ZN775_MOUSE
ID ZN775_MOUSE Reviewed; 538 AA.
AC Q8BI73;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Zinc finger protein 775;
GN Name=Znf775; Synonyms=Zfp775;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Egg, Head, and Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK048054; BAC33226.1; -; mRNA.
DR EMBL; AK167452; BAE39538.1; -; mRNA.
DR EMBL; AK163249; BAE37256.1; -; mRNA.
DR CCDS; CCDS20107.1; -.
DR RefSeq; NP_775605.1; NM_173429.2.
DR RefSeq; XP_006506141.1; XM_006506078.3.
DR AlphaFoldDB; Q8BI73; -.
DR SMR; Q8BI73; -.
DR STRING; 10090.ENSMUSP00000056290; -.
DR PhosphoSitePlus; Q8BI73; -.
DR MaxQB; Q8BI73; -.
DR PaxDb; Q8BI73; -.
DR PRIDE; Q8BI73; -.
DR ProteomicsDB; 275093; -.
DR DNASU; 243372; -.
DR Ensembl; ENSMUST00000061720; ENSMUSP00000056290; ENSMUSG00000007216.
DR Ensembl; ENSMUST00000204095; ENSMUSP00000145192; ENSMUSG00000007216.
DR GeneID; 243372; -.
DR KEGG; mmu:243372; -.
DR UCSC; uc009bvb.1; mouse.
DR CTD; 243372; -.
DR MGI; MGI:2683557; Zfp775.
DR VEuPathDB; HostDB:ENSMUSG00000007216; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT01050000244892; -.
DR HOGENOM; CLU_002678_78_0_1; -.
DR InParanoid; Q8BI73; -.
DR OMA; PAIHSCP; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8BI73; -.
DR TreeFam; TF350922; -.
DR Reactome; R-MMU-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 243372; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Zfp775; mouse.
DR PRO; PR:Q8BI73; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q8BI73; protein.
DR Bgee; ENSMUSG00000007216; Expressed in cleaving embryo and 204 other tissues.
DR ExpressionAtlas; Q8BI73; baseline and differential.
DR Genevisible; Q8BI73; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 11.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..538
FT /note="Zinc finger protein 775"
FT /id="PRO_0000280442"
FT ZN_FING 104..126
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 132..154
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 160..182
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 188..210
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 279..301
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 307..329
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 335..357
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 364..386
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 446..468
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 474..496
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 502..524
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 35..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 538 AA; 60720 MW; EB8B9E3A0880DC80 CRC64;
MESGLAGSIS GDGLARIKQE KPEWLLQTVA SQATEKDKEN IFQQQSGLPP CQTMGRPRAL
GSQEETGGTR WAPLPEQDAP LAARVPGTAP GPLSPSLSAG GGHFVCVDCG KRFSWWSSLK
IHQRTHTGEK PYLCGKCGKS FSQKPNLVRH QRHHTGERPF CCPECTRRFS QKQHLLKHQK
THSRPATHTC PECERCFRHQ VGLRIHQRAH ARNRLGARVN LHEMFRYAAA RRWSCRLRPG
SPRGHPEWVW LGLCRSWWGQ HGVRTTAHSR LGPSEQRQFI CNDCGKSFTW WSSLNIHQRI
HTGERPYACP ECGRCFSQKP NLTRHLRNHT GERPHPCSHC GRSFRQKQHL LKHLRTHLPG
AQAARCTSCG QSCPSRAALR AHQRVHTAAE LLRSQSAVRD GVPGSESQAE IAQSVVVKPQ
GPQGAKEVLC GQECETLAVP SEQRQFICNE CGKSFSWWSA LTIHQRIHTG ERPYACPDCG
RCFSQKPNLT RHRRNHTGER PYLCTACGRG FRQKQHLLKH QRVHRGTQAP HPGPEEEL
