ZN808_HUMAN
ID ZN808_HUMAN Reviewed; 903 AA.
AC Q8N4W9; Q68CN7;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 171.
DE RecName: Full=Zinc finger protein 808;
GN Name=ZNF808;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Retina;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-173, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N4W9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N4W9-2; Sequence=VSP_034946;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH33230.1; Type=Miscellaneous discrepancy; Note=In 3'-UTR.; Evidence={ECO:0000305};
CC Sequence=AAI30352.1; Type=Miscellaneous discrepancy; Note=In 3'-UTR.; Evidence={ECO:0000305};
CC Sequence=AAI30354.1; Type=Miscellaneous discrepancy; Note=In 3'-UTR.; Evidence={ECO:0000305};
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DR EMBL; CR749856; CAH18701.1; -; mRNA.
DR EMBL; AC022150; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471135; EAW72084.1; -; Genomic_DNA.
DR EMBL; BC033230; AAH33230.1; ALT_SEQ; mRNA.
DR EMBL; BC130351; AAI30352.1; ALT_SEQ; mRNA.
DR EMBL; BC130353; AAI30354.1; ALT_SEQ; mRNA.
DR CCDS; CCDS46167.1; -. [Q8N4W9-1]
DR CCDS; CCDS86799.1; -. [Q8N4W9-2]
DR RefSeq; NP_001034975.2; NM_001039886.3. [Q8N4W9-1]
DR RefSeq; NP_001308353.1; NM_001321424.1. [Q8N4W9-1]
DR RefSeq; NP_001308354.1; NM_001321425.1. [Q8N4W9-1]
DR RefSeq; XP_005258966.1; XM_005258909.3. [Q8N4W9-2]
DR AlphaFoldDB; Q8N4W9; -.
DR SMR; Q8N4W9; -.
DR BioGRID; 132741; 6.
DR IntAct; Q8N4W9; 1.
DR STRING; 9606.ENSP00000352846; -.
DR iPTMnet; Q8N4W9; -.
DR PhosphoSitePlus; Q8N4W9; -.
DR BioMuta; ZNF808; -.
DR DMDM; 212288109; -.
DR EPD; Q8N4W9; -.
DR jPOST; Q8N4W9; -.
DR MassIVE; Q8N4W9; -.
DR MaxQB; Q8N4W9; -.
DR PaxDb; Q8N4W9; -.
DR PeptideAtlas; Q8N4W9; -.
DR PRIDE; Q8N4W9; -.
DR ProteomicsDB; 71984; -. [Q8N4W9-1]
DR ProteomicsDB; 71985; -. [Q8N4W9-2]
DR DNASU; 388558; -.
DR Ensembl; ENST00000359798.9; ENSP00000352846.4; ENSG00000198482.14. [Q8N4W9-1]
DR Ensembl; ENST00000487863.5; ENSP00000420522.1; ENSG00000198482.14. [Q8N4W9-2]
DR GeneID; 388558; -.
DR KEGG; hsa:388558; -.
DR MANE-Select; ENST00000359798.9; ENSP00000352846.4; NM_001039886.4; NP_001034975.2.
DR UCSC; uc002pzq.3; human. [Q8N4W9-1]
DR CTD; 388558; -.
DR GeneCards; ZNF808; -.
DR HGNC; HGNC:33230; ZNF808.
DR HPA; ENSG00000198482; Low tissue specificity.
DR neXtProt; NX_Q8N4W9; -.
DR PharmGKB; PA162410633; -.
DR VEuPathDB; HostDB:ENSG00000198482; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT01050000244829; -.
DR HOGENOM; CLU_002678_17_0_1; -.
DR InParanoid; Q8N4W9; -.
DR OMA; MSYLVCH; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8N4W9; -.
DR TreeFam; TF343410; -.
DR PathwayCommons; Q8N4W9; -.
DR SignaLink; Q8N4W9; -.
