ZN75C_HUMAN
ID ZN75C_HUMAN Reviewed; 426 AA.
AC Q92670;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 2.
DT 25-MAY-2022, entry version 137.
DE RecName: Full=Putative zinc finger protein 75C;
DE AltName: Full=Zinc finger protein 75C pseudogene;
GN Name=ZNF75CP; Synonyms=ZNF75C;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 333-422.
RC TISSUE=Peripheral blood;
RX PubMed=8661144; DOI=10.1006/geno.1996.0362;
RA Villa A., Strina D., Frattini A., Faranda S., Macchi P., Finelli P.,
RA Bozzi F., Susani L., Archidiacono N., Rocchi M., Vezzoni P.;
RT "The ZNF75 zinc finger gene subfamily: isolation and mapping of the four
RT members in humans and great apes.";
RL Genomics 35:312-320(1996).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; AP003086; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; X91828; CAA62937.1; -; Genomic_DNA.
DR AlphaFoldDB; Q92670; -.
DR SMR; Q92670; -.
DR iPTMnet; Q92670; -.
DR PhosphoSitePlus; Q92670; -.
DR BioMuta; HGNC:13148; -.
DR DMDM; 205831223; -.
DR jPOST; Q92670; -.
DR MassIVE; Q92670; -.
DR PeptideAtlas; Q92670; -.
DR PRIDE; Q92670; -.
DR ProteomicsDB; 75401; -.
DR GeneCards; ZNF75CP; -.
DR HGNC; HGNC:13148; ZNF75CP.
DR neXtProt; NX_Q92670; -.
DR InParanoid; Q92670; -.
DR PhylomeDB; Q92670; -.
DR PathwayCommons; Q92670; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR Pharos; Q92670; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q92670; protein.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR CDD; cd07936; SCAN; 1.
DR Gene3D; 1.10.4020.10; -; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR038269; SCAN_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF02023; SCAN; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00431; SCAN; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 5: Uncertain;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..426
FT /note="Putative zinc finger protein 75C"
FT /id="PRO_0000349242"
FT DOMAIN 49..131
FT /note="SCAN box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00187"
FT DOMAIN 205..289
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 292..314
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 320..342
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 348..370
FT /note="C2H2-type 3; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 376..398
FT /note="C2H2-type 4; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 404..426
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CONFLICT 394
FT /note="Y -> H (in Ref. 2; CAA62937)"
FT /evidence="ECO:0000305"
FT CONFLICT 408..410
FT /note="ICR -> LCK (in Ref. 2; CAA62937)"
FT /evidence="ECO:0000305"
FT CONFLICT 416..417
FT /note="QL -> RS (in Ref. 2; CAA62937)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 426 AA; 49753 MW; F88B9E97A42FA06B CRC64;
MIMRELKADA CLNSHMGAMW ETNRSVKENS SQSKKYSTQI ECLSPGSACR HFRSFHYHEA
TEPLEAINQL QKLCHQWLRP EIHSKKHILE MLVLEHFLTI LPKGTQNWVQ KHHPQLAKQA
LVLVERLQRE PGGTKNEVTA HELGEEAVLL RGTTVAPGFK WKPAELEPME RILEHIQILA
LSEHKSTKDW KMAPKLIWPE SQSLLTFEDM AVYFSEEEWQ LLGPLEKTLY NDVMQDIYET
AISLGKQRTG KIMGIEMASS FSKEEKKLTT CKQELPKLMD LHGKGHTGEK PFKCQDCGKI
FRVSSDLIKH QRIHTEEKLY KCQQCDRRFR WSSGLNKHFM THQGINPYRC SWYGKSISYD
TNLQTHQRIH TGEKPFKCHE CGKIFIHKSN LIKYQRTHTG EQPYTCSICR RNFSRQLSLL
RHQKLH
