ZN787_MOUSE
ID ZN787_MOUSE Reviewed; 381 AA.
AC Q8BIF9; B9EHE2;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 3.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Zinc finger protein 787;
GN Name=Znf787; Synonyms=Zfp787;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC36810.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK077458; BAC36810.1; ALT_FRAME; mRNA.
DR EMBL; CH466627; EDL31307.1; -; Genomic_DNA.
DR EMBL; BC137753; AAI37754.1; -; mRNA.
DR CCDS; CCDS20769.1; -.
DR RefSeq; NP_001013030.1; NM_001013012.1.
DR RefSeq; XP_006540376.1; XM_006540313.3.
DR AlphaFoldDB; Q8BIF9; -.
DR SMR; Q8BIF9; -.
DR BioGRID; 211946; 26.
DR IntAct; Q8BIF9; 1.
DR STRING; 10090.ENSMUSP00000092468; -.
DR iPTMnet; Q8BIF9; -.
DR PhosphoSitePlus; Q8BIF9; -.
DR EPD; Q8BIF9; -.
DR MaxQB; Q8BIF9; -.
DR PaxDb; Q8BIF9; -.
DR PeptideAtlas; Q8BIF9; -.
DR PRIDE; Q8BIF9; -.
DR ProteomicsDB; 299602; -.
DR Antibodypedia; 33179; 88 antibodies from 16 providers.
DR DNASU; 67109; -.
DR Ensembl; ENSMUST00000094870; ENSMUSP00000092468; ENSMUSG00000046792.
DR GeneID; 67109; -.
DR KEGG; mmu:67109; -.
DR UCSC; uc009fap.1; mouse.
DR CTD; 67109; -.
DR MGI; MGI:1914359; Zfp787.
DR VEuPathDB; HostDB:ENSMUSG00000046792; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163064; -.
DR HOGENOM; CLU_002678_19_0_1; -.
DR InParanoid; Q8BIF9; -.
DR OMA; PKPYVCM; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8BIF9; -.
DR TreeFam; TF337689; -.
DR BioGRID-ORCS; 67109; 6 hits in 72 CRISPR screens.
DR ChiTaRS; Zfp787; mouse.
DR PRO; PR:Q8BIF9; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8BIF9; protein.
DR Bgee; ENSMUSG00000046792; Expressed in retinal neural layer and 249 other tissues.
DR ExpressionAtlas; Q8BIF9; baseline and differential.
DR Genevisible; Q8BIF9; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF57667; SSF57667; 5.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 2: Evidence at transcript level;
KW DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1..381
FT /note="Zinc finger protein 787"
FT /id="PRO_0000287607"
FT ZN_FING 66..88
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 94..116
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 122..144
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 150..172
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 178..200
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 280..303
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 317..339
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..65
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 117
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q6DD87"
FT MOD_RES 122
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q6DD87"
FT MOD_RES 132
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6DD87"
FT CROSSLNK 191
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q6DD87"
FT CROSSLNK 211
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q6DD87"
FT CONFLICT 193
FT /note="L -> M (in Ref. 1; BAC36810)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 381 AA; 40477 MW; 06F4C15E90FF8F0F CRC64;
MELREEAWSP GPLDSEDQQM ASHENPVDIL IMDDDDVPSW PPTKLSPPQS APPPGPPPRP
RPPAPYICTE CGKSFSHWSK LTRHQRTHTG ERPNACTDCG KTFSQSSHLV QHRRIHTGEK
PYACSECGKR FSWSSNLMQH QRIHTGEKPY TCPDCGRSFT QSKSLAKHRR SHSGLKPFVC
PRCGRGFSQP KSLARHLRLH PELSGPGVAA KVLAASVRRA KAPEEATAAD GEIAIPVGDG
EGIIVVGPPG DGAAAAAALA GVGTRATGTR SRRAPAPKPY VCMECGKGFG HGAGLLAHQR
AQHGDGLGVA VGEEPAHICV ECGEGFVQGA ALRRHKKIHA VGAPSVCSSC GQSFYRAGGE
DDGEDQSAGA RCAECRGGEA R
