ZN761_HUMAN
ID ZN761_HUMAN Reviewed; 746 AA.
AC Q86XN6; A0A087WXT7; Q6ZNB9;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 3.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Zinc finger protein 761;
GN Name=ZNF761; Synonyms=KIAA2033;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS SER-122; ILE-168;
RP SER-528; GLN-603 AND VAL-678.
RC TISSUE=Brain;
RA Nagase T., Kikuno R., Ohara O.;
RT "The nucleotide sequence of a long cDNA clone isolated from human.";
RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 48-746, AND VARIANTS SER-122 AND
RP ILE-168.
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-205, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC67660.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAD18456.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAD18456.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing in the N-terminal part.; Evidence={ECO:0000305};
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DR EMBL; AB107355; BAC67660.2; ALT_INIT; mRNA.
DR EMBL; AC022137; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF495723; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK131281; BAD18456.1; ALT_SEQ; mRNA.
DR RefSeq; NP_001008401.3; NM_001008401.3.
DR RefSeq; NP_001276880.1; NM_001289951.1.
DR RefSeq; NP_001276881.1; NM_001289952.1.
DR AlphaFoldDB; Q86XN6; -.
DR SMR; Q86XN6; -.
DR BioGRID; 132744; 13.
DR IntAct; Q86XN6; 1.
DR STRING; 9606.ENSP00000480218; -.
DR iPTMnet; Q86XN6; -.
DR PhosphoSitePlus; Q86XN6; -.
DR BioMuta; ZNF761; -.
DR DMDM; 158706491; -.
DR EPD; Q86XN6; -.
DR jPOST; Q86XN6; -.
DR MassIVE; Q86XN6; -.
DR MaxQB; Q86XN6; -.
DR PeptideAtlas; Q86XN6; -.
DR PRIDE; Q86XN6; -.
DR DNASU; 388561; -.
DR Ensembl; ENST00000432094.6; ENSP00000480218.1; ENSG00000160336.17.
DR Ensembl; ENST00000684525.1; ENSP00000507666.1; ENSG00000160336.17.
DR GeneID; 388561; -.
DR KEGG; hsa:388561; -.
DR MANE-Select; ENST00000684525.1; ENSP00000507666.1; NM_001289951.2; NP_001276880.1.
DR UCSC; uc032icc.1; human.
DR CTD; 388561; -.
DR GeneCards; ZNF761; -.
DR HGNC; HGNC:23179; ZNF761.
DR HPA; ENSG00000160336; Tissue enriched (prostate).
DR neXtProt; NX_Q86XN6; -.
DR OpenTargets; ENSG00000160336; -.
DR PharmGKB; PA145149911; -.
DR VEuPathDB; HostDB:ENSG00000160336; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000154397; -.
DR InParanoid; Q86XN6; -.
DR OMA; DQSHARN; -.
DR PhylomeDB; Q86XN6; -.
DR PathwayCommons; Q86XN6; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q86XN6; -.
DR BioGRID-ORCS; 388561; 4 hits in 124 CRISPR screens.
DR GenomeRNAi; 388561; -.
DR Pharos; Q86XN6; Tdark.
DR PRO; PR:Q86XN6; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q86XN6; protein.
DR Bgee; ENSG00000160336; Expressed in prostate gland and 98 other tissues.
DR ExpressionAtlas; Q86XN6; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 12.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 19.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 10.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 17.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 19.
PE 1: Evidence at protein level;
KW DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Ubl conjugation; Zinc;
KW Zinc-finger.
FT CHAIN 1..746
FT /note="Zinc finger protein 761"
FT /id="PRO_0000306880"
FT DOMAIN 8..81
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 215..237
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 242..264
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 270..292
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 298..320
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 326..348
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 354..376
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 382..404
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 410..432
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 438..460
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 466..488
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 494..516
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 522..544
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 550..572
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 578..600
FT /note="C2H2-type 14; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 606..628
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 634..656
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 662..684
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 690..712
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 718..740
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CROSSLNK 205
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VARIANT 122
FT /note="I -> S (in dbSNP:rs2708743)"
FT /evidence="ECO:0000269|PubMed:14702039, ECO:0000269|Ref.1"
FT /id="VAR_035335"
FT VARIANT 168
FT /note="V -> I (in dbSNP:rs1984432)"
FT /evidence="ECO:0000269|PubMed:14702039, ECO:0000269|Ref.1"
FT /id="VAR_035336"
FT VARIANT 528
FT /note="G -> S (in dbSNP:rs2708742)"
FT /evidence="ECO:0000269|Ref.1"
FT /id="VAR_035337"
FT VARIANT 603
FT /note="E -> Q (in dbSNP:rs2617726)"
FT /evidence="ECO:0000269|Ref.1"
FT /id="VAR_035338"
FT VARIANT 678
FT /note="I -> V (in dbSNP:rs139713552)"
FT /evidence="ECO:0000269|Ref.1"
FT /id="VAR_080210"
FT CONFLICT 317
FT /note="R -> S (in Ref. 3; BAD18456)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 746 AA; 87716 MW; 7DE0524FF2673CA0 CRC64;
MAFSQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLDIS SKCTMKEFLS
TAQGNREVFH AGTLQIHESH HNGDFCYQDV DKDIHDYEFQ WQEDERNGHE APMTKIKKLT
GITERYDQSH ARNKPIKDQL GSSFHSHLPE MHIFQTEEKI DNQVVKSVHD ASLVSTAQRI
SCRPKTHISN NHGNNFWNSS LLTQKQEVHM REKSFQCNES GKAFNYSSLL RKHQIIHLAD
KYKCDVCGKL FNQKRNLACH RRCHTGENPY KCNECGKTFS QTSSLTCHRR LHTGEKPYKC
EECDKAFHFK SILERHRIIH TEEKPYKCNE CGKTFRQKSI LTRHHRLHTG EKPYKCNECG
KTFSHKSSLT CHHRLHTGEK PYKCNECGKT FSHKSSLTCH RRLHTGEKPY KCEECDKAYS
FRSNFEIHRK IHTEDNAYKC NECGKTFSRT SSLTCHRRRH TGEQPYKCEE CDKAFRFKSN
LERHRRIHTG EKPYKCNECG KTFSRKSYLT CHHRLHTGEK AYKCNECGKT FSWKSSLTCH
RRLHSGEKPY KCKECGKTFN QQLTLKRHRR LHSGENPYKC EDSDKAYSFK SNLEIHQKIH
TEENPYKCNE CGKTFSRTSS LTCHRRLHTG EKPYKCEECD KAFRVKSNLE GHRRIHTGEK
PYKCNECGKT FSRKSYFICH HRLHTGEKPY KCNECGKNFS QKSSLICHHR LHTGEKPYKC
NECGKTFSQK SNLTCHRRLH TGEKQV
