ZN764_HUMAN
ID ZN764_HUMAN Reviewed; 408 AA.
AC Q96H86; A8MZF4; B3KSN2; H9KV99; Q9BWS1;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Zinc finger protein 764;
GN Name=ZNF764;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT VAL-332.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q96H86; Q9H6L4: ARMC7; NbExp=3; IntAct=EBI-745775, EBI-742909;
CC Q96H86; Q8NA61-2: CBY2; NbExp=3; IntAct=EBI-745775, EBI-11524851;
CC Q96H86; Q86Z20: CCDC125; NbExp=3; IntAct=EBI-745775, EBI-11977221;
CC Q96H86; P49760: CLK2; NbExp=3; IntAct=EBI-745775, EBI-750020;
CC Q96H86; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-745775, EBI-3867333;
CC Q96H86; Q86UW9: DTX2; NbExp=3; IntAct=EBI-745775, EBI-740376;
CC Q96H86; Q92997: DVL3; NbExp=3; IntAct=EBI-745775, EBI-739789;
CC Q96H86; Q5TD97: FHL5; NbExp=3; IntAct=EBI-745775, EBI-750641;
CC Q96H86; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-745775, EBI-5916454;
CC Q96H86; P52597: HNRNPF; NbExp=3; IntAct=EBI-745775, EBI-352986;
CC Q96H86; Q9UJC3: HOOK1; NbExp=3; IntAct=EBI-745775, EBI-746704;
CC Q96H86; O00505: KPNA3; NbExp=3; IntAct=EBI-745775, EBI-358297;
CC Q96H86; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-745775, EBI-11749135;
CC Q96H86; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-745775, EBI-10172290;
CC Q96H86; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-745775, EBI-10172052;
CC Q96H86; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-745775, EBI-10176379;
CC Q96H86; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-745775, EBI-14065470;
CC Q96H86; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-745775, EBI-11958132;
CC Q96H86; Q99750: MDFI; NbExp=4; IntAct=EBI-745775, EBI-724076;
CC Q96H86; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-745775, EBI-10172526;
CC Q96H86; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-745775, EBI-11522433;
CC Q96H86; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-745775, EBI-79165;
CC Q96H86; O75864: PPP1R37; NbExp=3; IntAct=EBI-745775, EBI-5235692;
CC Q96H86; Q9UMX1: SUFU; NbExp=5; IntAct=EBI-745775, EBI-740595;
CC Q96H86; O00635: TRIM38; NbExp=3; IntAct=EBI-745775, EBI-2130415;
CC Q96H86; Q9Y3S2: ZNF330; NbExp=3; IntAct=EBI-745775, EBI-373456;
CC Q96H86; Q9H9D4: ZNF408; NbExp=3; IntAct=EBI-745775, EBI-347633;
CC Q96H86; Q96EG3: ZNF837; NbExp=3; IntAct=EBI-745775, EBI-11962574;
CC Q96H86; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-745775, EBI-527853;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96H86-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96H86-2; Sequence=VSP_045352;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK093992; BAG52794.1; -; mRNA.
DR EMBL; AC002310; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC000016; AAH00016.2; -; mRNA.
DR EMBL; BC008821; AAH08821.1; -; mRNA.
DR CCDS; CCDS10683.1; -. [Q96H86-1]
DR CCDS; CCDS54001.1; -. [Q96H86-2]
DR RefSeq; NP_001166150.1; NM_001172679.1. [Q96H86-2]
DR RefSeq; NP_219363.2; NM_033410.3. [Q96H86-1]
DR AlphaFoldDB; Q96H86; -.
DR SMR; Q96H86; -.
DR BioGRID; 124959; 91.
DR IntAct; Q96H86; 60.
DR STRING; 9606.ENSP00000252797; -.
DR iPTMnet; Q96H86; -.
DR PhosphoSitePlus; Q96H86; -.
DR BioMuta; ZNF764; -.