DR BioGRID-ORCS; 388558; 13 hits in 1069 CRISPR screens.
DR ChiTaRS; ZNF808; human.
DR GenomeRNAi; 388558; -.
DR Pharos; Q8N4W9; Tdark.
DR PRO; PR:Q8N4W9; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8N4W9; protein.
DR Bgee; ENSG00000198482; Expressed in colonic epithelium and 105 other tissues.
DR ExpressionAtlas; Q8N4W9; baseline and differential.
DR Genevisible; Q8N4W9; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 18.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 23.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 14.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 23.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 24.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Isopeptide bond; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Ubl conjugation; Zinc;
KW Zinc-finger.
FT CHAIN 1..903
FT /note="Zinc finger protein 808"
FT /id="PRO_0000304991"
FT DOMAIN 24..98
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 231..253
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 259..281
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 287..309
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 315..337
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 343..365
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 371..393
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 399..421
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 427..449
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 455..477
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 483..505
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 511..533
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 539..561
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 567..589
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 595..617
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 623..645
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 651..673
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 679..701
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 707..729
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 735..757
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 763..785
FT /note="C2H2-type 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 791..813
FT /note="C2H2-type 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 819..841
FT /note="C2H2-type 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 847..869
FT /note="C2H2-type 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 875..897
FT /note="C2H2-type 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 121..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..151
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 173
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 1..69
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_034946"
FT VARIANT 134
FT /note="K -> N (in dbSNP:rs329964)"
FT /id="VAR_045823"
FT VARIANT 262
FT /note="D -> N (in dbSNP:rs329965)"
FT /id="VAR_045824"
SQ SEQUENCE 903 AA; 104825 MW; BA38357A1D5A5CBA CRC64;
MLREEAAQKR KGKESGMALP QGRLTFRDVA IEFSLAEWKF LNPAQRALYR EVMLENYRNL
EAVDISSKHM MKEVLSTGQG NREVIHTGTL QRHQSYHIGD FCFQEIEKEI HNIEFQCQED
ERNGHEAPTT KIKKLTGSTD QHDHRHAGNK PIKDQLGSSF YSHLPELHIF QIKGEIANQL
EKSTSDASSV STSQRISCRP QIHISNNYGN NPLNSSLLPQ KQEVHMREKS FPCNESGKAF
NCSSLLRKHQ IPHLGDKQYK CDVCGKLFNH KQYLACHRRC HTGEKPYKCK ECGKSFSYKS
SLTCHHRLHT GVKPYKCNEC GKVFRQNSAL VIHKAIHTGE KPYKCNECGK AFNQQSHLSR
HQRLHTGVKP YKCKICEKAF ACHSYLANHT RIHSGEKTYK CNECGKAFNH QSSLARHHIL
HTGEKPYKCE ECDKVFSQKS TLERHKRIHT GEKPYKCKVC DTAFTCNSQL ARHRRIHTGE
KTYKCNECRK TFSRRSSLLC HRRLHSGEKP YKCNQCGNTF RHRASLVYHR RLHTLEKSYK
CTVCNKVFMR NSVLAVHTRI HTAKKPYKCN ECGKAFNQQS HLSRHRRLHT GEKPYKCEAC
DKVFGQKSAL ESHKRIHTGE KPYRCQVCDT AFTWNSQLAR HTRIHTGEKT YKCNECGKTF
SYKSSLVWHR RLHGGEKSYK CKVCDKAFVC RSYVAKHTRI HSGMKPYKCN ECSKTFSNRS
SLVCHRRIHS GEKPYKCSEC SKTFSQKATL LCHRRLHSGE KPYKCNDCGN TFRHWSSLVY
HRRLHTGEKS YKCTVCDKAF VRNSYLARHI RIHTAEKPYK CNECGKAFNE QSHLSRHHRI
HTGEKPYKCE ACDKVFSRKS HLKRHRIIHT GEKPYKCNEC GKAFSDRSTL IHHQAIHGIG
KFD
