ZN813_HUMAN
ID ZN813_HUMAN Reviewed; 617 AA.
AC Q6ZN06;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Zinc finger protein 813;
GN Name=ZNF813;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 164-617.
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD18569.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AC022137; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK131422; BAD18569.1; ALT_INIT; mRNA.
DR CCDS; CCDS46172.1; -.
DR RefSeq; NP_001004301.2; NM_001004301.3.
DR AlphaFoldDB; Q6ZN06; -.
DR SMR; Q6ZN06; -.
DR BioGRID; 125948; 16.
DR IntAct; Q6ZN06; 3.
DR STRING; 9606.ENSP00000379684; -.
DR iPTMnet; Q6ZN06; -.
DR PhosphoSitePlus; Q6ZN06; -.
DR BioMuta; ZNF813; -.
DR DMDM; 152112420; -.
DR EPD; Q6ZN06; -.
DR jPOST; Q6ZN06; -.
DR MassIVE; Q6ZN06; -.
DR MaxQB; Q6ZN06; -.
DR PaxDb; Q6ZN06; -.
DR PeptideAtlas; Q6ZN06; -.
DR PRIDE; Q6ZN06; -.
DR ProteomicsDB; 67952; -.
DR Antibodypedia; 67264; 63 antibodies from 14 providers.
DR DNASU; 126017; -.
DR Ensembl; ENST00000396403.9; ENSP00000379684.4; ENSG00000198346.11.
DR GeneID; 126017; -.
DR KEGG; hsa:126017; -.
DR MANE-Select; ENST00000396403.9; ENSP00000379684.4; NM_001004301.4; NP_001004301.2.
DR UCSC; uc002qbu.3; human.
DR CTD; 126017; -.
DR DisGeNET; 126017; -.
DR GeneCards; ZNF813; -.
DR HGNC; HGNC:33257; ZNF813.
DR HPA; ENSG00000198346; Low tissue specificity.
DR neXtProt; NX_Q6ZN06; -.
DR OpenTargets; ENSG00000198346; -.
DR PharmGKB; PA162410661; -.
DR VEuPathDB; HostDB:ENSG00000198346; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000154397; -.
DR HOGENOM; CLU_002678_44_4_1; -.
DR InParanoid; Q6ZN06; -.
DR OMA; HKAIHIG; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q6ZN06; -.
DR TreeFam; TF341892; -.
DR PathwayCommons; Q6ZN06; -.
DR SignaLink; Q6ZN06; -.
DR BioGRID-ORCS; 126017; 18 hits in 1027 CRISPR screens.
DR ChiTaRS; ZNF813; human.
DR GenomeRNAi; 126017; -.
DR Pharos; Q6ZN06; Tdark.
DR PRO; PR:Q6ZN06; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q6ZN06; protein.
DR Bgee; ENSG00000198346; Expressed in colonic epithelium and 104 other tissues.
DR ExpressionAtlas; Q6ZN06; baseline and differential.
DR Genevisible; Q6ZN06; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 10.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..617
FT /note="Zinc finger protein 813"
FT /id="PRO_0000294363"
FT DOMAIN 8..81
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 215..237
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 243..265
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 271..293
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 299..321
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 327..349
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 355..377
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 383..405
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 411..433
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 439..461
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 467..489
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 495..517
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 523..545
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 551..573
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 579..601
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 62
FT /note="A -> T (in dbSNP:rs2617667)"
FT /id="VAR_052905"
FT VARIANT 93
FT /note="D -> V (in dbSNP:rs12609217)"
FT /id="VAR_052906"
FT VARIANT 168
FT /note="I -> F (in dbSNP:rs12460628)"
FT /id="VAR_052907"
FT VARIANT 192
FT /note="Y -> C (in dbSNP:rs3859494)"
FT /id="VAR_052908"
FT VARIANT 231
FT /note="R -> K (in dbSNP:rs10421308)"
FT /id="VAR_033167"
FT VARIANT 439
FT /note="Y -> F (in dbSNP:rs10422163)"
FT /id="VAR_033168"
SQ SEQUENCE 617 AA; 71721 MW; B194D8BE2FA449FE CRC64;
MALPQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLDIS SKCMMKEFSS
TAQGNREVIH TGTLQRHESH HTGDFRFQEI DKDIHNLEFQ WQEDERNSHE APMTEIKKLT
GSADRYDQRH AGNKPIKDQL GSSFHSHLPE LHMFQTQGKI GNQVEKSIND ASSISTSQRI
SCRPKTHISN NYGNNFRNSS LLTQKQEVHM REKSFQCNES GKAFNYSSLL RKHQIIHLGE
KQYKCDVCGK VFNRKRNLVC HRRCHTGEKP YRCNECGKTF SQTYSLTCHR RLHTGEKPYK
CEECDKAFSF KSNLKRHRRI HAGEKPYKCN ECGKTFSQTS SLTCHRRLHT GEKPFKCNEC
GKTFSRKSSL TCHHRLHTGE KPYKCNECGK TFSQELTLKC HRRLHTGEKP YKCNECGKVF
NKKANLARHH RLHSGEKPYK CTECVKTFSR NSALVIHKAI HIGEKRYKCN ECGKTFSRIS
ALVIHTAIHT GEKPYKCNEC GKGFNRKTHL ACHHRLHTGE KPYKCNECGK VFNRKTHLAH
HHRLHTGDKP YKCNECGKVF NQKAHLARHH RLHTGEKPYK CNECGKVFNQ KANLARHHRL
HTGEKPYKFN ECGKAFN
