ZN763_HUMAN
ID ZN763_HUMAN Reviewed; 394 AA.
AC Q0D2J5; B3KRU3; B4DRE7;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Zinc finger protein 763;
GN Name=ZNF763;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q0D2J5; O95257: GADD45G; NbExp=3; IntAct=EBI-10226414, EBI-448202;
CC Q0D2J5; Q9UMX1: SUFU; NbExp=3; IntAct=EBI-10226414, EBI-740595;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q0D2J5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q0D2J5-2; Sequence=VSP_039173;
CC Name=3;
CC IsoId=Q0D2J5-3; Sequence=VSP_055970;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK092240; BAG52505.1; -; mRNA.
DR EMBL; AK299224; BAG61259.1; -; mRNA.
DR EMBL; AC008770; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471106; EAW84252.1; -; Genomic_DNA.
DR EMBL; BC105711; AAI05712.2; -; mRNA.
DR EMBL; BC105712; AAI05713.2; -; mRNA.
DR EMBL; BC105713; AAI05714.2; -; mRNA.
DR CCDS; CCDS45982.1; -. [Q0D2J5-2]
DR RefSeq; NP_001012771.1; NM_001012753.1. [Q0D2J5-2]
DR AlphaFoldDB; Q0D2J5; -.
DR SMR; Q0D2J5; -.
DR BioGRID; 129857; 5.
DR IntAct; Q0D2J5; 2.
DR STRING; 9606.ENSP00000467286; -.
DR iPTMnet; Q0D2J5; -.
DR PhosphoSitePlus; Q0D2J5; -.
DR BioMuta; ZNF763; -.
DR DMDM; 187671927; -.
DR jPOST; Q0D2J5; -.
DR MassIVE; Q0D2J5; -.
DR MaxQB; Q0D2J5; -.
DR PaxDb; Q0D2J5; -.
DR PeptideAtlas; Q0D2J5; -.
DR PRIDE; Q0D2J5; -.
DR ProteomicsDB; 4947; -.
DR ProteomicsDB; 58741; -. [Q0D2J5-1]
DR ProteomicsDB; 58742; -. [Q0D2J5-2]
DR Antibodypedia; 25973; 103 antibodies from 18 providers.
DR DNASU; 284390; -.
DR Ensembl; ENST00000343949.9; ENSP00000369774.2; ENSG00000197054.12. [Q0D2J5-2]
DR Ensembl; ENST00000358987.8; ENSP00000402017.1; ENSG00000197054.12. [Q0D2J5-1]
DR GeneID; 284390; -.
DR KEGG; hsa:284390; -.
DR MANE-Select; ENST00000358987.8; ENSP00000402017.1; NM_001367172.2; NP_001354101.1.
DR UCSC; uc002msv.4; human. [Q0D2J5-1]
DR CTD; 284390; -.
DR DisGeNET; 284390; -.
DR GeneCards; ZNF763; -.
DR HGNC; HGNC:27614; ZNF763.
DR HPA; ENSG00000197054; Low tissue specificity.
DR neXtProt; NX_Q0D2J5; -.
DR OpenTargets; ENSG00000197054; -.
DR PharmGKB; PA162410298; -.
DR VEuPathDB; HostDB:ENSG00000197054; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163273; -.
DR HOGENOM; CLU_002678_0_10_1; -.
DR InParanoid; Q0D2J5; -.
DR OMA; IEYEYKN; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q0D2J5; -.
DR TreeFam; TF338854; -.
DR PathwayCommons; Q0D2J5; -.
DR SignaLink; Q0D2J5; -.
DR BioGRID-ORCS; 284390; 189 hits in 1014 CRISPR screens.
DR GenomeRNAi; 284390; -.
DR Pharos; Q0D2J5; Tdark.
DR PRO; PR:Q0D2J5; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q0D2J5; protein.
DR Bgee; ENSG00000197054; Expressed in granulocyte and 117 other tissues.
DR ExpressionAtlas; Q0D2J5; baseline and differential.
DR Genevisible; Q0D2J5; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..394
FT /note="Zinc finger protein 763"
FT /id="PRO_0000330294"
FT DOMAIN 4..86
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 144..166
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 172..194
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 200..222
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 228..250
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 256..278
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 284..306
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 312..334
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 340..362
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 1..122
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055970"
FT VAR_SEQ 1
FT /note="M -> MMFQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_039173"
FT VARIANT 324
FT /note="Y -> H (in dbSNP:rs7254529)"
FT /id="VAR_057450"
FT VARIANT 327
FT /note="Y -> H (in dbSNP:rs7254529)"
FT /id="VAR_042692"
SQ SEQUENCE 394 AA; 46099 MW; C9DA5FBF2D5BB65D CRC64;
MDPVACEDVA VNFTQEEWAL LDISQRKLYR EVMLETFRNL TSIGKKWKDQ NIEYEYQNPR
RNFRSLIEGN VNEIKEDSHC GETFTQVPDD RLNFQEKKAS PEAKSCDNFV CGEVGIGNSS
FNMNIRGDIG HKAYEYQDYA PKPYKCQQPK KAFRYHPSFR TQERNHTGEK PYACKECGKT
FISHSGIRRR MVMHSGDGPY KCKFCGKAVH CLRLYLIHER THTGEKPYEC KQCVKSFSYS
ATHRIHERTH TGEKPYECQQ CGKAFHSSSS FQAHKRTHTG GKPYECKQCG KSFSWCHSFQ
IHERTHTGEK PCECSKCNKA FRSYRSYLRH KRSHTGEKPY QCKECRKAFT YPSSLRRHER
THSAKKPYEC KQCGKALSYK FSNTPKNALW RKTL
