ZN786_MOUSE
ID ZN786_MOUSE Reviewed; 777 AA.
AC Q8BV42;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Zinc finger protein 786;
GN Name=Znf786; Synonyms=Zfp786;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK080438; BAC37916.1; -; mRNA.
DR CCDS; CCDS20098.1; -.
DR RefSeq; NP_808550.1; NM_177882.4.
DR AlphaFoldDB; Q8BV42; -.
DR SMR; Q8BV42; -.
DR STRING; 10090.ENSMUSP00000057495; -.
DR iPTMnet; Q8BV42; -.
DR PhosphoSitePlus; Q8BV42; -.
DR PaxDb; Q8BV42; -.
DR PRIDE; Q8BV42; -.
DR Antibodypedia; 32776; 128 antibodies from 23 providers.
DR DNASU; 330301; -.
DR Ensembl; ENSMUST00000058844; ENSMUSP00000057495; ENSMUSG00000051499.
DR GeneID; 330301; -.
DR KEGG; mmu:330301; -.
DR UCSC; uc009btg.1; mouse.
DR CTD; 330301; -.
DR MGI; MGI:3026883; Zfp786.
DR VEuPathDB; HostDB:ENSMUSG00000051499; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162604; -.
DR HOGENOM; CLU_002678_41_1_1; -.
DR InParanoid; Q8BV42; -.
DR OMA; QRIHRPD; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8BV42; -.
DR TreeFam; TF326846; -.
DR Reactome; R-MMU-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 330301; 0 hits in 71 CRISPR screens.
DR PRO; PR:Q8BV42; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q8BV42; protein.
DR Bgee; ENSMUSG00000051499; Expressed in spermatid and 52 other tissues.
DR ExpressionAtlas; Q8BV42; baseline and differential.
DR Genevisible; Q8BV42; MM.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 10.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..777
FT /note="Zinc finger protein 786"
FT /id="PRO_0000293695"
FT DOMAIN 9..80
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 194..216
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 240..262
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 268..291
FT /note="C2H2-type 3; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 420..442
FT /note="C2H2-type 4; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 448..470
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 476..498
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 504..526
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 532..554
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 560..582
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 588..610
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 616..638
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 644..665
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 671..693
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 699..721
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 727..749
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ SEQUENCE 777 AA; 89484 MW; 179650895B977E9F CRC64;
MAGPARFPLT FEDVAIYFSE QEWQHLEAWQ KELYKQVMRT NYETLISLDN GLPKPELISW
IELGRELFGS WGEKKKPDKE THCSIDDVHV HLAIEEQLLE SSQRAVKSEV TCHSQLNPLE
SRHSFGLAVG ERVDASLRHD QGISLVNAQT RCGEAVVSVV HSSSEAAQRK VLSSHRTLAL
PGLQRVSSWQ STQNSCPVCR ENSWEKNHLV KQQKGHSKSR SYRVWKKFSR QADAKQPWSI
SCLGCGKSFR LKQYLVRHLD IHTRKRPPQC PKCKMCFHHE RTLFSHHLKN SSSQHPTCDT
SFRTDSSVDL CQQIQERPAF WREDTNVPSR QKPGPSLDCE DCCHMGSKLK GLQCGCILGE
DRPHSHTEYG NCFLSQSKQA GLCRTHTGEK ASQCPESNKR LCLRGLQNVH QHGLRGEKPV
FCRKCGQGFT KHCGLTEHTR ILSGEKSFWC AQCGRNFSQK GQLLRHQRLH LEEKPFQCTM
CELRFHLKSR LRAHQLQHGG ERPFSCSECG RAFTHQCKLR EHLRVHSGER PFQCPECHKS
FRLKGVLKAH QRIHSKERPF SCGECGKGFI RQSKLTEHFR VHSGERPFQC PECDRRFRLK
GQLLSHQRLH TGERPFQCPE CGKSYRVKAD MKAHQLLHGG QMPFSCQCGK GFAKQSKLVE
HMRTHTGEKP FQCPKCDKSF RLKAQLLSHQ GLHTGERPFH CPECDKNFRE KGHMLRHQRI
HRPERPFACG DCGKGFIYKS KLAEHIRVHT KACQVPREPD IKKRLSQLFA MIEADWS
