ZN773_HUMAN
ID ZN773_HUMAN Reviewed; 442 AA.
AC Q6PK81; Q96DL8;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Zinc finger protein 773;
DE AltName: Full=Zinc finger protein 419B;
GN Name=ZNF773; Synonyms=ZNF419B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Synovial cell;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q6PK81; Q9UKI8: TLK1; NbExp=3; IntAct=EBI-2686307, EBI-740492;
CC Q6PK81; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-2686307, EBI-725997;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6PK81-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6PK81-2; Sequence=VSP_024870;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK057209; BAB71382.1; -; mRNA.
DR EMBL; BC005167; AAH05167.1; -; mRNA.
DR CCDS; CCDS33134.1; -. [Q6PK81-1]
DR CCDS; CCDS77368.1; -. [Q6PK81-2]
DR RefSeq; NP_001291263.1; NM_001304334.1. [Q6PK81-2]
DR RefSeq; NP_940944.1; NM_198542.2. [Q6PK81-1]
DR AlphaFoldDB; Q6PK81; -.
DR SMR; Q6PK81; -.
DR BioGRID; 131939; 12.
DR IntAct; Q6PK81; 4.
DR STRING; 9606.ENSP00000282292; -.
DR iPTMnet; Q6PK81; -.
DR PhosphoSitePlus; Q6PK81; -.
DR BioMuta; ZNF773; -.
DR DMDM; 74758405; -.
DR EPD; Q6PK81; -.
DR MassIVE; Q6PK81; -.
DR MaxQB; Q6PK81; -.
DR PaxDb; Q6PK81; -.
DR PeptideAtlas; Q6PK81; -.
DR PRIDE; Q6PK81; -.
DR ProteomicsDB; 67236; -. [Q6PK81-1]
DR ProteomicsDB; 67237; -. [Q6PK81-2]
DR Antibodypedia; 33265; 124 antibodies from 18 providers.
DR DNASU; 374928; -.
DR Ensembl; ENST00000282292.9; ENSP00000282292.3; ENSG00000152439.13. [Q6PK81-1]
DR Ensembl; ENST00000598770.5; ENSP00000469416.1; ENSG00000152439.13. [Q6PK81-2]
DR GeneID; 374928; -.
DR KEGG; hsa:374928; -.
DR MANE-Select; ENST00000282292.9; ENSP00000282292.3; NM_198542.3; NP_940944.1.
DR UCSC; uc002qox.4; human. [Q6PK81-1]
DR CTD; 374928; -.
DR GeneCards; ZNF773; -.
DR HGNC; HGNC:30487; ZNF773.
DR HPA; ENSG00000152439; Low tissue specificity.
DR neXtProt; NX_Q6PK81; -.
DR OpenTargets; ENSG00000152439; -.
DR PharmGKB; PA162410357; -.
DR VEuPathDB; HostDB:ENSG00000152439; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163779; -.
DR HOGENOM; CLU_002678_0_2_1; -.
DR InParanoid; Q6PK81; -.
DR OMA; SEEAFHP; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q6PK81; -.
DR TreeFam; TF339848; -.
DR PathwayCommons; Q6PK81; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q6PK81; -.
DR BioGRID-ORCS; 374928; 4 hits in 1022 CRISPR screens.
DR GenomeRNAi; 374928; -.
DR Pharos; Q6PK81; Tdark.
DR PRO; PR:Q6PK81; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q6PK81; protein.
DR Bgee; ENSG00000152439; Expressed in ventricular zone and 98 other tissues.
DR ExpressionAtlas; Q6PK81; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 9.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 5.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..442
FT /note="Zinc finger protein 773"
FT /id="PRO_0000285303"
FT DOMAIN 15..86
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 191..213
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 219..241
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 247..269
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 275..297
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 303..325
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 331..353
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 359..381
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 387..409
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 415..437
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 12
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_024870"
SQ SEQUENCE 442 AA; 50502 MW; 0CBC2E4427C3A01D CRC64;
MAAATLRDPA QQGYVTFEDV AVYFSQEEWR LLDDAQRLLY RNVMLENFTL LASLGLASSK
THEITQLESW EEPFMPAWEV VTSAILRGSW QGAKAEAAAE QSASVEVPSS NVQQHQKQHC
GEKPLKRQEG RVPVLRSCRV HLSEKSLQSR EVGKDLLTSS GVLKHQVTHT GEKSHRSSKS
REAFHAGKRH YKCSECGKAF GQKYLLVQHQ RLHTGEKPYE CSECGKLFSH KSNLFIHQIV
HTGERPYGCS DCGKSFSRNA DLIQHQRVHT GEKPFTCSEC GKAFRHNSTL VQHHRIHTGV
RPYECSECGK LFSFNSSLMK HQRVHTGERP YKCSECGKFY SHKSSLINHW RVHTGERPYE
CSECGKFFSQ SSSLMQHRKV HTGEKPFKCN ECGRFFSENS SLVKHQRVHT GAKPYECREC
GKFFRHSSSL VKHRRIHTGE IQ
