ZN805_HUMAN
ID ZN805_HUMAN Reviewed; 627 AA.
AC Q5CZA5; B4DNM5;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 3.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Zinc finger protein 805;
GN Name=ZNF805;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 206-627.
RC TISSUE=Fetal kidney;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5CZA5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5CZA5-2; Sequence=VSP_040823;
CC -!- MISCELLANEOUS: [Isoform 1]: Gene prediction based on similarity to
CC orthologs.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAI56760.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK297977; BAG60287.1; -; mRNA.
DR EMBL; AC005261; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR936617; CAI56760.1; ALT_INIT; mRNA.
DR CCDS; CCDS46207.1; -. [Q5CZA5-1]
DR CCDS; CCDS46208.1; -. [Q5CZA5-2]
DR RefSeq; NP_001018857.2; NM_001023563.3. [Q5CZA5-1]
DR RefSeq; NP_001138550.1; NM_001145078.1. [Q5CZA5-2]
DR AlphaFoldDB; Q5CZA5; -.
DR SMR; Q5CZA5; -.
DR BioGRID; 133751; 5.
DR IntAct; Q5CZA5; 1.
DR STRING; 9606.ENSP00000412999; -.
DR iPTMnet; Q5CZA5; -.
DR PhosphoSitePlus; Q5CZA5; -.
DR BioMuta; ZNF805; -.
DR DMDM; 327478550; -.
DR EPD; Q5CZA5; -.
DR jPOST; Q5CZA5; -.
DR MassIVE; Q5CZA5; -.
DR MaxQB; Q5CZA5; -.
DR PaxDb; Q5CZA5; -.
DR PeptideAtlas; Q5CZA5; -.
DR PRIDE; Q5CZA5; -.
DR ProteomicsDB; 62731; -. [Q5CZA5-1]
DR ProteomicsDB; 62732; -. [Q5CZA5-2]
DR Antibodypedia; 67646; 66 antibodies from 12 providers.
DR DNASU; 390980; -.
DR Ensembl; ENST00000354309.4; ENSP00000365414.2; ENSG00000204524.7. [Q5CZA5-2]
DR Ensembl; ENST00000414468.3; ENSP00000412999.1; ENSG00000204524.7. [Q5CZA5-1]
DR GeneID; 390980; -.
DR KEGG; hsa:390980; -.
DR MANE-Select; ENST00000414468.3; ENSP00000412999.1; NM_001023563.4; NP_001018857.2.
DR UCSC; uc010ygt.3; human. [Q5CZA5-1]
DR CTD; 390980; -.
DR GeneCards; ZNF805; -.
DR HGNC; HGNC:23272; ZNF805.
DR HPA; ENSG00000204524; Low tissue specificity.
DR neXtProt; NX_Q5CZA5; -.
DR OpenTargets; ENSG00000204524; -.
DR PharmGKB; PA162410601; -.
DR VEuPathDB; HostDB:ENSG00000204524; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000159953; -.
DR HOGENOM; CLU_002678_5_0_1; -.
DR InParanoid; Q5CZA5; -.
DR OMA; HLEHEQE; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q5CZA5; -.
DR TreeFam; TF341817; -.
DR PathwayCommons; Q5CZA5; -.
DR SignaLink; Q5CZA5; -.
DR BioGRID-ORCS; 390980; 9 hits in 1099 CRISPR screens.
DR ChiTaRS; ZNF805; human.
DR GenomeRNAi; 390980; -.
DR Pharos; Q5CZA5; Tdark.
DR PRO; PR:Q5CZA5; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q5CZA5; protein.
DR Bgee; ENSG00000204524; Expressed in calcaneal tendon and 112 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 12.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..627
FT /note="Zinc finger protein 805"
FT /id="PRO_0000304624"
FT DOMAIN 13..84
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 203..225
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 231..253
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 259..281
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 287..309
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 315..337
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 343..365
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 371..393
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 399..421
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 427..449
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 455..477
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 483..505
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 511..533
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 539..561
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 71..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 113..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..128
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..155
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..133
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_040823"
FT VARIANT 68
FT /note="G -> E (in dbSNP:rs2014572)"
FT /id="VAR_057454"
SQ SEQUENCE 627 AA; 71143 MW; E87A25500E198AD7 CRC64;
MAMALTDPAQ VSVTFDDVAV TFTQEEWGQL DLAQRTLYQE VMLENCGLLV SLGCPVPRPE
LIYHLEHGQE PWTRKEDLSQ GTCPGDKGKP KSTEPTTCEL ALSEGISFWG QLTQGASGDS
QLGQPKDQDG FSEMQGERLR PGLDSQKEKL PGKMSPKHDG LGTADSVCSR IIQDRVSLGD
DVHDCDSHGS GKNPVIQEEE NIFKCNECEK VFNKKRLLAR HERIHSGVKP YECTECGKTF
SKSTYLLQHH MVHTGEKPYK CMECGKAFNR KSHLTQHQRI HSGEKPYKCS ECGKAFTHRS
TFVLHNRSHT GEKPFVCKEC GKAFRDRPGF IRHYIIHSGE NPYECFECGK VFKHRSYLMW
HQQTHTGEKP YECSECGKAF CESAALIHHY VIHTGEKPFE CLECGKAFNH RSYLKRHQRI
HTGEKPYVCS ECGKAFTHCS TFILHKRAHT GEKPFECKEC GKAFSNRADL IRHFSIHTGE
KPYECMECGK AFNRRSGLTR HQRIHSGEKP YECIECGKTF CWSTNLIRHS IIHTGEKPYE
CSECGKAFSR SSSLTQHQRM HTGRNPISVT DVGRPFTSGQ TSVNIQELLL GKNFLNVTTE
ENLLQEEASY MASDRTYQRE TPQVSSL