DR DMDM; 218511973; -.
DR jPOST; Q96H86; -.
DR MassIVE; Q96H86; -.
DR MaxQB; Q96H86; -.
DR PaxDb; Q96H86; -.
DR PeptideAtlas; Q96H86; -.
DR PRIDE; Q96H86; -.
DR ProteomicsDB; 46246; -.
DR ProteomicsDB; 76712; -. [Q96H86-1]
DR Antibodypedia; 837; 102 antibodies from 18 providers.
DR DNASU; 92595; -.
DR Ensembl; ENST00000252797.6; ENSP00000252797.2; ENSG00000169951.10. [Q96H86-1]
DR Ensembl; ENST00000395091.3; ENSP00000378526.2; ENSG00000169951.10. [Q96H86-2]
DR GeneID; 92595; -.
DR KEGG; hsa:92595; -.
DR MANE-Select; ENST00000395091.3; ENSP00000378526.2; NM_001172679.2; NP_001166150.1. [Q96H86-2]
DR UCSC; uc002dyq.4; human. [Q96H86-1]
DR CTD; 92595; -.
DR DisGeNET; 92595; -.
DR GeneCards; ZNF764; -.
DR HGNC; HGNC:28200; ZNF764.
DR HPA; ENSG00000169951; Low tissue specificity.
DR MIM; 619524; gene.
DR neXtProt; NX_Q96H86; -.
DR OpenTargets; ENSG00000169951; -.
DR PharmGKB; PA162410311; -.
DR VEuPathDB; HostDB:ENSG00000169951; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000160032; -.
DR HOGENOM; CLU_002678_13_1_1; -.
DR InParanoid; Q96H86; -.
DR OMA; RRHGCYV; -.
DR PhylomeDB; Q96H86; -.
DR TreeFam; TF337922; -.
DR PathwayCommons; Q96H86; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q96H86; -.
DR BioGRID-ORCS; 92595; 14 hits in 1100 CRISPR screens.
DR ChiTaRS; ZNF764; human.
DR GenomeRNAi; 92595; -.
DR Pharos; Q96H86; Tdark.
DR PRO; PR:Q96H86; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q96H86; protein.
DR Bgee; ENSG00000169951; Expressed in apex of heart and 159 other tissues.
DR ExpressionAtlas; Q96H86; baseline and differential.
DR Genevisible; Q96H86; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 6.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..408
FT /note="Zinc finger protein 764"
FT /id="PRO_0000274398"
FT DOMAIN 26..97
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 175..197
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 203..225
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 231..253
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 259..281
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 287..309
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 315..337
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 343..365
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 91..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..120
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 104
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_045352"
FT VARIANT 332
FT /note="A -> V (in dbSNP:rs17850402)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_047845"
FT CONFLICT 382
FT /note="V -> A (in Ref. 1; BAG52794)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 408 AA; 44943 MW; 9D8A57109ACD38D0 CRC64;
MAPPLAPLPP RDPNGAGPEW REPGAVSFAD VAVYFCREEW GCLRPAQRAL YRDVMRETYG
HLSALGIGGN KPALISWVEE EAELWGPAAQ DPEVAKCQTQ TDPADSRNKK KERQREGTGA
LEKPDPVAAG SPGLKSPQAP SAGPPYGWEQ LSKAPHRGRP SLCAHPPVPR ADQRHGCYVC
GKSFAWRSTL VEHVYSHTGE KPFHCTDCGK GFGHASSLSK HRAIHRGERP HRCLECGRAF
TQRSALTSHL RVHTGEKPYG CADCGRRFSQ SSALYQHRRV HSGETPFPCP DCGRAFAYPS
DLRRHVRTHT GEKPYPCPDC GRCFRQSSEM AAHRRTHSGE KPYPCPQCGR RFGQKSAVAK
HQWVHRPGAG GHRGRVAGRL SVTLTPGHGD LDPPVGFQLY PEIFQECG
