ZN75D_HUMAN
ID ZN75D_HUMAN Reviewed; 510 AA.
AC P51815; A6NK62; B3KRI7; Q5JPG0; Q6LDE0;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 190.
DE RecName: Full=Zinc finger protein 75D;
DE AltName: Full=Zinc finger protein 75;
DE AltName: Full=Zinc finger protein 82;
GN Name=ZNF75D; Synonyms=ZNF75, ZNF82;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, and Thalamus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Lymph node;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 222-510.
RC TISSUE=Lung fibroblast;
RX PubMed=8288223; DOI=10.1006/geno.1993.1459;
RA Villa A., Zucchi I., Pilia G., Strina D., Susani L., Morali F.,
RA Patrosso C., Frattini A., Lucchini F., Repetto M., Sacco M.G., Zoppe M.,
RA Vezzoni P.;
RT "ZNF75: isolation of a cDNA clone of the KRAB zinc finger gene subfamily
RT mapped in YACs 1 Mb telomeric of HPRT.";
RL Genomics 18:223-229(1993).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 292-510.
RX PubMed=1505955; DOI=10.1016/0888-7543(92)90040-y;
RA Villa A., Patrosso C., Biunno I., Frattini A., Repetto M., Mostardini M.,
RA Evans G., Susani L., Strina D., Redolfi E., Lazzari B., Pellegrini M.,
RA Vezzoni P.;
RT "Isolation of a zinc finger motif (ZNF75) mapping on chromosome Xq26.";
RL Genomics 13:1231-1236(1992).
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 360-510.
RA Marino M., Archidiacono N., Franze N., Rosati M., Rocchi M., Ballabio A.,
RA Grimaldi G.;
RT "The human zinc finger gene family: isolation, mapping and expression of
RT two X-linked members.";
RL Submitted (AUG-1994) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P51815-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P51815-2; Sequence=VSP_044460;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK091687; BAG52399.1; -; mRNA.
DR EMBL; AK290215; BAF82904.1; -; mRNA.
DR EMBL; AL832801; CAI46130.1; -; mRNA.
DR EMBL; AL450472; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL590282; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC109100; AAI09101.1; -; mRNA.
DR EMBL; S67970; AAB29696.1; -; mRNA.
DR EMBL; S43109; AAB22971.1; -; Genomic_DNA.
DR EMBL; X68010; CAA48147.1; -; Genomic_DNA.
DR CCDS; CCDS14648.1; -. [P51815-1]
DR CCDS; CCDS55503.1; -. [P51815-2]
DR PIR; A48913; A48913.
DR RefSeq; NP_001171992.1; NM_001185063.2. [P51815-2]
DR RefSeq; NP_009062.2; NM_007131.4. [P51815-1]
DR RefSeq; XP_005262526.1; XM_005262469.1.
DR RefSeq; XP_011529693.1; XM_011531391.1.
DR AlphaFoldDB; P51815; -.
DR SMR; P51815; -.
DR IntAct; P51815; 2.
DR STRING; 9606.ENSP00000359802; -.
DR iPTMnet; P51815; -.
DR PhosphoSitePlus; P51815; -.
DR BioMuta; ZNF75D; -.
DR DMDM; 212276486; -.
DR jPOST; P51815; -.
DR MassIVE; P51815; -.
DR PaxDb; P51815; -.
DR PeptideAtlas; P51815; -.
DR PRIDE; P51815; -.
DR ProteomicsDB; 1382; -.
DR ProteomicsDB; 56418; -. [P51815-1]
DR Antibodypedia; 846; 117 antibodies from 26 providers.
DR DNASU; 7626; -.
DR Ensembl; ENST00000370764.1; ENSP00000359800.1; ENSG00000186376.15. [P51815-2]
DR Ensembl; ENST00000370766.8; ENSP00000359802.3; ENSG00000186376.15. [P51815-1]
DR GeneID; 7626; -.
DR KEGG; hsa:7626; -.
DR MANE-Select; ENST00000370766.8; ENSP00000359802.3; NM_007131.5; NP_009062.2.
DR UCSC; uc004eyo.5; human. [P51815-1]
DR CTD; 7626; -.
DR GeneCards; ZNF75D; -.
DR HGNC; HGNC:13145; ZNF75D.
DR HPA; ENSG00000186376; Low tissue specificity.
DR MIM; 314997; gene.
DR neXtProt; NX_P51815; -.
DR OpenTargets; ENSG00000186376; -.
DR PharmGKB; PA37719; -.
DR VEuPathDB; HostDB:ENSG00000186376; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162817; -.
DR HOGENOM; CLU_002678_49_4_1; -.
DR InParanoid; P51815; -.
DR OMA; MFQKECW; -.
DR PhylomeDB; P51815; -.
DR TreeFam; TF341729; -.
DR PathwayCommons; P51815; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; P51815; -.
DR BioGRID-ORCS; 7626; 4 hits in 726 CRISPR screens.
DR ChiTaRS; ZNF75D; human.
DR GenomeRNAi; 7626; -.
DR Pharos; P51815; Tdark.
DR PRO; PR:P51815; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; P51815; protein.
DR Bgee; ENSG00000186376; Expressed in right adrenal gland cortex and 147 other tissues.
DR Genevisible; P51815; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; NAS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR CDD; cd07936; SCAN; 1.
DR Gene3D; 1.10.4020.10; -; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR038269; SCAN_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF02023; SCAN; 1.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00431; SCAN; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..510
FT /note="Zinc finger protein 75D"
FT /id="PRO_0000047384"
FT DOMAIN 49..131
FT /note="SCAN box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00187"
FT DOMAIN 235..318
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 365..387
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 393..415
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 421..443
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 449..471
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 477..499
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 313..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 138..232
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044460"
FT CONFLICT 409
FT /note="N -> S (in Ref. 1; BAG52399)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 510 AA; 59298 MW; 37D405F102965A24 CRC64;
MAMRELNADS CSSPQMGAMW ETSGSVKENS SQSKKYSTKI ENLGPESACR HFWSFRYHEA
TGPLETISQL QKLCHQWLRP EIHSKEQILE MLVLEQFLSI LPKETQNWVQ KHHPQNVKQA
LVLVEFLQRE PDGTKNEVTA HELGKEAVLL GGTAVAPGFK WKPAEPQPMG VFQKEYWNTY
RVLQEQLGWN THKETQPVYE RAVHDQQMLA LSEQKRIKHW KMASKLILPE SLSLLTFEDV
AVYFSEEEWQ LLNPLEKTLY NDVMQDIYET VISLGLKLKN DTGNDHPISV STSEIQTSGC
EVSKKTRMKI AQKTMGRENP GDTHSVQKWH RAFPRKKRKK PATCKQELPK LMDLHGKGPT
GEKPFKCQEC GKSFRVSSDL IKHHRIHTGE KPYKCQQCDR RFRWSSDLNK HFMTHQGIKP
YRCSWCGKSF SHNTNLHTHQ RIHTGEKPFK CDECGKRFIQ NSHLIKHQRT HTGEQPYTCS
LCKRNFSRRS SLLRHQKLHR RREACLVSPN
