ZN771_MOUSE
ID ZN771_MOUSE Reviewed; 317 AA.
AC Q8BJ90; B2RSX6; Q6P5I0;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Zinc finger protein 771;
GN Name=Znf771; Synonyms=Zfp771;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain cortex;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK090240; BAC41144.1; -; mRNA.
DR EMBL; BC062882; AAH62882.1; -; mRNA.
DR EMBL; BC139048; AAI39049.1; -; mRNA.
DR EMBL; BC139049; AAI39050.1; -; mRNA.
DR EMBL; BC145524; AAI45525.1; -; mRNA.
DR CCDS; CCDS21861.1; -.
DR RefSeq; NP_796336.1; NM_177362.3.
DR RefSeq; XP_006507906.1; XM_006507843.2.
DR AlphaFoldDB; Q8BJ90; -.
DR SMR; Q8BJ90; -.
DR BioGRID; 232624; 1.
DR STRING; 10090.ENSMUSP00000056959; -.
DR iPTMnet; Q8BJ90; -.
DR PhosphoSitePlus; Q8BJ90; -.
DR EPD; Q8BJ90; -.
DR MaxQB; Q8BJ90; -.
DR PaxDb; Q8BJ90; -.
DR PeptideAtlas; Q8BJ90; -.
DR PRIDE; Q8BJ90; -.
DR ProteomicsDB; 299601; -.
DR Antibodypedia; 27266; 81 antibodies from 19 providers.
DR DNASU; 244216; -.
DR Ensembl; ENSMUST00000052509; ENSMUSP00000056959; ENSMUSG00000054716.
DR GeneID; 244216; -.
DR KEGG; mmu:244216; -.
DR UCSC; uc009juv.1; mouse.
DR CTD; 244216; -.
DR MGI; MGI:2442050; Zfp771.
DR VEuPathDB; HostDB:ENSMUSG00000054716; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162367; -.
DR HOGENOM; CLU_002678_2_6_1; -.
DR InParanoid; Q8BJ90; -.
DR OMA; ATPTERC; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8BJ90; -.
DR TreeFam; TF350834; -.
DR BioGRID-ORCS; 244216; 7 hits in 73 CRISPR screens.
DR ChiTaRS; Zfp771; mouse.
DR PRO; PR:Q8BJ90; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8BJ90; protein.
DR Bgee; ENSMUSG00000054716; Expressed in internal carotid artery and 218 other tissues.
DR ExpressionAtlas; Q8BJ90; baseline and differential.
DR Genevisible; Q8BJ90; MM.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 8.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF57667; SSF57667; 5.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 2: Evidence at transcript level;
KW DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Ubl conjugation; Zinc;
KW Zinc-finger.
FT CHAIN 1..317
FT /note="Zinc finger protein 771"
FT /id="PRO_0000280440"
FT ZN_FING 63..85
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 91..113
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 119..141
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 147..169
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 175..197
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 203..225
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 231..253
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 259..281
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CROSSLNK 33
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q7L3S4"
SQ SEQUENCE 317 AA; 35767 MW; 308C09E5311A1A3B CRC64;
MPGEQQAEEE EEEEMQEEMV LLVKGEEEEG EEKYEVVKLK IPVDNKEVAS QMPAPSADPA
RPHACPDCGR AFARRSTLAK HARTHTGERP FACTECGRCF SQKSALTKHG RTHTGERPYQ
CPECDKRFSA ASNLRQHRRR HTGEKPYACA HCGRRFAQSS NYAQHLRVHT GEKPYACPDC
GRAFGGSSCL ARHRRTHTGE RPYACADCGT RFAQSSALAK HRRVHTGEKP HRCAVCGRRF
GHRSNLAEHA RTHTGERPYP CTECGRRFRL SSHFIRHRRA HMRRRLYICA GCGRDFKLPA
SATAATPTER CPECEGS
