ZN750_MOUSE
ID ZN750_MOUSE Reviewed; 703 AA.
AC Q8BH05; B1ATU1; B9EKG8; Q66JP3; Q8C0L1;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Zinc finger protein 750;
GN Name=Znf750; Synonyms=Zfp750;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head, and Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Transcription factor involved in epidermis differentiation.
CC Required for terminal epidermal differentiation: acts downstream of
CC p63/TP63 and activates expression of late epidermal differentiation
CC genes. Specifically binds to the promoter of KLF4 and promotes its
CC expression (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; AK030690; BAC27080.1; -; mRNA.
DR EMBL; AK037185; BAC29743.1; -; mRNA.
DR EMBL; AK037240; BAC29771.1; -; mRNA.
DR EMBL; AL663088; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC150905; AAI50906.1; -; mRNA.
DR CCDS; CCDS25779.1; -.
DR RefSeq; NP_848878.1; NM_178763.4.
DR AlphaFoldDB; Q8BH05; -.
DR STRING; 10090.ENSMUSP00000089951; -.
DR PhosphoSitePlus; Q8BH05; -.
DR PaxDb; Q8BH05; -.
DR PRIDE; Q8BH05; -.
DR ProteomicsDB; 275035; -.
DR Antibodypedia; 19924; 118 antibodies from 27 providers.
DR DNASU; 319530; -.
DR Ensembl; ENSMUST00000092298; ENSMUSP00000089951; ENSMUSG00000039238.
DR GeneID; 319530; -.
DR KEGG; mmu:319530; -.
DR UCSC; uc007mvz.2; mouse.
DR CTD; 319530; -.
DR MGI; MGI:2442210; Zfp750.
DR VEuPathDB; HostDB:ENSMUSG00000039238; -.
DR eggNOG; ENOG502QU7X; Eukaryota.
DR GeneTree; ENSGT00530000063870; -.
DR HOGENOM; CLU_023455_0_0_1; -.
DR InParanoid; Q8BH05; -.
DR OMA; FFQQYPS; -.
DR OrthoDB; 79003at2759; -.
DR PhylomeDB; Q8BH05; -.
DR TreeFam; TF331381; -.
DR Reactome; R-MMU-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 319530; 3 hits in 73 CRISPR screens.
DR PRO; PR:Q8BH05; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8BH05; protein.
DR Bgee; ENSMUSG00000039238; Expressed in animal zygote and 86 other tissues.
DR Genevisible; Q8BH05; MM.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISS:UniProtKB.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:1990841; F:promoter-specific chromatin binding; ISS:UniProtKB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0008544; P:epidermis development; ISS:UniProtKB.
DR GO; GO:0010719; P:negative regulation of epithelial to mesenchymal transition; ISO:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR InterPro; IPR039363; ZNF750.
DR InterPro; IPR039064; ZNF750_Znf.
DR PANTHER; PTHR14678; PTHR14678; 1.
DR Pfam; PF15269; zf-C2H2_7; 1.
PE 2: Evidence at transcript level;
KW Activator; Differentiation; Metal-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..703
FT /note="Zinc finger protein 750"
FT /id="PRO_0000247071"
FT ZN_FING 25..46
FT /note="C2H2-type; degenerate"
FT REGION 64..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 350..527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 553..614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 630..703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 361..394
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..498
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..609
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 641..655
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 131
FT /note="L -> Q (in Ref. 1; BAC27080)"
FT /evidence="ECO:0000305"
FT CONFLICT 421
FT /note="F -> L (in Ref. 1; BAC27080)"
FT /evidence="ECO:0000305"
FT CONFLICT 638
FT /note="V -> A (in Ref. 3; AAI50906)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 703 AA; 76645 MW; 5C93367C6595BD8A CRC64;
MSLLKERKPK KPHYIPRPPG KPFKYKCFQC PFTCNEKSHL FNHMKYGLCK NSITLVSEQD
RIPKCPKSSS LDPKQTHQPE PTSKPATSKS LLNGLSSFDP KSQQGSAKED AKENLEMQAR
GAHKGPQKPA LQKEMAPEAI LSTQPCLDSG VRHSAFVPVG EHRLRGPEDT EATEVLANST
TKASSFHAKS AFHTPGYPWK AGSPFLPPDF PHKISSTKGF GAISPYMHPA IPEYPHPFYA
EHGLAAIYSP YLLTGNTPEC ETTLLSVYGT QDQRHFLSPA GPIPKHLNTS PSTYDHYRFF
QQYHSNLPIP YGFYRPESAF PSYSLRLPSV TGITRDQSSR LLEDATLAYP ASSPSELNLS
SSHRKHTECE KGSPVPEAKD PSKDGQRDAE EAKMSPRAGS AATGSPGRPS PTNFTQTSQT
FEGLCDLSNK AASSGTLERL QQAEQSPTAF KPVQRGSESP HSQPPANRTE SPKSLQAMNG
DPPAQTGSSN SFITEAPPSS PEDHSRIGPL NLSKKLETNP AATYGPMYAS NAQADTLQDL
PLNLSVKDLC NAWAPRPALP GPPQGAEPAA TPKTETKGSE DRTSRVETPQ DKAHSRTTPD
VHTEDSSDEQ KQTAAVALCQ LAAYSPGNVR VADEEGTVQE PTRQDVPTLS ATENLEAQCD
LRPKGQKRTS QRDTGKSQQG TKKPKLNDPV PRVLTLRRRT RVS
