ZN786_HUMAN
ID ZN786_HUMAN Reviewed; 782 AA.
AC Q8N393; A1A568; B4DMI1;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Zinc finger protein 786;
GN Name=ZNF786;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Melanoma;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q8N393; O95273: CCNDBP1; NbExp=3; IntAct=EBI-10265203, EBI-748961;
CC Q8N393; A8MQ03: CYSRT1; NbExp=4; IntAct=EBI-10265203, EBI-3867333;
CC Q8N393; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-10265203, EBI-11959885;
CC Q8N393; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-10265203, EBI-11749135;
CC Q8N393; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-10265203, EBI-10172290;
CC Q8N393; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-10265203, EBI-10171774;
CC Q8N393; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-10265203, EBI-14065470;
CC Q8N393; Q99750: MDFI; NbExp=3; IntAct=EBI-10265203, EBI-724076;
CC Q8N393; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-10265203, EBI-22310682;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N393-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N393-2; Sequence=VSP_055971;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK297472; BAG59893.1; -; mRNA.
DR EMBL; AL834510; CAD39166.1; -; mRNA.
DR EMBL; AACC02000041; EAL24426.1; -; Genomic_DNA.
DR EMBL; AC073422; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC128392; AAI28393.1; -; mRNA.
DR CCDS; CCDS47738.1; -. [Q8N393-1]
DR RefSeq; NP_689624.2; NM_152411.3. [Q8N393-1]
DR AlphaFoldDB; Q8N393; -.
DR SMR; Q8N393; -.
DR BioGRID; 126445; 22.
DR IntAct; Q8N393; 18.
DR STRING; 9606.ENSP00000417470; -.
DR GlyGen; Q8N393; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q8N393; -.
DR PhosphoSitePlus; Q8N393; -.
DR BioMuta; ZNF786; -.
DR DMDM; 296453058; -.
DR EPD; Q8N393; -.
DR MassIVE; Q8N393; -.
DR PaxDb; Q8N393; -.
DR PeptideAtlas; Q8N393; -.
DR PRIDE; Q8N393; -.
DR ProteomicsDB; 4612; -.
DR ProteomicsDB; 71781; -. [Q8N393-1]
DR Antibodypedia; 32776; 128 antibodies from 23 providers.
DR DNASU; 136051; -.
DR Ensembl; ENST00000491431.2; ENSP00000417470.1; ENSG00000197362.15. [Q8N393-1]
DR GeneID; 136051; -.
DR KEGG; hsa:136051; -.
DR MANE-Select; ENST00000491431.2; ENSP00000417470.1; NM_152411.4; NP_689624.2.
DR UCSC; uc003wfh.3; human. [Q8N393-1]
DR CTD; 136051; -.
DR DisGeNET; 136051; -.
DR GeneCards; ZNF786; -.
DR HGNC; HGNC:21806; ZNF786.
DR HPA; ENSG00000197362; Low tissue specificity.
DR neXtProt; NX_Q8N393; -.
DR OpenTargets; ENSG00000197362; -.
DR PharmGKB; PA162410468; -.
DR VEuPathDB; HostDB:ENSG00000197362; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162604; -.
DR HOGENOM; CLU_002678_17_1_1; -.
DR InParanoid; Q8N393; -.
DR OMA; QRIHRPD; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8N393; -.
DR TreeFam; TF326846; -.
DR PathwayCommons; Q8N393; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q8N393; -.
DR BioGRID-ORCS; 136051; 16 hits in 1102 CRISPR screens.
DR ChiTaRS; ZNF786; human.
DR GenomeRNAi; 136051; -.
DR Pharos; Q8N393; Tdark.
DR PRO; PR:Q8N393; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8N393; protein.
DR Bgee; ENSG00000197362; Expressed in upper arm skin and 172 other tissues.
DR ExpressionAtlas; Q8N393; baseline and differential.
DR Genevisible; Q8N393; HS.
DR GO; GO:0005634; C:nucleus; IDA:LIFEdb.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 11.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 15.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 9.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 15.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..782
FT /note="Zinc finger protein 786"
FT /id="PRO_0000293694"
FT DOMAIN 9..80
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 192..209
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 240..262
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 369..391
FT /note="C2H2-type 3; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 397..419
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 425..447
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 453..475
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 481..503
FT /note="C2H2-type 7; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 509..531
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 537..559
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 565..587
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 593..615
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 621..643
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 649..670
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 676..698
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 704..726
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 732..754
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 141..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 285..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..358
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..37
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055971"
FT CONFLICT 503
FT /note="H -> Q (in Ref. 2; CAD39166)"
FT /evidence="ECO:0000305"
FT CONFLICT 714
FT /note="R -> W (in Ref. 2; CAD39166)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 782 AA; 89815 MW; 9BDB1B88B5759F76 CRC64;
MAEPPRLPLT FEDVAIYFSE QEWQDLEAWQ KELYKHVMRS NYETLVSLDD GLPKPELISW
IEHGGEPFRK WRESQKSGNI ICSSVDMHFD PGFEEQLFWG SQQAMNSGKT KSHFQLDPES
QCSFGSFVSF RPDQGITLGS PQRHDARAPP PLACGPSEST LKEGIPGPRN LDLPGLWDVP
AWESTQHPWP VCGESCWENN HLVMHQRGHS KDRTRRAWEK FNKRAETQMP WSSPRVQRHF
RCGVCGKSFR RKLCLLRHLA AHTGRGPFRN ADGEMCFRHE LTHPSHRLPQ QGEKPAQCTP
CGKRSLPVDS TQARRCQHSR EGPASWREGR GASSSVHSGQ KPGSRLPQEG NSHQEGDTEA
LQHGAEGPCS CSECGERSPM SARLASPCRA HTGEKPFQCA HCTKRFRLRR LLQVHQHAHG
GERPFSCRKC GKGFAKQCKL TEHIRVHSGE KPFRCAKCGR NFRQRGQLLR HQRLHTDEKP
FQCPECGLSF RLESMLRAHR LRHGGERPFS CSECGRGFTH QCKLREHLRV HSGERPFQCL
KCDKRFRLKG ILKAHQHTHS KERPFSCGEC GKGFTRQSKL TEHLRVHSGE RPFQCPECNR
SFRLKGQLLS HQRLHTGERP FQCPECDKRY RVKADMKAHQ LLHSGEMPFS CECGKGFVKH
SKLIEHIRTH TGEKPFQCPK CDKSFRLKAQ LLSHQGLHTG ERPFHCPECD KNFRERGHML
RHQRIHRPER PFACGDCGKG FIYKSKLAEH IRVHTKSCPA PNELDIKKRL SQLFAMIEAD
WS
