ZN781_HUMAN
ID ZN781_HUMAN Reviewed; 355 AA.
AC Q8N8C0; Q2VPJ8;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Zinc finger protein 781;
GN Name=ZNF781;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N8C0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N8C0-2; Sequence=VSP_026560;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK097019; BAC04927.1; -; mRNA.
DR EMBL; BC108687; AAI08688.1; -; mRNA.
DR RefSeq; NP_689818.2; NM_152605.3. [Q8N8C0-2]
DR AlphaFoldDB; Q8N8C0; -.
DR SMR; Q8N8C0; -.
DR IntAct; Q8N8C0; 1.
DR STRING; 9606.ENSP00000351391; -.
DR iPTMnet; Q8N8C0; -.
DR PhosphoSitePlus; Q8N8C0; -.
DR BioMuta; ZNF781; -.
DR DMDM; 74760005; -.
DR jPOST; Q8N8C0; -.
DR MassIVE; Q8N8C0; -.
DR PaxDb; Q8N8C0; -.
DR PeptideAtlas; Q8N8C0; -.
DR PRIDE; Q8N8C0; -.
DR ProteomicsDB; 72398; -. [Q8N8C0-1]
DR ProteomicsDB; 72399; -. [Q8N8C0-2]
DR Antibodypedia; 29946; 36 antibodies from 16 providers.
DR DNASU; 163115; -.
DR Ensembl; ENST00000358582.9; ENSP00000351391.2; ENSG00000196381.11. [Q8N8C0-2]
DR Ensembl; ENST00000590008.5; ENSP00000466370.2; ENSG00000196381.11. [Q8N8C0-2]
DR GeneID; 163115; -.
DR UCSC; uc002ogy.3; human. [Q8N8C0-1]
DR CTD; 163115; -.
DR GeneCards; ZNF781; -.
DR HGNC; HGNC:26745; ZNF781.
DR HPA; ENSG00000196381; Low tissue specificity.
DR neXtProt; NX_Q8N8C0; -.
DR OpenTargets; ENSG00000196381; -.
DR PharmGKB; PA162410427; -.
DR VEuPathDB; HostDB:ENSG00000196381; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164604; -.
DR HOGENOM; CLU_073612_0_0_1; -.
DR InParanoid; Q8N8C0; -.
DR OMA; HMSVRNV; -.
DR PhylomeDB; Q8N8C0; -.
DR TreeFam; TF340562; -.
DR PathwayCommons; Q8N8C0; -.
DR SignaLink; Q8N8C0; -.
DR BioGRID-ORCS; 163115; 14 hits in 1045 CRISPR screens.
DR ChiTaRS; ZNF781; human.
DR GenomeRNAi; 163115; -.
DR Pharos; Q8N8C0; Tdark.
DR PRO; PR:Q8N8C0; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8N8C0; protein.
DR Bgee; ENSG00000196381; Expressed in left testis and 122 other tissues.
DR ExpressionAtlas; Q8N8C0; baseline and differential.
DR Genevisible; Q8N8C0; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR039938; ZNF781.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR14947; PTHR14947; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..355
FT /note="Zinc finger protein 781"
FT /id="PRO_0000293693"
FT ZN_FING 33..55
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 61..83
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 89..111
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 117..133
FT /note="C2H2-type 4; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 328..355
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_026560"
SQ SEQUENCE 355 AA; 41526 MW; 728D243A9F9F0DB1 CRC64;
MQRNAMYLKN VAETACNFQL TQYQISHANQ KPYECQICGK PFRKRAHLTQ HNRIHTGGKP
YECKECGKVF ICCSTLIQHK RTHTSEKPYE CLECRKTFRR SAHLIRHQRI HTGEKPYKCK
QCWKAFASVS DLIDIGKFTL MRDFTNVQNV GRHLTIAQLL FSIREFTLVR SPLNVRNVAK
HSIIAQHLLN TRELILMRNL MNVRNVKRLL GKVHILLNIK EFILVRNHMS VSNVGRLSLV
FLILIDIREF TLVKNPMNVK NVVELLTIVQ LLFNTREFTL VRRLMNISSV GRFLSPVQHL
FNIREHILMK NLMNVSNARR PSSIMHILFD IKEFILVRNL INVSNVGRPL LLFLI
