ZN792_HUMAN
ID ZN792_HUMAN Reviewed; 632 AA.
AC Q3KQV3; B4E333; Q495L1; Q495L3; Q8N932;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Zinc finger protein 792;
GN Name=ZNF792;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 74-632, AND VARIANT GLN-177.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-196, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q3KQV3; P29972: AQP1; NbExp=3; IntAct=EBI-10240849, EBI-745213;
CC Q3KQV3; Q9BYV9: BACH2; NbExp=3; IntAct=EBI-10240849, EBI-1642333;
CC Q3KQV3; Q86Z20: CCDC125; NbExp=3; IntAct=EBI-10240849, EBI-11977221;
CC Q3KQV3; P24863: CCNC; NbExp=3; IntAct=EBI-10240849, EBI-395261;
CC Q3KQV3; Q92997: DVL3; NbExp=3; IntAct=EBI-10240849, EBI-739789;
CC Q3KQV3; Q14241: ELOA; NbExp=3; IntAct=EBI-10240849, EBI-742350;
CC Q3KQV3; Q9NQT4: EXOSC5; NbExp=3; IntAct=EBI-10240849, EBI-371876;
CC Q3KQV3; Q3B820: FAM161A; NbExp=3; IntAct=EBI-10240849, EBI-719941;
CC Q3KQV3; P22087: FBL; NbExp=3; IntAct=EBI-10240849, EBI-358318;
CC Q3KQV3; Q5TD97: FHL5; NbExp=3; IntAct=EBI-10240849, EBI-750641;
CC Q3KQV3; O95995: GAS8; NbExp=3; IntAct=EBI-10240849, EBI-1052570;
CC Q3KQV3; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-10240849, EBI-5916454;
CC Q3KQV3; P61978: HNRNPK; NbExp=3; IntAct=EBI-10240849, EBI-304185;
CC Q3KQV3; Q96CX2: KCTD12; NbExp=3; IntAct=EBI-10240849, EBI-358358;
CC Q3KQV3; Q6A162: KRT40; NbExp=3; IntAct=EBI-10240849, EBI-10171697;
CC Q3KQV3; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-10240849, EBI-10172150;
CC Q3KQV3; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-10240849, EBI-12012928;
CC Q3KQV3; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-10240849, EBI-10172290;
CC Q3KQV3; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-10240849, EBI-10171774;
CC Q3KQV3; P60411: KRTAP10-9; NbExp=6; IntAct=EBI-10240849, EBI-10172052;
CC Q3KQV3; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-10240849, EBI-14065470;
CC Q3KQV3; P23508: MCC; NbExp=3; IntAct=EBI-10240849, EBI-307531;
CC Q3KQV3; Q9UJV3-2: MID2; NbExp=6; IntAct=EBI-10240849, EBI-10172526;
CC Q3KQV3; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-10240849, EBI-11522433;
CC Q3KQV3; Q8WWY3: PRPF31; NbExp=3; IntAct=EBI-10240849, EBI-1567797;
CC Q3KQV3; Q15415: RBMY1J; NbExp=3; IntAct=EBI-10240849, EBI-8642021;
CC Q3KQV3; P78317: RNF4; NbExp=3; IntAct=EBI-10240849, EBI-2340927;
CC Q3KQV3; Q9Y2D8: SSX2IP; NbExp=3; IntAct=EBI-10240849, EBI-2212028;
CC Q3KQV3; Q08117-2: TLE5; NbExp=3; IntAct=EBI-10240849, EBI-11741437;
CC Q3KQV3; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-10240849, EBI-725997;
CC Q3KQV3; P42681: TXK; NbExp=3; IntAct=EBI-10240849, EBI-7877438;
CC Q3KQV3; O43167: ZBTB24; NbExp=3; IntAct=EBI-10240849, EBI-744471;
CC Q3KQV3; P15622-3: ZNF250; NbExp=3; IntAct=EBI-10240849, EBI-10177272;
CC Q3KQV3; Q9NSD4: ZNF275; NbExp=3; IntAct=EBI-10240849, EBI-17263125;
CC Q3KQV3; Q9HBT8: ZNF286A; NbExp=3; IntAct=EBI-10240849, EBI-10754950;
CC Q3KQV3; Q9H9D4: ZNF408; NbExp=6; IntAct=EBI-10240849, EBI-347633;
CC Q3KQV3; Q8WTR7: ZNF473; NbExp=5; IntAct=EBI-10240849, EBI-751409;
CC Q3KQV3; Q96MX3: ZNF48; NbExp=3; IntAct=EBI-10240849, EBI-12006434;
CC Q3KQV3; Q6ZNH5: ZNF497; NbExp=3; IntAct=EBI-10240849, EBI-10486136;
CC Q3KQV3; Q8TF50: ZNF526; NbExp=3; IntAct=EBI-10240849, EBI-11035148;
CC Q3KQV3; Q9H707: ZNF552; NbExp=3; IntAct=EBI-10240849, EBI-2555731;
CC Q3KQV3; Q9P0T4: ZNF581; NbExp=3; IntAct=EBI-10240849, EBI-745520;
CC Q3KQV3; Q9UID6: ZNF639; NbExp=3; IntAct=EBI-10240849, EBI-947476;
CC Q3KQV3; Q5T619: ZNF648; NbExp=3; IntAct=EBI-10240849, EBI-11985915;
CC Q3KQV3; Q8N720: ZNF655; NbExp=3; IntAct=EBI-10240849, EBI-625509;
CC Q3KQV3; Q96K58-2: ZNF668; NbExp=3; IntAct=EBI-10240849, EBI-12817597;
CC Q3KQV3; Q9NQZ8: ZNF71; NbExp=3; IntAct=EBI-10240849, EBI-7138235;
CC Q3KQV3; Q3KQV3: ZNF792; NbExp=8; IntAct=EBI-10240849, EBI-10240849;
CC Q3KQV3; Q9Y2P0: ZNF835; NbExp=3; IntAct=EBI-10240849, EBI-5667516;
CC Q3KQV3; Q96EG3: ZNF837; NbExp=3; IntAct=EBI-10240849, EBI-11962574;
CC Q3KQV3; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-10240849, EBI-527853;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI01119.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI01120.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI01121.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK304550; BAG65345.1; -; mRNA.
