ZN772_HUMAN
ID ZN772_HUMAN Reviewed; 489 AA.
AC Q68DY9; A6NJK9; B4DH56; B4DYS0;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 2.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Zinc finger protein 772;
GN Name=ZNF772;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Brain, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANTS
RP TRP-182 AND LEU-218.
RC TISSUE=Endometrial tumor, and Fetal kidney;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- INTERACTION:
CC Q68DY9; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-10249148, EBI-16439278;
CC Q68DY9; P50542: PEX5; NbExp=3; IntAct=EBI-10249148, EBI-597835;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q68DY9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q68DY9-2; Sequence=VSP_021882;
CC Name=3;
CC IsoId=Q68DY9-3; Sequence=VSP_043423;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK294941; BAG58017.1; -; mRNA.
DR EMBL; AK302574; BAG63832.1; -; mRNA.
DR EMBL; BX647068; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; CR749225; CAH18081.1; -; mRNA.
DR EMBL; AC003005; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC004076; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS33133.1; -. [Q68DY9-1]
DR CCDS; CCDS46210.1; -. [Q68DY9-3]
DR CCDS; CCDS82406.1; -. [Q68DY9-2]
DR RefSeq; NP_001019767.1; NM_001024596.2. [Q68DY9-1]
DR RefSeq; NP_001137540.1; NM_001144068.1. [Q68DY9-3]
DR RefSeq; NP_001317542.1; NM_001330613.1. [Q68DY9-2]
DR RefSeq; XP_005259001.1; XM_005258944.3. [Q68DY9-2]
DR AlphaFoldDB; Q68DY9; -.
DR SMR; Q68DY9; -.
DR BioGRID; 134722; 7.
DR IntAct; Q68DY9; 2.
DR STRING; 9606.ENSP00000341165; -.
DR iPTMnet; Q68DY9; -.
DR PhosphoSitePlus; Q68DY9; -.
DR BioMuta; ZNF772; -.
DR DMDM; 119368827; -.
DR MassIVE; Q68DY9; -.
DR PaxDb; Q68DY9; -.
DR PeptideAtlas; Q68DY9; -.
DR PRIDE; Q68DY9; -.
DR ProteomicsDB; 66119; -. [Q68DY9-1]
DR ProteomicsDB; 66120; -. [Q68DY9-2]
DR ProteomicsDB; 66121; -. [Q68DY9-3]
DR Antibodypedia; 33253; 91 antibodies from 13 providers.
DR DNASU; 400720; -.
DR Ensembl; ENST00000343280.8; ENSP00000341165.4; ENSG00000197128.13. [Q68DY9-1]
DR Ensembl; ENST00000356584.8; ENSP00000348992.3; ENSG00000197128.13. [Q68DY9-3]
DR Ensembl; ENST00000427512.6; ENSP00000395967.2; ENSG00000197128.13. [Q68DY9-2]
DR GeneID; 400720; -.
DR KEGG; hsa:400720; -.
DR MANE-Select; ENST00000356584.8; ENSP00000348992.3; NM_001144068.2; NP_001137540.1. [Q68DY9-3]
DR UCSC; uc002qot.3; human. [Q68DY9-1]
DR CTD; 400720; -.
DR GeneCards; ZNF772; -.
DR HGNC; HGNC:33106; ZNF772.
DR HPA; ENSG00000197128; Low tissue specificity.
DR neXtProt; NX_Q68DY9; -.
DR OpenTargets; ENSG00000197128; -.
DR PharmGKB; PA162410356; -.
DR VEuPathDB; HostDB:ENSG00000197128; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000154734; -.
DR HOGENOM; CLU_002678_57_1_1; -.
DR InParanoid; Q68DY9; -.
DR OMA; PYMCVAC; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q68DY9; -.
DR TreeFam; TF342033; -.
DR PathwayCommons; Q68DY9; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q68DY9; -.
DR BioGRID-ORCS; 400720; 7 hits in 1096 CRISPR screens.
DR ChiTaRS; ZNF772; human.
DR GenomeRNAi; 400720; -.
DR Pharos; Q68DY9; Tdark.
DR PRO; PR:Q68DY9; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q68DY9; protein.
DR Bgee; ENSG00000197128; Expressed in corpus callosum and 110 other tissues.
DR ExpressionAtlas; Q68DY9; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 8.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 10.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 5.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..489
FT /note="Zinc finger protein 772"
FT /id="PRO_0000263689"
FT DOMAIN 27..98
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 144..166
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 172..194
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 266..288
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 294..316
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 322..344
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 350..372
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 378..400
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 406..428
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 434..456
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 462..484
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 1..112
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_021882"
FT VAR_SEQ 67..107
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_043423"
FT VARIANT 182
FT /note="C -> W (in dbSNP:rs2074060)"
FT /evidence="ECO:0000269|PubMed:17974005"
FT /id="VAR_029604"
FT VARIANT 218
FT /note="M -> L (in dbSNP:rs2074059)"
FT /evidence="ECO:0000269|PubMed:17974005"
FT /id="VAR_029605"
FT CONFLICT 369
FT /note="E -> G (in Ref. 2; CAH18081)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 489 AA; 55367 MW; C5F8E4BA5469C32B CRC64;
MAAAEPMGPA QVPMNSEVIV DPIQGQVNFE DVFVYFSQEE WVLLDEAQRL LYRDVMLENF
ALMASLGHTS FMSHIVASLV MGSEPWVPDW VDMTLAVATE TPGGSDPGCW HGMEDEEIPF
EQSFSIGMSQ IRIPKGGPST QKAYPCGTCG LVLKDILHLA EHQETHPGQK PYMCVLCGKQ
FCFSANLHQH QKQHSGEKPF RSDKSRPFLL NNCAVQSMEM SFVTGEACKD FLASSSIFEH
HAPHNEWKPH SNTKCEEASH CGKRHYKCSE CGKTFSRKDS LVQHQRVHTG ERPYECGECG
KTFSRKPILA QHQRIHTGEM PYECGICGKV FNHSSNLIVH QRVHTGARPY KCSECGKAYS
HKSTLVQHES IHTGERPYEC SECGKYFGHK YRLIKHWSVH TGARPYECIA CGKFFSQSSD
LIAHQRVHNG EKPYVCSECG KAFSHKHVLV QHHRIHTGER PYKCSECGKA FRQRASLIRH
WKIHTGERP
