ZN774_HUMAN
ID ZN774_HUMAN Reviewed; 483 AA.
AC Q6NX45; A8K020;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Zinc finger protein 774;
GN Name=ZNF774;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Adrenal gland;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-83.
RC TISSUE=PNS;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- INTERACTION:
CC Q6NX45; Q9UBB4: ATXN10; NbExp=3; IntAct=EBI-10251462, EBI-702390;
CC Q6NX45; Q9BYV9: BACH2; NbExp=3; IntAct=EBI-10251462, EBI-1642333;
CC Q6NX45; Q9BUH8: BEGAIN; NbExp=6; IntAct=EBI-10251462, EBI-742722;
CC Q6NX45; P51451: BLK; NbExp=3; IntAct=EBI-10251462, EBI-2105445;
CC Q6NX45; A0A087WZT3: BOLA2B; NbExp=3; IntAct=EBI-10251462, EBI-12006120;
CC Q6NX45; Q13895: BYSL; NbExp=3; IntAct=EBI-10251462, EBI-358049;
CC Q6NX45; Q9NPB3: CABP2; NbExp=3; IntAct=EBI-10251462, EBI-12011224;
CC Q6NX45; Q13137: CALCOCO2; NbExp=3; IntAct=EBI-10251462, EBI-739580;
CC Q6NX45; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-10251462, EBI-11530605;
CC Q6NX45; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-10251462, EBI-744545;
CC Q6NX45; Q68D86: CCDC102B; NbExp=3; IntAct=EBI-10251462, EBI-10171570;
CC Q6NX45; Q16204: CCDC6; NbExp=3; IntAct=EBI-10251462, EBI-1045350;
CC Q6NX45; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-10251462, EBI-10175300;
CC Q6NX45; Q07002: CDK18; NbExp=3; IntAct=EBI-10251462, EBI-746238;
CC Q6NX45; P55273: CDKN2D; NbExp=3; IntAct=EBI-10251462, EBI-745859;
CC Q6NX45; Q96MT8-3: CEP63; NbExp=3; IntAct=EBI-10251462, EBI-11522539;
CC Q6NX45; Q96Q77: CIB3; NbExp=3; IntAct=EBI-10251462, EBI-10292696;
CC Q6NX45; P27658: COL8A1; NbExp=3; IntAct=EBI-10251462, EBI-747133;
CC Q6NX45; Q9UBL6-2: CPNE7; NbExp=3; IntAct=EBI-10251462, EBI-12012272;
CC Q6NX45; Q86UW9: DTX2; NbExp=3; IntAct=EBI-10251462, EBI-740376;
CC Q6NX45; Q92997: DVL3; NbExp=6; IntAct=EBI-10251462, EBI-739789;
CC Q6NX45; O95967: EFEMP2; NbExp=3; IntAct=EBI-10251462, EBI-743414;
CC Q6NX45; P50402: EMD; NbExp=3; IntAct=EBI-10251462, EBI-489887;
CC Q6NX45; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-10251462, EBI-744099;
CC Q6NX45; Q9H5Z6-2: FAM124B; NbExp=3; IntAct=EBI-10251462, EBI-11986315;
CC Q6NX45; Q9NW38: FANCL; NbExp=3; IntAct=EBI-10251462, EBI-2339898;
CC Q6NX45; A1L4K1: FSD2; NbExp=3; IntAct=EBI-10251462, EBI-5661036;
CC Q6NX45; P60520: GABARAPL2; NbExp=3; IntAct=EBI-10251462, EBI-720116;
CC Q6NX45; P55040: GEM; NbExp=3; IntAct=EBI-10251462, EBI-744104;
CC Q6NX45; P14136: GFAP; NbExp=9; IntAct=EBI-10251462, EBI-744302;
CC Q6NX45; O76003: GLRX3; NbExp=3; IntAct=EBI-10251462, EBI-374781;
CC Q6NX45; Q92805: GOLGA1; NbExp=3; IntAct=EBI-10251462, EBI-6164177;
CC Q6NX45; Q08379: GOLGA2; NbExp=7; IntAct=EBI-10251462, EBI-618309;
CC Q6NX45; P28799: GRN; NbExp=3; IntAct=EBI-10251462, EBI-747754;
CC Q6NX45; Q969Y2: GTPBP3; NbExp=3; IntAct=EBI-10251462, EBI-740290;
CC Q6NX45; P13807: GYS1; NbExp=3; IntAct=EBI-10251462, EBI-740553;
CC Q6NX45; P51124: GZMM; NbExp=3; IntAct=EBI-10251462, EBI-12119998;
CC Q6NX45; A0A024R8L2: hCG_1987119; NbExp=3; IntAct=EBI-10251462, EBI-14103818;
CC Q6NX45; P49639: HOXA1; NbExp=3; IntAct=EBI-10251462, EBI-740785;
CC Q6NX45; P09067: HOXB5; NbExp=3; IntAct=EBI-10251462, EBI-3893317;
CC Q6NX45; O75031: HSF2BP; NbExp=3; IntAct=EBI-10251462, EBI-7116203;
