ZN75A_HUMAN
ID ZN75A_HUMAN Reviewed; 296 AA.
AC Q96N20; Q0VDI8; Q92669;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Zinc finger protein 75A;
GN Name=ZNF75A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 202-291.
RC TISSUE=Peripheral blood;
RX PubMed=8661144; DOI=10.1006/geno.1996.0362;
RA Villa A., Strina D., Frattini A., Faranda S., Macchi P., Finelli P.,
RA Bozzi F., Susani L., Archidiacono N., Rocchi M., Vezzoni P.;
RT "The ZNF75 zinc finger gene subfamily: isolation and mapping of the four
RT members in humans and great apes.";
RL Genomics 35:312-320(1996).
RN [4]
RP VARIANT [LARGE SCALE ANALYSIS] GLU-228.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q96N20; Q5MJ10: SPANXN2; NbExp=3; IntAct=EBI-21734356, EBI-12023934;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK056091; BAB71092.1; -; mRNA.
DR EMBL; BC119652; AAI19653.1; -; mRNA.
DR EMBL; BC119653; AAI19654.1; -; mRNA.
DR EMBL; X91826; CAA62935.1; -; Genomic_DNA.
DR CCDS; CCDS10501.1; -.
DR RefSeq; NP_001289038.1; NM_001302109.1.
DR RefSeq; NP_694573.1; NM_153028.3.
DR RefSeq; XP_011520949.1; XM_011522647.2.
DR RefSeq; XP_016879131.1; XM_017023642.1.
DR AlphaFoldDB; Q96N20; -.
DR SMR; Q96N20; -.
DR BioGRID; 113446; 8.
DR IntAct; Q96N20; 2.
DR STRING; 9606.ENSP00000459566; -.
DR iPTMnet; Q96N20; -.
DR PhosphoSitePlus; Q96N20; -.
DR BioMuta; ZNF75A; -.
DR DMDM; 68566224; -.
DR MassIVE; Q96N20; -.
DR PaxDb; Q96N20; -.
DR PeptideAtlas; Q96N20; -.
DR PRIDE; Q96N20; -.
DR Antibodypedia; 816; 130 antibodies from 18 providers.
DR DNASU; 7627; -.
DR Ensembl; ENST00000574298.6; ENSP00000459566.1; ENSG00000162086.16.
DR Ensembl; ENST00000617839.1; ENSP00000482769.1; ENSG00000162086.16.
DR GeneID; 7627; -.
DR KEGG; hsa:7627; -.
DR UCSC; uc002cut.5; human.
DR CTD; 7627; -.
DR DisGeNET; 7627; -.
DR GeneCards; ZNF75A; -.
DR HGNC; HGNC:13146; ZNF75A.
DR HPA; ENSG00000162086; Low tissue specificity.
DR MIM; 601473; gene.
DR neXtProt; NX_Q96N20; -.
DR OpenTargets; ENSG00000162086; -.
DR PharmGKB; PA37720; -.
DR VEuPathDB; HostDB:ENSG00000162086; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162456; -.
DR HOGENOM; CLU_002678_0_7_1; -.
DR InParanoid; Q96N20; -.
DR OMA; IRALWEC; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q96N20; -.
DR TreeFam; TF340832; -.
DR PathwayCommons; Q96N20; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q96N20; -.
DR BioGRID-ORCS; 7627; 10 hits in 1094 CRISPR screens.
DR ChiTaRS; ZNF75A; human.
DR GenomeRNAi; 7627; -.
DR Pharos; Q96N20; Tdark.
DR PRO; PR:Q96N20; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q96N20; protein.
DR Bgee; ENSG00000162086; Expressed in oviduct epithelium and 186 other tissues.
DR ExpressionAtlas; Q96N20; baseline and differential.
DR Genevisible; Q96N20; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..296
FT /note="Zinc finger protein 75A"
FT /id="PRO_0000047385"
FT DOMAIN 1..66
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 161..183
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 189..211
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 217..239
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 245..267
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 273..295
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 84
FT /note="V -> A (in dbSNP:rs17611866)"
FT /id="VAR_033545"
FT VARIANT 228
FT /note="Q -> E (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035570"
SQ SEQUENCE 296 AA; 34694 MW; D8EBD7023CA726AA CRC64;
MYFSQEEWEL LDPTQKALYN DVMQENYETV ISLALFVLPK PKVISCLEQG EEPWVQVSPE
FKDSAGKSPT GLKLKNDTEN HQPVSLSDLE IQASAGVISK KAKVKVPQKT AGKENHFDMH
RVGKWHQDFP VKKRKKLSTW KQELLKLMDR HKKDCAREKP FKCQECGKTF RVSSDLIKHQ
RIHTEEKPYK CQQCDKRFRW SSDLNKHLTT HQGIKPYKCS WCGKSFSQNT NLHTHQRTHT
GEKPFTCHEC GKKFSQNSHL IKHRRTHTGE QPYTCSICRR NFSRRSSLLR HQKLHL