ZN778_HUMAN
ID ZN778_HUMAN Reviewed; 729 AA.
AC Q96MU6; Q08AG0;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 3.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Zinc finger protein 778;
GN Name=ZNF778;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- INTERACTION:
CC Q96MU6; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-10291463, EBI-10172290;
CC Q96MU6-2; Q6BCY4-2: CYB5R2; NbExp=3; IntAct=EBI-14242669, EBI-12102608;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96MU6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96MU6-2; Sequence=VSP_040338, VSP_040339;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB71183.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK056437; BAB71183.1; ALT_FRAME; mRNA.
DR EMBL; AC009113; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC125192; AAI25193.3; -; mRNA.
DR CCDS; CCDS45550.1; -. [Q96MU6-1]
DR RefSeq; NP_872337.2; NM_182531.3. [Q96MU6-1]
DR RefSeq; XP_016878504.1; XM_017023015.1. [Q96MU6-2]
DR AlphaFoldDB; Q96MU6; -.
DR SMR; Q96MU6; -.
DR BioGRID; 128247; 17.
DR IntAct; Q96MU6; 4.
DR MINT; Q96MU6; -.
DR STRING; 9606.ENSP00000405289; -.
DR iPTMnet; Q96MU6; -.
DR PhosphoSitePlus; Q96MU6; -.
DR SwissPalm; Q96MU6; -.
DR BioMuta; ZNF778; -.
DR DMDM; 317373490; -.
DR jPOST; Q96MU6; -.
DR MassIVE; Q96MU6; -.
DR MaxQB; Q96MU6; -.
DR PaxDb; Q96MU6; -.
DR PeptideAtlas; Q96MU6; -.
DR PRIDE; Q96MU6; -.
DR ProteomicsDB; 77411; -. [Q96MU6-1]
DR ProteomicsDB; 77412; -. [Q96MU6-2]
DR TopDownProteomics; Q96MU6-1; -. [Q96MU6-1]
DR Antibodypedia; 30845; 62 antibodies from 13 providers.
DR DNASU; 197320; -.
DR Ensembl; ENST00000306502.6; ENSP00000305203.6; ENSG00000170100.14. [Q96MU6-2]
DR Ensembl; ENST00000620195.4; ENSP00000481538.1; ENSG00000170100.14. [Q96MU6-1]
DR GeneID; 197320; -.
DR KEGG; hsa:197320; -.
DR UCSC; uc002fmv.4; human. [Q96MU6-1]
DR CTD; 197320; -.
DR DisGeNET; 197320; -.
DR GeneCards; ZNF778; -.
DR HGNC; HGNC:26479; ZNF778.
DR HPA; ENSG00000170100; Low tissue specificity.
DR neXtProt; NX_Q96MU6; -.
DR OpenTargets; ENSG00000170100; -.
DR PharmGKB; PA162410400; -.
DR VEuPathDB; HostDB:ENSG00000170100; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162638; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q96MU6; -.
DR PhylomeDB; Q96MU6; -.
DR TreeFam; TF342172; -.
DR PathwayCommons; Q96MU6; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q96MU6; -.
DR BioGRID-ORCS; 197320; 20 hits in 1099 CRISPR screens.
DR ChiTaRS; ZNF778; human.
DR GenomeRNAi; 197320; -.
DR Pharos; Q96MU6; Tdark.
DR PRO; PR:Q96MU6; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q96MU6; protein.
DR Bgee; ENSG00000170100; Expressed in sural nerve and 135 other tissues.
DR ExpressionAtlas; Q96MU6; baseline and differential.
DR Genevisible; Q96MU6; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 13.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 18.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 9.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 18.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..729
FT /note="Zinc finger protein 778"
FT /id="PRO_0000263109"
FT DOMAIN 42..110
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 115..140
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 253..275
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 279..303
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 309..331
FT /note="C2H2-type 4; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 337..359
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 365..387
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 393..415
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 421..443
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 449..471
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 477..499
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 505..527
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 533..555
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 561..583
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 589..611
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 617..639
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 645..667
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 673..695
FT /note="C2H2-type 17; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 701..723
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 1..70
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_040338"
FT VAR_SEQ 81
FT /note="V -> VGHHLFQPSVIYWLEQEEELRAGRRAVLQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_040339"
FT VARIANT 683
FT /note="N -> D (in dbSNP:rs55974122)"
FT /id="VAR_061966"
FT CONFLICT 164
FT /note="K -> T (in Ref. 1; BAB71183)"
FT /evidence="ECO:0000305"
FT CONFLICT 393
FT /note="Y -> H (in Ref. 1; BAB71183)"
FT /evidence="ECO:0000305"
FT CONFLICT 534
FT /note="I -> T (in Ref. 1; BAB71183)"
FT /evidence="ECO:0000305"
FT CONFLICT 553
FT /note="Q -> H (in Ref. 1; BAB71183)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 729 AA; 81964 MW; 86E9F02F0A19FC68 CRC64;
MAAPDLAHGG HVSRDSVCLH EEQTQAAGMV AGWLINCYQD AVTFDDVAVD FTQEEWTLLD
PSQRDLYRDV MLENYENLAS VEWRLKTKGP ALRQDRSWFR ASNETQTARS HNGGQLCDRT
QCGEAFSEHS GLSTHVRTQN TGDSCVSNHY ERDFFIPCQK TLFKIGEQFS VLGQCGKAFS
STPNVVSQQA CTRDRSLDYS SCGEVFLNQS YLQARAGSHN GEETWKWKPC GKALTHSMGC
ATPVEMHAVR NPHVCRECGK AFRYTAYLTG RVQVHPGEKP CELEECGKAS PVSSSLTQHV
RIHAAEKPCE CKECGKAFTG LSGLSKHVQT DPGQKPYECK DCGKACGGFY LLNEHGKTHT
REKPFACVVC GKYFRNSSCL NNHVRIHTGI KPYTCSYCGK AFTVRCGLTR HVRTHTGEKP
YTCKDCGKAF CTSSGLTEHV RTHTGEKPYE CKDCGKSFTV SSSLTEHARI HTGEKPYECK
QCGKAFTGRS GLTKHMRTHT GEKPYECKDC GKAYNRVYLL NEHVKTHTEE KPFICTVCRK
SFRNSSCLNK HIQIHTGIKP YECKDCGKTF TVSSSLTEHI RTHTGEKPYE CKVCGKAFTT
SSHLIVHIRT HTGEKPYICK ECGKAFASSS HLIEHRRTHT GEKPYICNEC GKAFRASSHL
HKHGRIHTGQ KPYKCKECGK AYNRFYLLKE HLKTYTEEQV FVCKDCGKSF KNSSCLNHHT
QIHTDEKPF
