generic Transcription Pathway.
DR PRO; PR:Q568E2; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 3.
DR Bgee; ENSDARG00000102267; Expressed in zone of skin and 6 other tissues.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:1990841; F:promoter-specific chromatin binding; ISS:UniProtKB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0008544; P:epidermis development; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR InterPro; IPR039363; ZNF750.
DR InterPro; IPR039064; ZNF750_Znf.
DR PANTHER; PTHR14678; PTHR14678; 1.
DR Pfam; PF15269; zf-C2H2_7; 1.
PE 2: Evidence at transcript level;
KW Activator; Differentiation; Metal-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..607
FT /note="Zinc finger protein 750"
FT /id="PRO_0000247072"
FT ZN_FING 25..46
FT /note="C2H2-type; degenerate"
FT REGION 60..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 318..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 482..511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 575..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..78
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..133
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..334
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..416
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..464
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..607
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 452
FT /note="H -> L (in Ref. 2; AAH92893)"
FT /evidence="ECO:0000305"
FT CONFLICT 517
FT /note="Q -> R (in Ref. 2; AAH92893)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 607 AA; 68135 MW; AE8293A0C153AA43 CRC64;
METLQGRKPK KPHYIPRPPG KPFKYQCFQC PFTCNIKSHL FNHMKYNLCK NSISLVSQRM
EQTGKASRAS QHSPAFSHNS KELPLDAEST KPIENVKIEK AVTKEAREKP QSPIKEVSKD
DTEPALEAKD KSEDMDIAQN KISSAFSPVA RTCESEALSL SPHKDDQSTI PHFYQQIAPW
VTSASSAHLL PPIPEYPPYM VPERSLPPLY APYPHNQAST PAYQVTPRET QRPLVPSPLI
PPNSSLLHPY HYRYGHSIFP SPPLPYSFYQ HPELSIPLQR SRYLPLDVYS SRFYPREYGG
HLVPLTHPES YSRLAEDRAV QEHNTGDKGI RESPLEGCDA SGSPDRPSTA DVTQRIPVGL
RLASHGESHS GSQSHIISGS TKANDNLPKM PCGQNQEKML QKTERYDSQT TISSRSSDIS
DKEEDEETEE EIGPLNLSKR DQATSNNMTH HHYPDRELHY DSESSQEEAP LNLCLRVQSS
NQALPNTSET PEKETISNAE VSTTESPQDL EPCDQRQTAA FALCQLASSR DIINDTSVKQ
QDVTESQNTK CLPSPDNCSV KDSPNILNAS MVALGQKRAN NRPLRHTNKR AKVKEPSRPR
RKRSQNC
