ZN793_HUMAN
ID ZN793_HUMAN Reviewed; 406 AA.
AC Q6ZN11; E9PGN4; Q7Z3Q9;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2013, sequence version 2.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Zinc finger protein 793;
GN Name=ZNF793;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Retina;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q6ZN11-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZN11-2; Sequence=VSP_026565;
CC Name=3;
CC IsoId=Q6ZN11-3; Sequence=VSP_026564;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAD97772.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK131417; BAD18564.1; -; mRNA.
DR EMBL; AC022148; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX537524; CAD97772.1; ALT_FRAME; mRNA.
DR CCDS; CCDS46062.1; -. [Q6ZN11-1]
DR RefSeq; NP_001013681.2; NM_001013659.2. [Q6ZN11-1]
DR RefSeq; XP_005258984.1; XM_005258927.3. [Q6ZN11-1]
DR RefSeq; XP_006723276.1; XM_006723213.3. [Q6ZN11-1]
DR AlphaFoldDB; Q6ZN11; -.
DR SMR; Q6ZN11; -.
DR BioGRID; 133738; 2.
DR IntAct; Q6ZN11; 2.
DR MINT; Q6ZN11; -.
DR STRING; 9606.ENSP00000396402; -.
DR iPTMnet; Q6ZN11; -.
DR PhosphoSitePlus; Q6ZN11; -.
DR BioMuta; ZNF793; -.
DR DMDM; 527504072; -.
DR MassIVE; Q6ZN11; -.
DR MaxQB; Q6ZN11; -.
DR PaxDb; Q6ZN11; -.
DR PeptideAtlas; Q6ZN11; -.
DR PRIDE; Q6ZN11; -.
DR ProteomicsDB; 67955; -. [Q6ZN11-2]
DR Antibodypedia; 29906; 39 antibodies from 12 providers.
DR DNASU; 390927; -.
DR Ensembl; ENST00000445217.5; ENSP00000396402.1; ENSG00000188227.14. [Q6ZN11-1]
DR Ensembl; ENST00000587143.5; ENSP00000468605.1; ENSG00000188227.14. [Q6ZN11-1]
DR Ensembl; ENST00000627814.3; ENSP00000487183.2; ENSG00000188227.14. [Q6ZN11-1]
DR GeneID; 390927; -.
DR KEGG; hsa:390927; -.
DR MANE-Select; ENST00000627814.3; ENSP00000487183.2; NM_001013659.3; NP_001013681.2.
DR UCSC; uc010xts.3; human. [Q6ZN11-1]
DR CTD; 390927; -.
DR DisGeNET; 390927; -.
DR GeneCards; ZNF793; -.
DR HGNC; HGNC:33115; ZNF793.
DR HPA; ENSG00000188227; Low tissue specificity.
DR neXtProt; NX_Q6ZN11; -.
DR OpenTargets; ENSG00000188227; -.
DR PharmGKB; PA162410548; -.
DR VEuPathDB; HostDB:ENSG00000188227; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163141; -.
DR HOGENOM; CLU_002678_0_9_1; -.
DR InParanoid; Q6ZN11; -.
DR OMA; LGCHCWE; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q6ZN11; -.
DR TreeFam; TF340838; -.
DR PathwayCommons; Q6ZN11; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q6ZN11; -.
DR BioGRID-ORCS; 390927; 11 hits in 1102 CRISPR screens.
DR ChiTaRS; ZNF793; human.
DR GenomeRNAi; 390927; -.
DR Pharos; Q6ZN11; Tdark.
DR PRO; PR:Q6ZN11; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q6ZN11; protein.
DR Bgee; ENSG00000188227; Expressed in cortical plate and 189 other tissues.
DR ExpressionAtlas; Q6ZN11; baseline and differential.
DR Genevisible; Q6ZN11; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 6.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 6.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..406
FT /note="Zinc finger protein 793"
FT /id="PRO_0000293699"
FT DOMAIN 8..79
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 227..249
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 255..277
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 283..305
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 311..333
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 339..361
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 367..389
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 1..94
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_026564"
FT VAR_SEQ 362..406
FT /note="TGEKPYGCNECGKAFYQKPNLSRHQKIHARKNAYRNENLIIVGNT -> FGE
FT SSLRSKSSNT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_026565"
FT VARIANT 68
FT /note="I -> M (in dbSNP:rs12977460)"
FT /id="VAR_033107"
FT VARIANT 133
FT /note="I -> V (in dbSNP:rs45593644)"
FT /id="VAR_061967"
FT CONFLICT 45
FT /note="V -> A (in Ref. 1; BAD18564)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 406 AA; 46927 MW; 3A037ABF2ACBF1C2 CRC64;
MIEYQIPVSF KDVVVGFTQE EWHRLSPAQR ALYRDVMLET YSNLVSVGYE GTKPDVILRL
EQEEAPWIGE AACPGCHCWE DIWRVNIQRK RRQDMLLRPG AAISKKTLPK EKSCEYNKFG
KISLLSTDLF SSIQSPSNWN PCGKNLNHNL DLIGFKRNCA KKQDECYAYG KLLQRINHGR
RPNGEKPRGC SHCEKAFTQN PALMYKPAVS DSLLYKRKRV PPTEKPHVCS ECGKAFCYKS
EFIRHQRSHT GEKPYGCTDC GKAFSHKSTL IKHQRIHTGV RPFECFFCGK AFTQKSHRTE
HQRTHTGERP FVCSECGKSF GEKSYLNVHR KMHTGERPYR CRECGKSFSQ KSCLNKHWRT
HTGEKPYGCN ECGKAFYQKP NLSRHQKIHA RKNAYRNENL IIVGNT
