ZN771_HUMAN
ID ZN771_HUMAN Reviewed; 317 AA.
AC Q7L3S4; Q8TAQ7; Q9NYI6;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Zinc finger protein 771;
DE AltName: Full=Mesenchymal stem cell protein DSC43;
GN Name=ZNF771;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASN-207.
RC TISSUE=Brain, and Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 35-317.
RA van den Bos C., Mbalaviele G., Thiede M.;
RT "cDNA DSC43 expressed by osteogenic human mesenchymal stem cells.";
RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [4]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-33, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF65445.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC011870; AAH11870.2; -; mRNA.
DR EMBL; BC026192; AAH26192.2; -; mRNA.
DR EMBL; AF242768; AAF65445.1; ALT_INIT; mRNA.
DR CCDS; CCDS45460.1; -.
DR RefSeq; NP_001135777.1; NM_001142305.1.
DR RefSeq; NP_057727.2; NM_016643.3.
DR AlphaFoldDB; Q7L3S4; -.
DR SMR; Q7L3S4; -.
DR BioGRID; 119480; 253.
DR IntAct; Q7L3S4; 17.
DR STRING; 9606.ENSP00000323945; -.
DR iPTMnet; Q7L3S4; -.
DR PhosphoSitePlus; Q7L3S4; -.
DR BioMuta; ZNF771; -.
DR DMDM; 74759003; -.
DR EPD; Q7L3S4; -.
DR MassIVE; Q7L3S4; -.
DR MaxQB; Q7L3S4; -.
DR PaxDb; Q7L3S4; -.
DR PeptideAtlas; Q7L3S4; -.
DR PRIDE; Q7L3S4; -.
DR ProteomicsDB; 68771; -.
DR Antibodypedia; 27266; 81 antibodies from 19 providers.
DR DNASU; 51333; -.
DR Ensembl; ENST00000319296.10; ENSP00000323945.5; ENSG00000179965.12.
DR Ensembl; ENST00000434417.1; ENSP00000416197.1; ENSG00000179965.12.
DR GeneID; 51333; -.
DR KEGG; hsa:51333; -.
DR MANE-Select; ENST00000319296.10; ENSP00000323945.5; NM_001142305.2; NP_001135777.1.
DR UCSC; uc002dyd.4; human.
DR CTD; 51333; -.
DR DisGeNET; 51333; -.
DR GeneCards; ZNF771; -.
DR HGNC; HGNC:29653; ZNF771.
DR HPA; ENSG00000179965; Low tissue specificity.
DR neXtProt; NX_Q7L3S4; -.
DR PharmGKB; PA162410347; -.
DR VEuPathDB; HostDB:ENSG00000179965; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162367; -.
DR HOGENOM; CLU_002678_2_6_1; -.
DR InParanoid; Q7L3S4; -.
DR OMA; ATPTERC; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q7L3S4; -.
DR TreeFam; TF337055; -.
DR PathwayCommons; Q7L3S4; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q7L3S4; -.
DR BioGRID-ORCS; 51333; 20 hits in 1099 CRISPR screens.
DR ChiTaRS; ZNF771; human.
DR GenomeRNAi; 51333; -.
DR Pharos; Q7L3S4; Tdark.
DR PRO; PR:Q7L3S4; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q7L3S4; protein.
DR Bgee; ENSG00000179965; Expressed in buccal mucosa cell and 101 other tissues.
DR ExpressionAtlas; Q7L3S4; baseline and differential.
DR Genevisible; Q7L3S4; HS.
DR GO; GO:0005730; C:nucleolus; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 8.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF57667; SSF57667; 5.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 1: Evidence at protein level;
KW DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Ubl conjugation; Zinc;
KW Zinc-finger.
FT CHAIN 1..317
FT /note="Zinc finger protein 771"
FT /id="PRO_0000280439"
FT ZN_FING 63..85
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 91..113
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 119..141
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 147..169
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 175..197
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 203..225
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 231..253
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 259..281
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..45
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 33
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VARIANT 207
FT /note="D -> N (in dbSNP:rs17852362)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_031150"
SQ SEQUENCE 317 AA; 35702 MW; BF752DE568010B88 CRC64;
MPGEQQAEEE EEEEMQEEMV LLVKGEEDEG EEKYEVVKLK IPMDNKEVPG EAPAPSADPA
RPHACPDCGR AFARRSTLAK HARTHTGERP FGCTECGRRF SQKSALTKHG RTHTGERPYE
CPECDKRFSA ASNLRQHRRR HTGEKPYACA HCGRRFAQSS NYAQHLRVHT GEKPYACPDC
GRAFGGSSCL ARHRRTHTGE RPYACADCGT RFAQSSALAK HRRVHTGEKP HRCAVCGRRF
GHRSNLAEHA RTHTGERPYP CAECGRRFRL SSHFIRHRRA HMRRRLYICA GCGRDFKLPP
GATAATATER CPECEGS
