ZN814_HUMAN
ID ZN814_HUMAN Reviewed; 855 AA.
AC B7Z6K7; A6NF35;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 15-JUN-2010, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Zinc finger protein 814;
GN Name=ZNF814;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Prostate;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-335 AND LYS-391, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25218447; DOI=10.1038/nsmb.2890;
RA Hendriks I.A., D'Souza R.C., Yang B., Verlaan-de Vries M., Mann M.,
RA Vertegaal A.C.;
RT "Uncovering global SUMOylation signaling networks in a site-specific
RT manner.";
RL Nat. Struct. Mol. Biol. 21:927-936(2014).
RN [5]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-335 AND LYS-391, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
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DR EMBL; AK300483; BAH13293.1; -; mRNA.
DR EMBL; AC010326; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471135; EAW72539.1; -; Genomic_DNA.
DR CCDS; CCDS46212.1; -.
DR RefSeq; NP_001138461.1; NM_001144989.1.
DR AlphaFoldDB; B7Z6K7; -.
DR SMR; B7Z6K7; -.
DR BioGRID; 610440; 1.
DR STRING; 9606.ENSP00000410545; -.
DR iPTMnet; B7Z6K7; -.
DR PhosphoSitePlus; B7Z6K7; -.
DR BioMuta; ZNF814; -.
DR EPD; B7Z6K7; -.
DR jPOST; B7Z6K7; -.
DR MassIVE; B7Z6K7; -.
DR PaxDb; B7Z6K7; -.
DR PeptideAtlas; B7Z6K7; -.
DR PRIDE; B7Z6K7; -.
DR ProteomicsDB; 6783; -.
DR TopDownProteomics; B7Z6K7; -.
DR Antibodypedia; 52693; 2 antibodies from 2 providers.
DR DNASU; 730051; -.
DR Ensembl; ENST00000435989.7; ENSP00000410545.1; ENSG00000204514.11.
DR GeneID; 730051; -.
DR KEGG; hsa:730051; -.
DR MANE-Select; ENST00000435989.7; ENSP00000410545.1; NM_001144989.2; NP_001138461.1.
DR UCSC; uc002qqo.3; human.
DR CTD; 730051; -.
DR GeneCards; ZNF814; -.
DR HGNC; HGNC:33258; ZNF814.
DR HPA; ENSG00000204514; Low tissue specificity.
DR neXtProt; NX_B7Z6K7; -.
DR OpenTargets; ENSG00000204514; -.
DR PharmGKB; PA164727759; -.
DR VEuPathDB; HostDB:ENSG00000204514; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000165204; -.
DR HOGENOM; CLU_002678_17_1_1; -.
DR InParanoid; B7Z6K7; -.
DR OMA; HPRERSY; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; B7Z6K7; -.
DR TreeFam; TF343410; -.
DR PathwayCommons; B7Z6K7; -.
DR BioGRID-ORCS; 730051; 17 hits in 1106 CRISPR screens.
DR ChiTaRS; ZNF814; human.
DR GenomeRNAi; 730051; -.
DR Pharos; B7Z6K7; Tdark.
DR PRO; PR:B7Z6K7; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; B7Z6K7; protein.
DR Bgee; ENSG00000204514; Expressed in colonic epithelium and 175 other tissues.
DR ExpressionAtlas; B7Z6K7; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 22.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 23.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 12.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 23.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 23.
PE 1: Evidence at protein level;
KW Isopeptide bond; Metal-binding; Reference proteome; Repeat;
KW Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1..855
FT /note="Zinc finger protein 814"
FT /id="PRO_0000394964"
FT DOMAIN 15..91
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 120..142
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 242..264
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 269..291
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 296..318
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 324..346
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 352..374
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 380..402
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 408..430
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 436..458
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 464..486
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 492..514
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 520..542
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 548..570
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 576..598
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 604..626
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 632..654
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 660..682
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 688..710
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 716..738
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 744..766
FT /note="C2H2-type 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 772..794
FT /note="C2H2-type 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 800..822
FT /note="C2H2-type 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 828..850
FT /note="C2H2-type 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CROSSLNK 335
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:25218447,
FT ECO:0007744|PubMed:28112733"
FT CROSSLNK 391
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:25218447,
FT ECO:0007744|PubMed:28112733"
FT CONFLICT 158
FT /note="A -> V (in Ref. 1; BAH13293)"
FT /evidence="ECO:0000305"
FT CONFLICT 230
FT /note="S -> C (in Ref. 1; BAH13293)"
FT /evidence="ECO:0000305"
FT CONFLICT 296
FT /note="H -> HY (in Ref. 1; BAH13293 and 3; EAW72539)"
FT /evidence="ECO:0000305"
FT CONFLICT 591
FT /note="L -> H (in Ref. 1; BAH13293)"
FT /evidence="ECO:0000305"
FT CONFLICT 769
FT /note="E -> K (in Ref. 1; BAH13293)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 855 AA; 97337 MW; 7C497F30FCAACB17 CRC64;
MAAAATLRLS AQGTVTFEDV AVNFTWEEWN LLSEAQRCLY RDVTLENLAL ISSLGCWCGV
EDEAAPSKQS IYIQRETQVR TPMAGVSPKK AHPCEMCGPI LGDILHVADH QGTHHKQKLH
RCEAWGNKLY DSGNFHQHQN EHIGEKPYRG SVEEALFAKR CKLHVSGESS VFSESGKDFL
PRSGLLQQEA SHTGEKSNSK TECVSPIQCG GAHYSCGESM KHFSTKHILS QHQRLLTREE
CYVCCECGKS FSKYASLSNH QRVHTEKKHE CGECGKSFSK YVSFSNHQRV HTEKKHECGE
CGKSFSKYVS FSNHQRVHTG KRPYECGECG KSFSKYASFS NHQRVHTEKK HYECGECGKS
FSKYVSFSNH QRVHTGKRPY ECGECGKSFS KYASFSNHQR VHTDKKHYEC GECGKSFSQK
SSLIQHQRFH TGEKPYGCEE CGKSFSSEGH LRSHQRVHAG ERPFKCGECV KSFSHKRSLV
HHQRVHSGER PYQCGECGKS FSQKGNLVLH QRVHTGARPY ECGECGKSFS SKGHLRNHQQ
IHTGDRLYEC GECGKSFSHK GTLILHQRVH PRERSYGCGE CGKSFSSIGH LRSHQRVHTG
ERPYECGECG KSFSHKRSLV HHQRMHTGER PYKCGDCGKS FNEKGHLRNH QRVHTTERPF
KCGECGKCFS HKGNLILHQH GHTGERPYVC RECGKLFKKK SHLLVHQRIH NGEKPYACEA
CQKFFRNKYQ LIAHQRVHTG ERPYECNDCG KSFTHSSTFC VHKRIHTGEK PYECSECGKS
FAESSSFTKH KRVHTGEKPY ECSECGKSFA ESSSLTKHKR VHTGEKPYKC EKCGKLFNKK
SHLLVHQSSH WRKAI
