ZN790_HUMAN
ID ZN790_HUMAN Reviewed; 636 AA.
AC Q6PG37;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Zinc finger protein 790;
GN Name=ZNF790;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-301.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AC020928; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC057245; AAH57245.1; -; mRNA.
DR CCDS; CCDS12496.1; -.
DR RefSeq; NP_001229729.1; NM_001242800.1.
DR RefSeq; NP_001229730.1; NM_001242801.1.
DR RefSeq; NP_001229731.1; NM_001242802.1.
DR RefSeq; NP_996777.2; NM_206894.3.
DR RefSeq; XP_005258960.1; XM_005258903.4.
DR RefSeq; XP_011525252.1; XM_011526950.2.
DR AlphaFoldDB; Q6PG37; -.
DR SMR; Q6PG37; -.
DR BioGRID; 132730; 4.
DR IntAct; Q6PG37; 4.
DR STRING; 9606.ENSP00000349161; -.
DR iPTMnet; Q6PG37; -.
DR PhosphoSitePlus; Q6PG37; -.
DR BioMuta; ZNF790; -.
DR DMDM; 296453059; -.
DR jPOST; Q6PG37; -.
DR MassIVE; Q6PG37; -.
DR MaxQB; Q6PG37; -.
DR PaxDb; Q6PG37; -.
DR PeptideAtlas; Q6PG37; -.
DR PRIDE; Q6PG37; -.
DR ProteomicsDB; 67112; -.
DR Antibodypedia; 44747; 28 antibodies from 12 providers.
DR DNASU; 388536; -.
DR Ensembl; ENST00000356725.9; ENSP00000349161.3; ENSG00000197863.9.
DR Ensembl; ENST00000613249.4; ENSP00000480764.1; ENSG00000197863.9.
DR Ensembl; ENST00000614179.4; ENSP00000480834.1; ENSG00000197863.9.
DR Ensembl; ENST00000615484.4; ENSP00000478852.1; ENSG00000197863.9.
DR GeneID; 388536; -.
DR KEGG; hsa:388536; -.
DR MANE-Select; ENST00000356725.9; ENSP00000349161.3; NM_206894.4; NP_996777.2.
DR UCSC; uc002oew.4; human.
DR CTD; 388536; -.
DR GeneCards; ZNF790; -.
DR HGNC; HGNC:33114; ZNF790.
DR HPA; ENSG00000197863; Low tissue specificity.
DR neXtProt; NX_Q6PG37; -.
DR OpenTargets; ENSG00000197863; -.
DR PharmGKB; PA162410507; -.
DR VEuPathDB; HostDB:ENSG00000197863; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163643; -.
DR HOGENOM; CLU_002678_0_9_1; -.
DR InParanoid; Q6PG37; -.
DR OMA; QWKDYGN; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q6PG37; -.
DR TreeFam; TF341817; -.
DR PathwayCommons; Q6PG37; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q6PG37; -.
DR BioGRID-ORCS; 388536; 16 hits in 1090 CRISPR screens.
DR ChiTaRS; ZNF790; human.
DR GenomeRNAi; 388536; -.
DR Pharos; Q6PG37; Tdark.
DR PRO; PR:Q6PG37; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q6PG37; protein.
DR Bgee; ENSG00000197863; Expressed in quadriceps femoris and 105 other tissues.
DR ExpressionAtlas; Q6PG37; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 9.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 9.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..636
FT /note="Zinc finger protein 790"
FT /id="PRO_0000261336"
FT DOMAIN 5..76
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 196..220
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 226..248
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 254..276
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 282..304
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 310..332
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 338..360
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 366..388
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 394..416
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 422..444
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 450..472
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 478..500
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 506..528
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 534..556
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 301
FT /note="Q -> R (in dbSNP:rs3745775)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_060434"
FT VARIANT 486
FT /note="T -> S (in dbSNP:rs4369791)"
FT /id="VAR_057453"
SQ SEQUENCE 636 AA; 74571 MW; E4B6D8DA68E4A051 CRC64;
MAHLMMFRDV AVDFSQEEWE CLDLEQRDLY RDVMLENYSN MVSLGFCIYQ PEAFSLLEKG
KEPWKILRDE TRGPCPDMQS RCQTKKLLPK NGIFEREIAQ LEIMRICKNH SLDCLCFRGD
WEGNTQFQTL QDNQEECFKQ VIRTCEKRPT FNQHTVFNLH QRLNTGDKLN EFKELGKAFI
SGSDHTQHQL IHTSEKFCGD KECGNTFLPD SEVIQYQTVH TVKKTYECKE CGKSFSLRSS
LTGHKRIHTG EKPFKCKDCG KAFRFHSQLS VHKRIHTGEK SYECKECGKA FSCGSDLTRH
QRIHTGEKPY ECNECRKAFS QRSHLIKHQR IHTGEKPYEC KECGKAFTRG SHLTQHQRIH
TGEKSHECKE CGKAFIRGSN LAQHQNVHVG RKPYKCEKCG KAYIWSSHLA RHQRIHTGRK
PYECKQCGKT FTWASYLAQH EKIHNERKSY ECKECGKTFL HGSEFNRHQK IHTGERNYEC
KECGKTFFRG SELNRHQKIH TGKRPYECEE CGKAFLWGSQ LTRHQRMHTG EEPYVCKECG
KSFIWGSQLT RHKKIHTDAE PYGCKKSSHI FSHHSYFTEQ KIHNSANLCE WTDYGNTFSH
ESNFAQHQNI YTFEKSYEFK DFEKAFSSSS HFISLL
