ZN782_HUMAN
ID ZN782_HUMAN Reviewed; 699 AA.
AC Q6ZMW2; B2RNR0;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Zinc finger protein 782;
GN Name=ZNF782;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK131468; BAD18613.1; -; mRNA.
DR EMBL; CH471174; EAW92667.1; -; Genomic_DNA.
DR EMBL; BC137073; AAI37074.1; -; mRNA.
DR CCDS; CCDS35075.1; -.
DR RefSeq; NP_001001662.1; NM_001001662.2.
DR RefSeq; NP_001333920.1; NM_001346991.1.
DR RefSeq; XP_011516617.1; XM_011518315.2.
DR RefSeq; XP_011516620.1; XM_011518318.2.
DR AlphaFoldDB; Q6ZMW2; -.
DR SMR; Q6ZMW2; -.
DR BioGRID; 127682; 37.
DR STRING; 9606.ENSP00000419397; -.
DR iPTMnet; Q6ZMW2; -.
DR PhosphoSitePlus; Q6ZMW2; -.
DR BioMuta; ZNF782; -.
DR DMDM; 74758686; -.
DR jPOST; Q6ZMW2; -.
DR MassIVE; Q6ZMW2; -.
DR MaxQB; Q6ZMW2; -.
DR PaxDb; Q6ZMW2; -.
DR PeptideAtlas; Q6ZMW2; -.
DR PRIDE; Q6ZMW2; -.
DR ProteomicsDB; 67928; -.
DR Antibodypedia; 1843; 74 antibodies from 15 providers.
DR DNASU; 158431; -.
DR Ensembl; ENST00000481138.6; ENSP00000419397.1; ENSG00000196597.13.
DR Ensembl; ENST00000535338.5; ENSP00000440624.2; ENSG00000196597.13.
DR GeneID; 158431; -.
DR KEGG; hsa:158431; -.
DR MANE-Select; ENST00000481138.6; ENSP00000419397.1; NM_001001662.3; NP_001001662.1.
DR UCSC; uc004awp.2; human.
DR CTD; 158431; -.
DR GeneCards; ZNF782; -.
DR HGNC; HGNC:33110; ZNF782.
DR HPA; ENSG00000196597; Low tissue specificity.
DR neXtProt; NX_Q6ZMW2; -.
DR OpenTargets; ENSG00000196597; -.
DR PharmGKB; PA162410440; -.
DR VEuPathDB; HostDB:ENSG00000196597; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163051; -.
DR HOGENOM; CLU_002678_17_1_1; -.
DR InParanoid; Q6ZMW2; -.
DR OMA; TSCLIQP; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q6ZMW2; -.
DR TreeFam; TF350803; -.
DR PathwayCommons; Q6ZMW2; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 158431; 14 hits in 1104 CRISPR screens.
DR ChiTaRS; ZNF782; human.
DR GenomeRNAi; 158431; -.
DR Pharos; Q6ZMW2; Tdark.
DR PRO; PR:Q6ZMW2; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q6ZMW2; protein.
DR Bgee; ENSG00000196597; Expressed in sural nerve and 120 other tissues.
DR ExpressionAtlas; Q6ZMW2; baseline and differential.
DR Genevisible; Q6ZMW2; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 11.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..699
FT /note="Zinc finger protein 782"
FT /id="PRO_0000263075"
FT DOMAIN 8..79
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 279..307
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 316..332
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 337..360
FT /note="C2H2-type 3; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 366..388
FT /note="C2H2-type 4; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 394..416
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 422..444
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 450..472
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 478..500
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 506..528
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 534..556
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 562..584
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 590..612
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 618..640
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 646..668
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 674..696
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 75..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 130
FT /note="R -> P (in dbSNP:rs7870376)"
FT /id="VAR_029578"
FT VARIANT 165
FT /note="R -> H (in dbSNP:rs4645656)"
FT /id="VAR_029579"
FT VARIANT 246
FT /note="N -> S (in dbSNP:rs34763627)"
FT /id="VAR_052901"
FT VARIANT 289
FT /note="T -> A (in dbSNP:rs35403084)"
FT /id="VAR_052902"
SQ SEQUENCE 699 AA; 80904 MW; 8519D1CD3EEC15E2 CRC64;
MNTFQASVSF QDVTVEFSQE EWQHMGPVER TLYRDVMLEN YSHLVSVGYC FTKPELIFTL
EQGEDPWLLE KEKGFLSRNS PEDSQPDEIS EKSPENQGKH LLQVLFTNKL LTTEQEISGK
PHNRDINIFR ARMMPCKCDI AGSACQGLSL MAPHCQYSKE KAHERNVCDK WLISIKDGRT
NTQEKSFAYS KIVKTLHHKE EVIQHQTIQT LGQDFEYNES RKAFLEKAAL VTSNSTHPKG
KSYNFNKFGE NKYDKSTFII PQNMNPEKSH YEFNDTGNCF CRITHKTLTG GKSFSQKSHI
REHHRVHIGV KPFEYGKSFN RNSTLPVHQR THATDKYSDY HPCTETFSYQ STFSVHQKVH
IRAKPYEYNE CGKSCSMNSH LIWPQKSHTG EKPYECPECG KAFSEKSRLR KHQRTHTGEK
PYKCDGCDKA FSAKSGLRIH QRTHTGEKPF ECHECGKSFN YKSILIVHQR THTGEKPFEC
NECGKSFSHM SGLRNHRRTH TGERPYKCDE CGKAFKLKSG LRKHHRTHTG EKPYKCNQCG
KAFGQKSQLR GHHRIHTGEK PYKCNHCGEA FSQKSNLRVH HRTHTGEKPY QCEECGKTFR
QKSNLRGHQR THTGEKPYEC NECGKAFSEK SVLRKHQRTH TGEKPYNCNQ CGEAFSQKSN
LRVHQRTHTG EKPYKCDKCG RTFSQKSSLR EHQKAHPGD