CC Q6NX45; Q14005-2: IL16; NbExp=3; IntAct=EBI-10251462, EBI-17178971;
CC Q6NX45; O15397: IPO8; NbExp=3; IntAct=EBI-10251462, EBI-358808;
CC Q6NX45; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-10251462, EBI-1055254;
CC Q6NX45; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-10251462, EBI-2556193;
CC Q6NX45; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-10251462, EBI-14069005;
CC Q6NX45; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-10251462, EBI-12012928;
CC Q6NX45; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-10251462, EBI-10172290;
CC Q6NX45; P60411: KRTAP10-9; NbExp=6; IntAct=EBI-10251462, EBI-10172052;
CC Q6NX45; Q9BYR2: KRTAP4-5; NbExp=3; IntAct=EBI-10251462, EBI-11993254;
CC Q6NX45; O95751: LDOC1; NbExp=5; IntAct=EBI-10251462, EBI-740738;
CC Q6NX45; Q17RB8: LONRF1; NbExp=3; IntAct=EBI-10251462, EBI-2341787;
CC Q6NX45; Q96A72: MAGOHB; NbExp=3; IntAct=EBI-10251462, EBI-746778;
CC Q6NX45; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-10251462, EBI-10172526;
CC Q6NX45; Q8IVT2: MISP; NbExp=3; IntAct=EBI-10251462, EBI-2555085;
CC Q6NX45; P40692: MLH1; NbExp=3; IntAct=EBI-10251462, EBI-744248;
CC Q6NX45; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-10251462, EBI-11522433;
CC Q6NX45; Q9UHB4: NDOR1; NbExp=3; IntAct=EBI-10251462, EBI-10249760;
CC Q6NX45; Q9HC98-4: NEK6; NbExp=3; IntAct=EBI-10251462, EBI-11750983;
CC Q6NX45; Q8IV28: NID2; NbExp=3; IntAct=EBI-10251462, EBI-10261509;
CC Q6NX45; Q4G0R1: PIBF1; NbExp=3; IntAct=EBI-10251462, EBI-14066006;
CC Q6NX45; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-10251462, EBI-79165;
CC Q6NX45; Q8WWY3: PRPF31; NbExp=3; IntAct=EBI-10251462, EBI-1567797;
CC Q6NX45; P20618: PSMB1; NbExp=3; IntAct=EBI-10251462, EBI-372273;
CC Q6NX45; Q15276: RABEP1; NbExp=3; IntAct=EBI-10251462, EBI-447043;
CC Q6NX45; O75771: RAD51D; NbExp=3; IntAct=EBI-10251462, EBI-1055693;
CC Q6NX45; P57052: RBM11; NbExp=3; IntAct=EBI-10251462, EBI-741332;
CC Q6NX45; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-10251462, EBI-748391;
CC Q6NX45; Q9H788: SH2D4A; NbExp=3; IntAct=EBI-10251462, EBI-747035;
CC Q6NX45; P84022: SMAD3; NbExp=3; IntAct=EBI-10251462, EBI-347161;
CC Q6NX45; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-10251462, EBI-5235340;
CC Q6NX45; O75716: STK16; NbExp=3; IntAct=EBI-10251462, EBI-749295;
CC Q6NX45; Q12933: TRAF2; NbExp=3; IntAct=EBI-10251462, EBI-355744;
CC Q6NX45; Q5T7W7: TSTD2; NbExp=3; IntAct=EBI-10251462, EBI-8994397;
CC Q6NX45; Q70CQ1-2: USP49; NbExp=3; IntAct=EBI-10251462, EBI-12133829;
CC Q6NX45; Q2TAL6: VWC2; NbExp=3; IntAct=EBI-10251462, EBI-11957238;
CC Q6NX45; O76024: WFS1; NbExp=3; IntAct=EBI-10251462, EBI-720609;
CC Q6NX45; P13994: YJU2B; NbExp=3; IntAct=EBI-10251462, EBI-716093;
CC Q6NX45; P49910: ZNF165; NbExp=3; IntAct=EBI-10251462, EBI-741694;
CC Q6NX45; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-10251462, EBI-740727;
CC Q6NX45; Q96MX3: ZNF48; NbExp=3; IntAct=EBI-10251462, EBI-12006434;
CC Q6NX45; Q8TF50: ZNF526; NbExp=3; IntAct=EBI-10251462, EBI-11035148;
CC Q6NX45; Q7Z3I7: ZNF572; NbExp=3; IntAct=EBI-10251462, EBI-10172590;
CC Q6NX45; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-10251462, EBI-6427977;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK289385; BAF82074.1; -; mRNA.
