ZN770_MOUSE
ID ZN770_MOUSE Reviewed; 705 AA.
AC Q8BIQ8; Q3TPP6; Q8BK15; Q8BLQ1;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Zinc finger protein 770;
GN Name=Znf770; Synonyms=Zfp770;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain cortex, Embryo, and Olfactory bulb;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK032578; BAC27932.1; -; mRNA.
DR EMBL; AK043843; BAC31677.1; -; mRNA.
DR EMBL; AK077547; BAC36857.1; -; mRNA.
DR EMBL; AK164226; BAE37689.1; -; mRNA.
DR EMBL; AL844569; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS16566.1; -.
DR RefSeq; NP_780675.1; NM_175466.4.
DR RefSeq; XP_011237766.1; XM_011239464.2.
DR AlphaFoldDB; Q8BIQ8; -.
DR SMR; Q8BIQ8; -.
DR BioGRID; 230737; 18.
DR STRING; 10090.ENSMUSP00000052194; -.
DR iPTMnet; Q8BIQ8; -.
DR PhosphoSitePlus; Q8BIQ8; -.
DR PaxDb; Q8BIQ8; -.
DR PRIDE; Q8BIQ8; -.
DR Antibodypedia; 9792; 19 antibodies from 10 providers.
DR DNASU; 228491; -.
DR Ensembl; ENSMUST00000050668; ENSMUSP00000052194; ENSMUSG00000040321.
DR GeneID; 228491; -.
DR KEGG; mmu:228491; -.
DR UCSC; uc008lqj.2; mouse.
DR CTD; 228491; -.
DR MGI; MGI:2445100; Zfp770.
DR VEuPathDB; HostDB:ENSMUSG00000040321; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000161963; -.
DR HOGENOM; CLU_002678_44_7_1; -.
DR InParanoid; Q8BIQ8; -.
DR OMA; ENIHTGH; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8BIQ8; -.
DR TreeFam; TF335560; -.
DR Reactome; R-MMU-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 228491; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Zfp770; mouse.
DR PRO; PR:Q8BIQ8; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8BIQ8; protein.
DR Bgee; ENSMUSG00000040321; Expressed in manus and 212 other tissues.
DR Genevisible; Q8BIQ8; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 7.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE 2: Evidence at transcript level;
KW DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Ubl conjugation; Zinc;
KW Zinc-finger.
FT CHAIN 1..705
FT /note="Zinc finger protein 770"
FT /id="PRO_0000280437"
FT ZN_FING 31..53
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 59..81
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 85..107
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 164..186
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 192..214
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 220..242
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 298..322
FT /note="C2H2-type 7; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 485..507
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 513..535
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 640..662
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 668..690
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CROSSLNK 16
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q6IQ21"
FT CROSSLNK 116
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q6IQ21"
FT CROSSLNK 124
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q6IQ21"
FT CROSSLNK 149
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q6IQ21"
FT CROSSLNK 266
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q6IQ21"
FT CROSSLNK 698
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q6IQ21"
FT CONFLICT 47
FT /note="A -> G (in Ref. 1; BAC31677)"
FT /evidence="ECO:0000305"
FT CONFLICT 230
FT /note="K -> E (in Ref. 1; BAE37689)"
FT /evidence="ECO:0000305"
FT CONFLICT 256
FT /note="K -> R (in Ref. 1; BAC36857)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 705 AA; 81252 MW; D3A078CC61CB4B89 CRC64;
MPLRNVMAEN NFKMLKIQQC VANKLPRNRP YICNICFKHF ETPSKLARHY LIHTGQKPFE
CDVCHKNFRQ LVHLERHQLT HNLPFSCNIC QRHFKNLKTF VKHQQLHNES YHNDVKVRRL
LETKQEKPVY GMCNTFTADE RWALHPCSKS DATYSTTKRR KNIHACTICG KMFPSQSKLD
RHSLIHTGQR PFKCVLCSKS FRQSTHLKIH QLTHSEERPF QCCFCQKGFK IQSKLLKHKQ
IHTRNKTLQN LPLKVKSPES CPLPNKLNAK QDAFESGDMG ESEENNPLDV HSIYIVPFQC
SECEECFESE QILNGHKCLP ARGGRVPSRL KRSCNYKTIV KKLLAKLKRA GGKKSDDLQS
EKKRTFKSNY LKNCERSSGK PNIEQTQRTF VGSLSRHGSY KTVSKKKKKT LALPFSWQKQ
FQSQNTGKSL QGILTTGSIL SMDGSVNNKD LSIYGSSGEE YLNCDMLQCG FSDSSENIHT
GHKMCPCDKC DKVFPSISKL QRHYLIHTGQ RPFDCNVCGK SFRQSAHLKR HKLTHIEKIP
YSSFWRVDFG NVNQLFIHPS DDVSYNASQQ CEGLGSQSCE SSESSQVSEI EVKVEPEDFL
LGSHCRSRQS YLANALVESE QSHHCYSYLG RPERSDGLLY QCSVCCKHFR SPSKLERHYL
IHAGQKPFEC SVCGKTFRQA PHWKRHQLTH FKERPQEKVV LDSTV
