ID   CCA34_ARATH             Reviewed;         370 AA.
AC   Q3ECW2; Q9C6B1;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Cyclin-A3-4;
DE   AltName: Full=G2/mitotic-specific cyclin-A3-4;
DE            Short=CycA3;4;
GN   Name=CYCA3-4; OrderedLocusNames=At1g47230; ORFNames=F8G22.5;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=15208425; DOI=10.1104/pp.104.040436;
RA   Wang G., Kong H., Sun Y., Zhang X., Zhang W., Altman N., dePamphilis C.W.,
RA   Ma H.;
RT   "Genome-wide analysis of the cyclin family in Arabidopsis and comparative
RT   phylogenetic analysis of plant cyclin-like proteins.";
RL   Plant Physiol. 135:1084-1099(2004).
RN   [6]
RP   DEVELOPMENTAL STAGE, AND INTERACTION WITH FZR1; FZR2 AND FZR3.
RX   PubMed=15970679;
RA   Fueloep K., Tarayre S., Kelemen Z., Horvath G., Kevei Z., Nikovics K.,
RA   Bako L., Brown S., Kondorosi A., Kondorosi E.;
RT   "Arabidopsis anaphase-promoting complexes: multiple activators and wide
RT   range of substrates might keep APC perpetually busy.";
RL   Cell Cycle 4:1084-1092(2005).
CC   -!- SUBUNIT: Interacts with FZR2/CCS52A1, FZR1/CCS52A2 and FZR3/CCS52B.
CC       {ECO:0000269|PubMed:15970679}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q3ECW2-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q3ECW2-2; Sequence=VSP_025280;
CC   -!- DEVELOPMENTAL STAGE: Highly expressed in the S and G2 phases and
CC       reduceed levels in the M phase. {ECO:0000269|PubMed:15970679}.
CC   -!- MISCELLANEOUS: [Isoform 2]: May be due to competing acceptor splice
CC       site. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cyclin family. Cyclin AB subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AC079677; AAG52644.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE32140.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE32141.1; -; Genomic_DNA.
DR   EMBL; AK226253; BAE98414.1; -; mRNA.
DR   EMBL; AY087628; AAM65168.1; -; mRNA.
DR   PIR; A96513; A96513.
DR   RefSeq; NP_175156.1; NM_103617.4. [Q3ECW2-2]
DR   RefSeq; NP_973983.1; NM_202254.2. [Q3ECW2-1]
DR   AlphaFoldDB; Q3ECW2; -.
DR   SMR; Q3ECW2; -.
DR   BioGRID; 26351; 27.
DR   IntAct; Q3ECW2; 13.
DR   STRING; 3702.AT1G47230.2; -.
DR   PaxDb; Q3ECW2; -.
DR   PRIDE; Q3ECW2; -.
DR   ProteomicsDB; 223888; -. [Q3ECW2-1]
DR   EnsemblPlants; AT1G47230.1; AT1G47230.1; AT1G47230. [Q3ECW2-2]
DR   EnsemblPlants; AT1G47230.2; AT1G47230.2; AT1G47230. [Q3ECW2-1]
DR   GeneID; 841126; -.
DR   Gramene; AT1G47230.1; AT1G47230.1; AT1G47230. [Q3ECW2-2]
DR   Gramene; AT1G47230.2; AT1G47230.2; AT1G47230. [Q3ECW2-1]
DR   KEGG; ath:AT1G47230; -.
DR   Araport; AT1G47230; -.
DR   TAIR; locus:2036756; AT1G47230.
DR   eggNOG; KOG0654; Eukaryota.
DR   HOGENOM; CLU_020695_2_2_1; -.
DR   InParanoid; Q3ECW2; -.
DR   OMA; EITWEHR; -.
DR   OrthoDB; 993640at2759; -.
DR   PhylomeDB; Q3ECW2; -.
DR   PRO; PR:Q3ECW2; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q3ECW2; baseline and differential.
DR   Genevisible; Q3ECW2; AT.
DR   GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IDA:TAIR.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR   GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR   CDD; cd00043; CYCLIN; 2.
DR   InterPro; IPR039361; Cyclin.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR004367; Cyclin_C-dom.
DR   InterPro; IPR006671; Cyclin_N.
DR   PANTHER; PTHR10177; PTHR10177; 1.
DR   Pfam; PF02984; Cyclin_C; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   PIRSF; PIRSF001771; Cyclin_A_B_D_E; 1.
DR   SMART; SM00385; CYCLIN; 2.
DR   SMART; SM01332; Cyclin_C; 1.
DR   SUPFAM; SSF47954; SSF47954; 2.
DR   PROSITE; PS00292; CYCLINS; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cell cycle; Cell division; Cyclin;
KW   Reference proteome.
FT   CHAIN           1..370
FT                   /note="Cyclin-A3-4"
FT                   /id="PRO_0000287001"
FT   VAR_SEQ         186
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.4"
FT                   /id="VSP_025280"
SQ   SEQUENCE   370 AA;  42317 MW;  2982C98413F3BC69 CRC64;
     MAENQNCARM TRAAAKRKAS SMALDENPVS KKRVVLGELP NMSNVVAVPN QERETLKAKT
     SVNTSKRQMK KALMIPEASV LIESRSVDPQ MCEPFASDIC AYLREMEGKP KHRPLPDYIE
     KVQSDLTPHM RAVLVDWLVE VAEEYKLVSD TLYLTISYVD RFLSVKPINR QKLQLVGVSA
     MLIASRKYEE IGPPKVEDFC YITDNTFTKQ EVVSMEADIL LALQFELGSP TIKTFLRRFT
     RVAQEDFKDS QLQIEFLCCY LSELSMLDYT CVKYLPSLLS ASAVFLARFI IRPKQHPWNQ
     MLEEYTKYKA ADLQVCVGII HDLYLSRRGN TLEAVRNKYK QHKYKCVATM PVSPELPLAF
     FEDITIRGMA