DR EMBL; AC018946; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC067279; AAH67279.1; -; mRNA.
DR CCDS; CCDS32330.1; -.
DR RefSeq; NP_001004309.2; NM_001004309.2.
DR AlphaFoldDB; Q6NX45; -.
DR SMR; Q6NX45; -.
DR BioGRID; 131165; 77.
DR IntAct; Q6NX45; 84.
DR STRING; 9606.ENSP00000346348; -.
DR iPTMnet; Q6NX45; -.
DR PhosphoSitePlus; Q6NX45; -.
DR BioMuta; ZNF774; -.
DR DMDM; 313104065; -.
DR MassIVE; Q6NX45; -.
DR MaxQB; Q6NX45; -.
DR PaxDb; Q6NX45; -.
DR PeptideAtlas; Q6NX45; -.
DR PRIDE; Q6NX45; -.
DR Antibodypedia; 28795; 62 antibodies from 16 providers.
DR DNASU; 342132; -.
DR Ensembl; ENST00000354377.8; ENSP00000346348.3; ENSG00000196391.11.
DR GeneID; 342132; -.
DR KEGG; hsa:342132; -.
DR MANE-Select; ENST00000354377.8; ENSP00000346348.3; NM_001004309.3; NP_001004309.2.
DR UCSC; uc002bpk.5; human.
DR CTD; 342132; -.
DR DisGeNET; 342132; -.
DR GeneCards; ZNF774; -.
DR HGNC; HGNC:33108; ZNF774.
DR HPA; ENSG00000196391; Low tissue specificity.
DR neXtProt; NX_Q6NX45; -.
DR OpenTargets; ENSG00000196391; -.
DR PharmGKB; PA162410358; -.
DR VEuPathDB; HostDB:ENSG00000196391; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163116; -.
DR HOGENOM; CLU_002678_57_0_1; -.
DR InParanoid; Q6NX45; -.
DR OMA; HTDFEHQ; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q6NX45; -.
DR TreeFam; TF336942; -.
DR PathwayCommons; Q6NX45; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q6NX45; -.
DR SIGNOR; Q6NX45; -.
DR BioGRID-ORCS; 342132; 12 hits in 1096 CRISPR screens.
DR GenomeRNAi; 342132; -.
DR Pharos; Q6NX45; Tdark.
DR PRO; PR:Q6NX45; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q6NX45; protein.
DR Bgee; ENSG00000196391; Expressed in skeletal muscle tissue and 101 other tissues.
DR ExpressionAtlas; Q6NX45; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 11.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..483
FT /note="Zinc finger protein 774"
FT /id="PRO_0000263653"
FT DOMAIN 1..64
FT /note="KRAB"
FT ZN_FING 151..173
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 179..201
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 207..229
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 235..257
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 263..285
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 291..313
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 319..341
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 347..369
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 375..397
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 403..425
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 431..453
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 459..481
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 81..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 65
FT /note="P -> L (in dbSNP:rs16944267)"
FT /id="VAR_029596"
FT VARIANT 83
FT /note="N -> S (in dbSNP:rs2589957)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_029597"
FT VARIANT 147
FT /note="V -> I (in dbSNP:rs11854320)"
FT /id="VAR_029598"
SQ SEQUENCE 483 AA; 55068 MW; 88C98561DA99E7A5 CRC64;
MWLGTSGKSG LPGHCLENPL QECHPAQLEE WALKGISRPS VISQPEQKEE PWVLPLQNFE
ARKIPRESHT DCEHQVAKLN QDNSETAEQC GTSSERTNKD LSHTLSWGGN WEQGLELEGQ
HGTLPGEGQL ESFSQERDLN KLLDGYVGEK PMCAECGKSF NQSSYLIRHL RTHTGERPYT
CIECGKGFKQ SSDLVTHRRT HTGEKPYQCK GCEKKFSDSS TLIKHQRTHT GERPYECPEC
GKTFGRKPHL IMHQRTHTGE KPYACLECHK SFSRSSNFIT HQRTHTGVKP YRCNDCGESF
SQSSDLIKHQ RTHTGERPFK CPECGKGFRD SSHFVAHMST HSGERPFSCP DCHKSFSQSS
HLVTHQRTHT GERPFKCENC GKGFADSSAL IKHQRIHTGE RPYKCGECGK SFNQSSHFIT
HQRIHLGDRP YRCPECGKTF NQRSHFLTHQ RTHTGEKPFH CSKCNKSFRQ KAHLLCHQNT
HLI
