ZN775_HUMAN
ID ZN775_HUMAN Reviewed; 537 AA.
AC Q96BV0; Q8IY24;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2004, sequence version 2.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Zinc finger protein 775;
GN Name=ZNF775;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-533, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q96BV0; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-7149881, EBI-3866279;
CC Q96BV0; Q8NHQ1: CEP70; NbExp=3; IntAct=EBI-7149881, EBI-739624;
CC Q96BV0; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-7149881, EBI-3867333;
CC Q96BV0; Q92997: DVL3; NbExp=3; IntAct=EBI-7149881, EBI-739789;
CC Q96BV0; Q96KQ7: EHMT2; NbExp=3; IntAct=EBI-7149881, EBI-744366;
CC Q96BV0; Q8IZU1: FAM9A; NbExp=3; IntAct=EBI-7149881, EBI-8468186;
CC Q96BV0; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-7149881, EBI-10171774;
CC Q96BV0; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-7149881, EBI-11522433;
CC Q96BV0; Q9H2G4: TSPYL2; NbExp=3; IntAct=EBI-7149881, EBI-947459;
CC Q96BV0; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-7149881, EBI-527853;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; BC015152; AAH15152.2; -; mRNA.
DR CCDS; CCDS43678.1; -.
DR RefSeq; NP_775951.2; NM_173680.3.
DR AlphaFoldDB; Q96BV0; -.
DR SMR; Q96BV0; -.
DR BioGRID; 130261; 24.
DR IntAct; Q96BV0; 20.
DR MINT; Q96BV0; -.
DR STRING; 9606.ENSP00000330838; -.
DR iPTMnet; Q96BV0; -.
DR PhosphoSitePlus; Q96BV0; -.
DR BioMuta; ZNF775; -.
DR DMDM; 74760747; -.
DR EPD; Q96BV0; -.
DR jPOST; Q96BV0; -.
DR MassIVE; Q96BV0; -.
DR PaxDb; Q96BV0; -.
DR PeptideAtlas; Q96BV0; -.
DR PRIDE; Q96BV0; -.
DR ProteomicsDB; 76118; -.
DR Antibodypedia; 32879; 79 antibodies from 13 providers.
DR DNASU; 285971; -.
DR Ensembl; ENST00000329630.10; ENSP00000330838.5; ENSG00000196456.13.
DR GeneID; 285971; -.
DR KEGG; hsa:285971; -.
DR MANE-Select; ENST00000329630.10; ENSP00000330838.5; NM_173680.4; NP_775951.2.
DR UCSC; uc003whf.2; human.
DR CTD; 285971; -.
DR DisGeNET; 285971; -.
DR GeneCards; ZNF775; -.
DR HGNC; HGNC:28501; ZNF775.
DR HPA; ENSG00000196456; Low tissue specificity.
DR neXtProt; NX_Q96BV0; -.
DR OpenTargets; ENSG00000196456; -.
DR PharmGKB; PA162410371; -.
DR VEuPathDB; HostDB:ENSG00000196456; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000154411; -.
DR HOGENOM; CLU_002678_78_0_1; -.
DR InParanoid; Q96BV0; -.
DR OMA; PAIHSCP; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q96BV0; -.
DR TreeFam; TF350922; -.
DR PathwayCommons; Q96BV0; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q96BV0; -.
DR BioGRID-ORCS; 285971; 11 hits in 1097 CRISPR screens.
DR ChiTaRS; ZNF775; human.
DR GenomeRNAi; 285971; -.
DR Pharos; Q96BV0; Tdark.
DR PRO; PR:Q96BV0; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q96BV0; protein.
DR Bgee; ENSG00000196456; Expressed in tendon of biceps brachii and 153 other tissues.
DR ExpressionAtlas; Q96BV0; baseline and differential.
DR Genevisible; Q96BV0; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 11.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE 1: Evidence at protein level;
KW DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Ubl conjugation; Zinc;
KW Zinc-finger.
FT CHAIN 1..537
FT /note="Zinc finger protein 775"
FT /id="PRO_0000280441"
FT ZN_FING 107..129
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 135..157
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 163..185
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 191..213
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 281..303
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 309..331
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 337..359
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 366..388
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 446..468
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 474..496
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 502..524
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 39..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 386..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 533
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VARIANT 428
FT /note="T -> A (in dbSNP:rs13225910)"
FT /id="VAR_059937"
SQ SEQUENCE 537 AA; 59752 MW; BC34D5E1E3ED0BB5 CRC64;
MESGLAGNGT GAGLVMKVKQ EKPERLLQTL APQAMLVEKD KENIFQQHRG LPPRQTMGRP
RALGGQEESG SPRWAPPTEQ DAGLAGRAPG SASGPLSPSL SSGEGHFVCL DCGKRFSWWS
SLKIHQRTHT GEKPYLCGKC GKSFSQKPNL ARHQRHHTGE RPFCCPECAR RFSQKQHLLK
HQKTHSRPAT HSCPECERCF RHQVGLRIHQ RAHARDRQGS RAGLHELIQD AAARRACRLQ
PGPPRGRPEW AWLGLCQGWW GQPGARAAVS GPEGPGEPRQ FICNECGKSF TWWSSLNIHQ
RIHTGERPYA CPECGRRFSQ KPNLTRHLRN HTGERPHPCP HCGRGFRQKQ HLLKHLRTHL
PGAQAAPCPS CGKSCRSRAA LRAHQRAHAV AEPAVPAGEP GDQPQAEAIP GLAARPRSSQ
RSPGARDTLW GRGQAGLAGP GEPRQFICNE CGKSFSWWSA LTIHQRIHTG ERPYPCPECG
RRFSQKPNLT RHRRNHTGER PYLCPACGRG FSQKQHLLKH QRVHRAAPAC SPKEEAR