DR EMBL; AC008555; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC101118; AAI01119.1; ALT_INIT; mRNA.
DR EMBL; BC101119; AAI01120.1; ALT_INIT; mRNA.
DR EMBL; BC101120; AAI01121.1; ALT_INIT; mRNA.
DR CCDS; CCDS12440.2; -.
DR RefSeq; NP_787068.3; NM_175872.4.
DR AlphaFoldDB; Q3KQV3; -.
DR SMR; Q3KQV3; -.
DR BioGRID; 125986; 70.
DR IntAct; Q3KQV3; 50.
DR STRING; 9606.ENSP00000385099; -.
DR iPTMnet; Q3KQV3; -.
DR PhosphoSitePlus; Q3KQV3; -.
DR BioMuta; ZNF792; -.
DR DMDM; 215273919; -.
DR MassIVE; Q3KQV3; -.
DR MaxQB; Q3KQV3; -.
DR PaxDb; Q3KQV3; -.
DR PeptideAtlas; Q3KQV3; -.
DR PRIDE; Q3KQV3; -.
DR ProteomicsDB; 61727; -.
DR Antibodypedia; 29225; 34 antibodies from 11 providers.
DR DNASU; 126375; -.
DR Ensembl; ENST00000404801.2; ENSP00000385099.1; ENSG00000180884.10.
DR GeneID; 126375; -.
DR KEGG; hsa:126375; -.
DR MANE-Select; ENST00000404801.2; ENSP00000385099.1; NM_175872.5; NP_787068.3.
DR UCSC; uc002nxh.1; human.
DR CTD; 126375; -.
DR GeneCards; ZNF792; -.
DR HGNC; HGNC:24751; ZNF792.
DR HPA; ENSG00000180884; Low tissue specificity.
DR neXtProt; NX_Q3KQV3; -.
DR OpenTargets; ENSG00000180884; -.
DR PharmGKB; PA162410535; -.
DR VEuPathDB; HostDB:ENSG00000180884; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162928; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q3KQV3; -.
DR OMA; HPRQKPY; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q3KQV3; -.
DR TreeFam; TF342033; -.
DR PathwayCommons; Q3KQV3; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q3KQV3; -.
DR BioGRID-ORCS; 126375; 12 hits in 1099 CRISPR screens.
DR GenomeRNAi; 126375; -.
DR Pharos; Q3KQV3; Tdark.
DR PRO; PR:Q3KQV3; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q3KQV3; protein.
DR Bgee; ENSG00000180884; Expressed in granulocyte and 116 other tissues.
DR ExpressionAtlas; Q3KQV3; baseline and differential.
DR Genevisible; Q3KQV3; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 11.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..632
FT /note="Zinc finger protein 792"
FT /id="PRO_0000293698"
FT DOMAIN 14..85
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 132..154
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 254..276
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 282..304
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 310..332
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 338..360
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 366..388
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 394..416
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 422..444
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 450..472
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 478..500
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 506..528
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 534..556
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 562..584
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT MOD_RES 196
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VARIANT 177
FT /note="R -> Q (in dbSNP:rs2651079)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_033106"
FT VARIANT 525
FT /note="R -> W (in dbSNP:rs3746244)"
FT /id="VAR_047354"
FT CONFLICT 590
FT /note="M -> T (in Ref. 1; BAG65345)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 632 AA; 71577 MW; 332B2A8E3E0ED873 CRC64;
MAAAALRDPA QGCVTFEDVT IYFSQEEWVL LDEAQRLLYC DVMLENFALI ASLGLISFRS
HIVSQLEMGK EPWVPDSVDM TSAMARGAYG RPGSDFCHGT EGKDLPSEHN VSVEGVAQDR
SPEATLCPQK TCPCDICGLR LKDILHLAEH QTTHPRQKPF VCEAYVKGSE FSANLPRKQV
QQNVHNPIRT EEGQASPVKT CRDHTSDQLS TCREGGKDFV ATAGFLQCEV TPSDGEPHEA
TEGVVDFHIA LRHNKCCESG DAFNNKSTLV QHQRIHSRER PYECSKCGIF FTYAADLTQH
QKVHNRGKPY ECCECGKFFS QHSSLVKHRR VHTGESPHVC GDCGKFFSRS SNLIQHKRVH
TGEKPYECSD CGKFFSQRSN LIHHKRVHTG RSAHECSECG KSFNCNSSLI KHWRVHTGER
PYKCNECGKF FSHIASLIQH QIVHTGERPH GCGECGKAFS RSSDLMKHQR VHTGERPYEC
NECGKLFSQS SSLNSHRRLH TGERPYQCSE CGKFFNQSSS LNNHRRLHTG ERPYECSECG
KTFRQRSNLR QHLKVHKPDR PYECSECGKA FNQRPTLIRH QKIHIRERSM ENVLLPCSQH
TPEISSENRP YQGAVNYKLK LVHPSTHPGE VP
