ID   ZN750_XENLA             Reviewed;         674 AA.
AC   Q32N19; Q7ZYL3;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Zinc finger protein 750;
GN   Name=znf750;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor involved in epidermis differentiation.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC043737; AAH43737.1; -; mRNA.
DR   EMBL; BC108879; AAI08880.1; -; mRNA.
DR   RefSeq; NP_001079466.1; NM_001085997.1.
DR   AlphaFoldDB; Q32N19; -.
DR   DNASU; 379153; -.
DR   GeneID; 379153; -.
DR   KEGG; xla:379153; -.
DR   CTD; 379153; -.
DR   Xenbase; XB-GENE-5775750; znf750.L.
DR   OMA; PINAPFE; -.
DR   OrthoDB; 298573at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 379153; Expressed in zone of skin and 9 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISS:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:1990841; F:promoter-specific chromatin binding; ISS:UniProtKB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0008544; P:epidermis development; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   InterPro; IPR039363; ZNF750.
DR   InterPro; IPR039064; ZNF750_Znf.
DR   PANTHER; PTHR14678; PTHR14678; 1.
DR   Pfam; PF15269; zf-C2H2_7; 1.
PE   2: Evidence at transcript level;
KW   Activator; Differentiation; Metal-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..674
FT                   /note="Zinc finger protein 750"
FT                   /id="PRO_0000247073"
FT   ZN_FING         25..46
FT                   /note="C2H2-type; degenerate"
FT   REGION          105..125
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          370..466
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          594..674
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        105..124
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        396..431
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        439..466
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        644..659
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        74
FT                   /note="N -> K (in Ref. 1; AAH43737)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   674 AA;  74646 MW;  E981AA59B84E7A34 CRC64;
     MSLMKERKPK KPHYIPRPPG KPFKYKCFQC PFTCNEKSHL FNHMKYGLCK NSITVVTDQD
     RIIKNPKVNS MDQNQTSNEP FAKSSVPAIN SSLESKMLHS VAREEAKENL DLKNEPKSHA
     EKTTVSKEFT LSPPVAISQI NKPPSLDGVM RPSAFIPVGE HRVKKGAENR TIPELTSISA
     EPAKGVHSIK SAFHSLPTPW KSGLVSPDFS QKSSIPRYIR PMISEYPPQF YSEAGLPAVF
     SPYLFPQTEC ENPMLSIYST PDQRPYLPHP LQPSGLPLPK PINAPFEHYR LLQQFQQNPQ
     LHYGFYRPTE HPYFSYGLKV PPAPGLSKEH TSQSMDSPTF IYPSSHPSRL YPLEGFQKLF
     EIQKETPPVL AKNLDSKSDS ESVKMSPRAG SAATGSPERP SPTNFTQSSQ GHEGIFDLST
     KSISTSDKIG KDFTSGKAMR KSTDSQTIIS RENSPSFGND GVQSHSEGIT VTDDAVHDDT
     IAPLNLSKKS EVESRDIVDT VNNSDFTNER VGFMEMQDLP LNLSVKDSGS NHNTLCADER
     VLLPRQSTSP PVYQAIQTTD NRAPTTTGIH SLGIIENCDE QKQSAAVALC QLATSSPGVP
     PRGTEDEFPE KETVVPEQVQ PRSPAAQETE TDVGARGQKR TNSKELGKSQ SSTKKQKAVD
     SGRMFTLRKR PRVS