ID   ZN750_XENTR             Reviewed;         671 AA.
AC   Q28BT7; Q6DIF8;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 2.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Zinc finger protein 750;
GN   Name=znf750; ORFNames=TNeu069m12.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor involved in epidermis differentiation.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; CR942644; CAJ82741.1; -; mRNA.
DR   EMBL; BC075584; AAH75584.1; -; mRNA.
DR   RefSeq; NP_001004995.1; NM_001004995.1.
DR   AlphaFoldDB; Q28BT7; -.
DR   SMR; Q28BT7; -.
DR   STRING; 8364.ENSXETP00000044280; -.
DR   PaxDb; Q28BT7; -.
DR   DNASU; 448470; -.
DR   GeneID; 448470; -.
DR   KEGG; xtr:448470; -.
DR   CTD; 79755; -.
DR   Xenbase; XB-GENE-5775684; znf750.
DR   eggNOG; ENOG502QU7X; Eukaryota.
DR   HOGENOM; CLU_023455_0_0_1; -.
DR   InParanoid; Q28BT7; -.
DR   OrthoDB; 298573at2759; -.
DR   PhylomeDB; Q28BT7; -.
DR   TreeFam; TF331381; -.
DR   Reactome; R-XTR-212436; Generic Transcription Pathway.
DR   Proteomes; UP000008143; Chromosome 10.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000020479; Expressed in gastrula and 7 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISS:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:1990841; F:promoter-specific chromatin binding; ISS:UniProtKB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0008544; P:epidermis development; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   InterPro; IPR039363; ZNF750.
DR   InterPro; IPR039064; ZNF750_Znf.
DR   PANTHER; PTHR14678; PTHR14678; 1.
DR   Pfam; PF15269; zf-C2H2_7; 1.
PE   2: Evidence at transcript level;
KW   Activator; Differentiation; Metal-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..671
FT                   /note="Zinc finger protein 750"
FT                   /id="PRO_0000247074"
FT   ZN_FING         25..46
FT                   /note="C2H2-type; degenerate"
FT   REGION          66..87
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          366..433
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          592..671
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        66..80
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        397..430
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        630..664
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        513
FT                   /note="I -> M (in Ref. 1; CAJ82741)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   671 AA;  74240 MW;  C5684C51BB9D0BAF CRC64;
     MSLVKERKPK KPHYIPRPPG KPFKYKCFQC PFTCNEKSHL FNHMKYGLCK NSITVVTDQD
     RIVKNPKVNS TDQKQPSNEP FAKSPVPAIN GLTGLESKTQ HSVAREEAKE NFDLKNEAKP
     HVEKTTVTKE VTLPPTAIIG QINKPPSLDG VMRPSAFIPV GEHRLKGTEN IKIPELSSVS
     TEPAKGVHSI KSAFHSLPTP WKSGLVSPDF SHKSSIPRYI RPMISEYPPQ FYSETGLPAV
     FSPYLFPQAE CENPMLSVYS APEQRPFLPH PLQASGLPLP KPINAPFEHY RLLQQFQQNP
     QLHYGFYRPT EHPYFSYGLK VPPVPSLSKE HTSQSVDSPT FIYPSSHPSR LYPLEGFQKL
     AEIQKETSPV PAKNLDSKSD SESVKMSPRA GSAATGSPGR PSPTNFTQNS QGHEGIFDLS
     TKSTSDKAGK DFTSGKAVRK STDCQTTISR EHSPCFRNDE IQSHSDCYSD DAAPHDSVAP
     LNLSKRPEVE DRAVFDTMHN SDSNDESVGF MEIQDLPLNL SVKDSGNNQK ALCADERLLL
     PRQVTSSPNY HFIHTVDKRV PATTGVHSLG IIENCDEQKQ SAAVALCQLA TSSPGVPARG
     TEDEFSEKET VAPEQVHPRA PAAQETEADI GARGQKRTNS KEPGKSQSSN KKHKSVDSGR
     MFTLRKRPRV S